Conditions | Yield |
---|---|
In methanol (N2); dropwise addn. of the Sn-compound in MeOH to a suspension of ascorbate in MeOH with stirring at 0°C; after allowing to warm up to room temp. the mixt. is heated under reflux for 3 h; volatiles are removed in vac. and the solid is successively washed with CH2Cl2 and THF and water, recrystn. from MeOH; elem. anal.; | 85% |
Conditions | Yield |
---|---|
In methanol (N2;) dropwise addn. of Sn compound in MeOH to a suspension of ascorbate in MeOH with stirring at 0°C; after allowing to warm up to room temp. the mixt. is heated under reflux for 3.5 h; volatiles are removed in vac. and the solid is successively washed with CH2Cl2 and THF, recrystn. from MeOH; elem. anal.; | 73% |
Conditions | Yield |
---|---|
In methanol byproducts: NaCl; (N2); soln. of Sn compd. (1 equiv.) in methanol was added dropwise with stirring to suspn. of ascorbate (2 equiv.) in methanol at 0°C; soln. was warmed to room temp.; refluxed for 3 h; filtered; concd. (vac.); washed (CH2Cl2); recrystd. (methanol); elem. anal.; | 50% |
Conditions | Yield |
---|---|
In methanol byproducts: NaCl; (N2); soln. of Sn compd. (1 equiv.) in methanol was added dropwise with stirring to suspn. of ascorbate (1 equiv.) in methanol; soln. was stirred at room temp. for 10 min; refluxed for 6 h; filtered; volatiles removed (vac.); washed (CH2Cl2); dried (vac.); recrystd. (methanol); elem. anal.; | 47% |
Conditions | Yield |
---|---|
In water (N2); dropwise addn. of a soln. of ascorbate in water to a soln. of the Ti-compd. in water with stirring at 10°C, stirring of the mixt. for 2 h; allowing to warm slowly up to room temp.;; ppt. is collected by filtn., washed with cooled water and redissolved in THF, pptn. by addn. of hexane; elem. anal.; | 45% |
Conditions | Yield |
---|---|
In methanol byproducts: NaCl; (N2); soln. of Sn compd. (1 equiv.) in methanol was added dropwise with stirring to suspn. of ascorbate (1 equiv.) in methanol; soln. was stirred at room temp. for 10 min; refluxed for 6 h; filtered; volatiles removed (vac.); washed (CH2Cl2); dried (vac.); recrystd. (methanol); elem. anal.; | 23% |
Conditions | Yield |
---|---|
In methanol byproducts: NaCl; (N2); soln. of Sn compd. (1 equiv.) in methanol was added dropwise with stirring to suspn. of ascorbate (1 equiv.) in methanol; soln. was stirred at room temp. for 10 min; refluxed for 6 h; filtered; volatiles removed (vac.); washed (CH2Cl2); dried (vac.); recrystd. (methanol); elem. anal.; | 20% |
Conditions | Yield |
---|---|
In methanol byproducts: NaCl; (N2); soln. of Sn compd. (1 equiv.) in methanol was added dropwise with stirring to suspn. of ascorbate (2 equiv.) in methanol at 0°C; soln. was warmed to room temp.; refluxed for 3 h; filtered; concd. (vac.); washed (CH2Cl2); recrystd. (methanol); elem. anal.; | 20% |
Conditions | Yield |
---|---|
In methanol byproducts: NaCl; (N2); soln. of Sn compd. (1 equiv.) in methanol was added dropwise with stirring to suspn. of ascorbate (1 equiv.) in methanol; soln. was stirred at room temp. for 10 min; refluxed for 6 h; filtered; volatiles removed (vac.); washed (CH2Cl2); dried (vac.); recrystd. (methanol); elem. anal.; | 20% |
sodium ascorbate
2-O-α-D-glucopyranosyl L-ascorbate
Conditions | Yield |
---|---|
rat intestinal (or rice seed) α-glucosidase, maltose, thiourea, 0.1 M acetate buffer, 3 h, 50 deg C, in the dark; | 14% |
sodium ascorbate
alpha cyclodextrin
2-O-α-D-glucopyranosyl L-ascorbate
Conditions | Yield |
---|---|
Stage #1: sodium ascorbate; alpha cyclodextrin With cyclodextrin glucanotransferase from Thermoanaerobacter sp. In aq. acetate buffer at 40℃; for 24h; pH=4.0; Enzymatic reaction; Stage #2: With amyloglucosidase from Aspergillus niger In aq. acetate buffer at 60℃; for 2h; Enzymatic reaction; regioselective reaction; | 0.27% |
Conditions | Yield |
---|---|
Stage #1: sodium ascorbate; β‐cyclodextrin With cyclodextrin glucanotransferase from Thermoanaerobacter sp. In aq. acetate buffer at 40℃; for 24h; pH=4.0; Enzymatic reaction; Stage #2: With amyloglucosidase from Aspergillus niger In aq. acetate buffer at 60℃; for 2h; Enzymatic reaction; regioselective reaction; | 0.24% |
sodium ascorbate
cyclomaltooctaose
2-O-α-D-glucopyranosyl L-ascorbate
Conditions | Yield |
---|---|
Stage #1: sodium ascorbate; cyclomaltooctaose With cyclodextrin glucanotransferase from Thermoanaerobacter sp. In aq. acetate buffer at 40℃; for 24h; pH=4.0; Enzymatic reaction; Stage #2: With amyloglucosidase from Aspergillus niger In aq. acetate buffer at 60℃; for 2h; Enzymatic reaction; regioselective reaction; | 0.21% |
Maltose
sodium ascorbate
2-O-α-D-glucopyranosyl L-ascorbate
Conditions | Yield |
---|---|
With acetate buffer; rice seed α-glucosidase; thiourea at 50℃; for 5h; |
water
sodium ascorbate
A
oxalic acid
B
L-threonic acid-4-lactone
Conditions | Yield |
---|---|
Behandeln des Natrium-Salzes oder anderer Alkalisalze; |
Conditions | Yield |
---|---|
In not given pptg. with methanol; | |
In not given pptg. with methanol; |
Conditions | Yield |
---|---|
With tris(2,2'-bipyridyl)ruthenium dichloride; C18H23N3NiS3(2+)*2ClO4(1-) In N,N-dimethyl acetamide; water pH=4; Catalytic behavior; Irradiation; |
Reported in EPA TSCA Inventory.
1. Introduction of Sodium ascorbate
Sodium ascorbate is a more bioavailable[citation needed] form of vitamin C that is an alternative to taking ascorbic acid as a supplement. The IUPAC Name of it is Sodium (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2H-furan-3-olate
2. Properties of Sodium ascorbate
H-Bond Donor: 3
H-Bond Acceptor: 6
Rotatable Bond Count: 2
Tautomer Count: 2
Exact Mass: 198.014033
MonoIsotopic Mass 198.014033
Topological Polar Surface Area: 110
Heavy Atom Count: 13
Complexity: 237
Solubility: H2O: 50 mg/mL
Water Solubility: 620 g/L (20 °C)
Melting Point: 220 °C (dec.)(lit.)
alpha: 104 °(C=1, H2O 25 °C)
Refractive index: 105.5 °(C=10, H2O)
Flash Point: 238.2 °C
Enthalpy of Vaporization: 95.78 kJ/mol
Boiling Point: 552.7 °C at 760 mmHg
Vapour Pressure of Sodium ascorbate: 1.62E-14 mmHg at 25 °C
3. Structure Descriptors of Sodium ascorbate
Canonical SMILES: C(C(C1C(=C(C(=O)O1)O)[O-])O)O.[Na+]
InChI: InChI=1/C6H8O6.Na/c7-1-2(8)5-3(9)4(10)6(11)12-5;/h2,5,7-10H,1H2;/q;+1/p-1/t2-,5?;/m0./s1
EINECS: 205-126-1
Classification Code: Mutation data; Vitamin
Product Categories: Food and Feed Additive; Antioxidant; Biochemistry; Sugar Acids; Sugars; Vitamins; Vitamins and derivatives
Stability: Stable. Incompatible with strong oxidizing agents.
Storage temperature: Store at RT.
4. Toxicity of Sodium ascorbate
1. | sce-hmn:lym 100 µmol/L | MUREAV Mutation Research. 60 (1979),321. | ||
2. | oms-ham:ovr 1 mmol/L | CNREA8 Cancer Research. 39 (1979),4145. | ||
3. | cyt-ham:ovr 20 mmol/L | CNREA8 Cancer Research. 39 (1979),4145. | ||
4. | sce-ham:ovr 100 µmol/L | MUREAV Mutation Research. 60 (1979),321. |
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