tert-BUTYL GLYCIDYL ETHER supplier

Name
TERT-BUTYL GLYCIDYL ETHER
EINECS
CAS No. 7665-72-7
Article Data10
CAS DataBase
Density 0.944g/cm³
Solubility 90.3g/L at 20℃
Melting Point -70oC
Formula C7H14 O2
Boiling Point 152°Cat760mmHg
Molecular Weight 130.187
Flash Point 43.3°C
Transport Information
Appearance
Safety Suspected carcinogen. Moderately toxic by ingestion. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating vapors.
Risk Codes 10-19-22-36-43
Molecular Structure
Hazard Symbols Xn
Synonyms Oxirane,[(1,1-dimethylethoxy)methyl]- (9CI); Propane, 1-tert-butoxy-2,3-epoxy-(6CI,7CI); (tert-Butoxymethyl)oxirane; (?à)-tert-Butylglycidyl ether; 1,1-Dimethylethyl glycidylether; 1-tert-Butoxy-2,3-epoxypropane; 2,3-Epoxypropyl-tert-butyl ether;2-(tert-Butoxymethyl)oxirane; 3-tert-Butoxy-1,2-epoxypropane; Glycidyltert-butyl ether; tert-Butyl 2,3-epoxypropyl ether; tert-Butyl glycidyl ether
PSA 21.76000
LogP 1.20030

Synthetic route

: 22576-65-4
1-chloro-3-tert-butoxy-2-propanol

: 7665-72-7
t-butyl glycidyl ether

Conditions

Conditions	Yield
With sodium hydroxide at 5℃; for 1h;	70%
With sodium hydroxide In hexane at 60℃; for 2h;	61.5%

: 106-89-8
epichlorohydrin

: 75-65-0
tert-butyl alcohol

: 7665-72-7
t-butyl glycidyl ether

Conditions

Conditions	Yield
With diethyl ether; boron trifluoride Behandeln mit wss. Natronlauge;
With tin(IV) chloride at 90 - 100℃; for 0.333333h;

: 1471-04-1
allyl tert-butyl ether

: 7665-72-7
t-butyl glycidyl ether

Conditions

Conditions	Yield
With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 45℃; for 48h;

: 3132-64-7
1,2-Epoxy-3-bromopropane

: 75-65-0
tert-butyl alcohol

: 7665-72-7
t-butyl glycidyl ether

Conditions

Conditions	Yield
With boron trifluoride In diethyl ether at 50 - 55℃;

: 7665-72-7
t-butyl glycidyl ether

: 62-53-3
aniline

: 1-tert-butoxy-3-phenylamino-propan-2-ol

Conditions

Conditions	Yield
With zirconium(IV) chloride at 20℃; for 0.25h;	100%
With lithium bromide at 20℃; for 5h;	100%
silica gel at 20℃; for 3h;	100%

: 7665-72-7
t-butyl glycidyl ether

: 1030377-21-9
(S)-2-(hydroxymethyl)piperazine-1-carboxylic acid tert-butyl ester

: (2S)-tert-butyl 4-(3-(tert-butoxy)-2-hydroxypropyl)-2-(hydroxymethyl)piperazine-1-carboxylate

Conditions

Conditions	Yield
In ethanol at 120℃; for 0.5h; Microwave irradiation;	100%

: 7665-72-7
t-butyl glycidyl ether

: 124-38-9
carbon dioxide

: 84137-72-4
4-[(1,1-dimethylethoxy)methyl]-1,3-dioxolan-2-one

Conditions

Conditions	Yield
With tri-n-butyl(2-hydroxyethyl)ammonium iodide In neat (no solvent) at 45℃; under 7500.75 Torr; for 18h; Temperature; Pressure; Autoclave;	99%
With 18-crown-6 ether; calcium iodide In neat (no solvent) at 23℃; under 760.051 Torr; for 24h; Catalytic behavior; Reagent/catalyst; Temperature; Pressure;	99%
With calcium iodide In neat (no solvent) at 25℃; under 7500.75 Torr; for 24h;	99%

: 7665-72-7
t-butyl glycidyl ether

: 1-tert-butoxy-3-iodo-propan-2-ol

Conditions

Conditions	Yield
With lithium iodide; 1-hexyl-3-methylimidazolium perchlorate at 25℃; for 1h;	98%
With iodine; 5,15,10,20-tetraphenylporphyrin In dichloromethane at 20℃; for 5.8h; regioselective reaction;	77%

: 7665-72-7
t-butyl glycidyl ether

: 67-64-1
acetone

: 122977-52-0
4-(tert-butoxymethyl)-2,2-dimethyl-1,3-dioxolane

Conditions

Conditions	Yield
With Cr-pillared montmorillonite for 4h; Reflux;	97%
With FeOx-pillared bentonite at 60℃; for 2h;	63%
With FeOx-pillared bentonite at 60℃; for 2h;	63 %Chromat.

: 7665-72-7
t-butyl glycidyl ether

: 540-63-6
ethane-1,2-dithiol

: 1-(tert-butoxy)-3-[(2-[3-(tert-butoxy)-2-hydroxypropyl]sulfanylethyl)sulfanyl]-2-propanol

Conditions

Conditions	Yield
With potassium carbonate for 3h; Heating;	96%
N-benzyl-trimethylammonium hydroxide
With potassium carbonate In water Reflux;

: 7665-72-7
t-butyl glycidyl ether

: 1826-67-1
vinyl magnesium bromide

: 1-(tert-butoxy)pent-4-en-2-ol

Conditions

Conditions	Yield
With hydrogenchloride; methanol; copper(I) bromide dimethylsulfide complex; triphenylphosphine In tetrahydrofuran; water at 0℃; for 8h; Inert atmosphere; Flow reactor; regioselective reaction;	96%

: 7665-72-7
t-butyl glycidyl ether

: 3282-30-2
pivaloyl chloride

: C12H23ClO3

Conditions

Conditions	Yield
With iron(III) chloride In neat (no solvent) at 20℃; for 0.0833333h; regiospecific reaction;	95%

: 7665-72-7
t-butyl glycidyl ether

: 95-51-2
2-Chloroaniline

: 1-tert-butoxy-3-(2-chloro-phenylamino)-propan-2-ol

Conditions

Conditions	Yield
With aluminium(III) triflate In toluene at 100℃; for 5h;	94%
With BiCl6(3-)2C4H10N2ClH3H(1+)H2O at 20℃; for 0.15h; Neat (no solvent); regioselective reaction;	86%

: 7665-72-7
t-butyl glycidyl ether

: 1-Bromo-3-tert-butoxy-propan-2-ol

Conditions

Conditions	Yield
With lithium bromide; 1-hexyl-3-methylimidazolium perchlorate at 25℃; for 1h;	92%
With bromine; 5,15,10,20-tetraphenylporphyrin In dichloromethane at 20℃; for 3.5h; regioselective reaction;	78%

: 7665-72-7
t-butyl glycidyl ether

: 75-15-0
carbon disulfide

: 5-tert-butoxymethyl-1,3-oxathiolane-2-thione

Conditions

Conditions	Yield
With lithium tert-butoxide In neat (no solvent) at 20℃; for 5h; stereoselective reaction;	92%
With lithium tert-butoxide In neat (no solvent) at 25℃; for 5h; Sealed tube; regioselective reaction;	92%

: 7665-72-7
t-butyl glycidyl ether

: 107806-76-8
1,2-epithio-3-tert-butoxypropane

Conditions

Conditions	Yield
With potassium thioacyanate; but-2-ene-1,4-diylbis(triphenylphosphinium) dichloride In water at 20℃; for 3h; Green chemistry;	91%
With sulfuric acid; thiourea In water for 2h; Ambient temperature;	75%
With silica gel; 1-methyl-pyrrolidine-2-thione In dichloromethane at 20℃; for 3.5h;	62.8%

: 7665-72-7
t-butyl glycidyl ether

: 100-61-8
N-methylaniline

: 1-tert-butoxy-3-(methyl-phenyl-amino)-propan-2-ol

Conditions

Conditions	Yield
With aluminium(III) triflate In toluene at 100℃; for 5h;	91%

: 7665-72-7
t-butyl glycidyl ether

: 22576-65-4
1-chloro-3-tert-butoxy-2-propanol

Conditions

Conditions	Yield
With lithium chloride; 1-hexyl-3-methylimidazolium perchlorate at 60℃; for 3h;	90%

: 7665-72-7
t-butyl glycidyl ether

: 74338-98-0
3-(tert-butoxy)propane-1,2-diol

Conditions

Conditions	Yield
With water at 100℃;	90%

: 7665-72-7
t-butyl glycidyl ether

: 106-49-0
p-toluidine

: 1178176-76-5
C14H23NO2

Conditions

Conditions	Yield
With BiCl6(3-)2C4H10N2ClH3H(1+)H2O at 20℃; for 0.1h; Neat (no solvent); regioselective reaction;	89%

: 7665-72-7
t-butyl glycidyl ether

: 141-32-2
acrylic acid n-butyl ester

: 507-09-5
thioacetic acid

: butyl 3-{[2-(acetyloxy)-3-isopropoxypropyl]sulfanyl}propanoate

Conditions

Conditions	Yield
Stage #1: t-butyl glycidyl ether; tiolacetic acid In neat (no solvent) at 80℃; for 0.5h; Michael Addition; Stage #2: acrylic acid n-butyl ester With aluminum oxide In neat (no solvent) at 20℃; Michael Addition;	89%

...Expand

: 7665-72-7
t-butyl glycidyl ether

: 841-77-0
diphenylmethylpiperazine

: 901663-31-8
1-(4-benzhydrylpiperazin-1-yl)-3-tert-butoxypropan-2-ol

Conditions

Conditions	Yield
Stage #1: t-butyl glycidyl ether; diphenylmethylpiperazine With aluminium(III) triflate In toluene at 70℃; for 5h; Stage #2: With sodium hydrogencarbonate In water; toluene regioselective reaction;	88%

: 7665-72-7
t-butyl glycidyl ether

: 536-74-3
phenylacetylene

: 1-(tert-butoxy)-3-(4-phenyl-1H-1,2,3-triazol-1-yl)propan-2-ol

Conditions

Conditions	Yield
With sodium azide In water at 70℃; for 3.25h; Catalytic behavior; Sonication; regioselective reaction;	88%

: 7665-72-7
t-butyl glycidyl ether

: 106-47-8
4-chloro-aniline

: 1184609-97-9
C13H20ClNO2

Conditions

Conditions	Yield
With BiCl6(3-)2C4H10N2ClH3H(1+)H2O at 20℃; for 0.116667h; Neat (no solvent); regioselective reaction;	87%

: 7665-72-7
t-butyl glycidyl ether

: 314741-40-7
(3S)-3-(hydroxymethyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester

: (3S)-tert-butyl 4-(3-(tert-butoxy)-2-hydroxypropyl)-3-(hydroxymethyl)piperazine-1-carboxylate

Conditions

Conditions	Yield
In ethanol at 120℃; for 0.5h; Microwave irradiation;	87%

: 7665-72-7
t-butyl glycidyl ether

: 98-91-9
thiobenzoic acid

: 141-32-2
acrylic acid n-butyl ester

: 2-[(3-butoxy-3-oxopropyl)sulfanyl]-1-(isopropoxymethyl)ethyl benzoate

Conditions

Conditions	Yield
Stage #1: t-butyl glycidyl ether; thiobenzoic acid In neat (no solvent) at 80℃; for 0.5h; Michael Addition; Stage #2: acrylic acid n-butyl ester With aluminum oxide In neat (no solvent) at 20℃; Michael Addition;	87%

...Expand

: 7665-72-7
t-butyl glycidyl ether

: C3H6O*CLiN

: 141077-80-7
4-(tert-butoxy)-3-hydroxybutanenitrile

Conditions

Conditions	Yield
In tetrahydrofuran for 0.25h; Heating;	86%

: 7665-72-7
t-butyl glycidyl ether

: 151-50-8
potassium cyanide

: 141077-80-7
4-(tert-butoxy)-3-hydroxybutanenitrile

Conditions

Conditions	Yield
salcomine In ethylene glycol at 20℃; for 2.5h;	85%

: 7665-72-7
t-butyl glycidyl ether

: 615-37-2
ortho-methylphenyl iodide

: C14H20O2

Conditions

Conditions	Yield
With (2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2’-methylamino-1,1’-biphenyl)]palladium(II) methanesulfonate; C11H16O2; sodium acetate In N,N-dimethyl-formamide at 120℃; for 24h; Inert atmosphere; Glovebox;	85%

: 7665-72-7
t-butyl glycidyl ether

: 104-94-9
4-methoxy-aniline

: 1183330-72-4
C14H23NO3

Conditions

Conditions	Yield
With BiCl6(3-)2C4H10N2ClH3H(1+)H2O at 20℃; for 0.133333h; Neat (no solvent); regioselective reaction;	84%

: 7665-72-7
t-butyl glycidyl ether

: 4648-54-8
trimethylsilylazide

: 1-azido-2-trimethylsilyloxy-3-t-butoxy propane

Conditions

Conditions	Yield
aluminum isopropoxide In dichloromethane for 24h; Ambient temperature;	82%
aluminum isopropoxide In dichloromethane for 24h; Ambient temperature;	82%

: 7665-72-7
t-butyl glycidyl ether

: 103-84-4
Acetanilid

: C15H23NO3

Conditions

Conditions	Yield
With palladium diacetate; acetic acid at 60℃; regioselective reaction;	80%

: 7665-72-7
t-butyl glycidyl ether

: 1576-44-9
N-nosylaniline

: 1-(tert-butoxy)-3-((4-nitrophenyl)(phenyl)amino)propan-2-ol

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 70℃; for 4h; Smiles Aromatic Rearrangement;	80%

: 7665-72-7
t-butyl glycidyl ether

: 6325-93-5
p-nitrobenzenesulfonamide

: 1-(tert-butoxy)-3-((4-nitrophenyl)amino)propan-2-ol

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 70℃; for 4h; Smiles Aromatic Rearrangement;	79%

tert-BUTYL GLYCIDYL ETHER Chemical Properties

Synonyms: 1-TERT-BUTOXY-2,3-EPOXYPROPANE;(TERT-BUTOXYMETHYL)OXIRANE;TERT-BUTYL GLYCIDYL ETHER;TBGE;T-BUTYL GLYCIDYL ETHER;((1,1-dimethylethoxy)methyl)-oxiran;((1,1-Dimethylethoxy)methyl)oxirane;[(1,1-dimethylethoxy)methyl]-oxiran
EINECS: 231-640-0
Melting point: -70°C
Boiling point: 150-152 °C
Fp: 55°C
refractive index: n20/D 1.417(lit.)
density: 0.917 g/mL at 25 °C(lit.)

tert-BUTYL GLYCIDYL ETHER is the chemical compound with the formula C₇H₁₄O₂ .Its molar mass is 130.18 g/mol .

tert-BUTYL GLYCIDYL ETHER Toxicity Data With Reference

1.	mmo-sat 333 µg/plate	MUREAV Mutation Research. 172 (1986),105.
2.	bfa-mus:sat 500 mg/kg/5D-I	ENMUDM Environmental Mutagenesis. 2 (1980),284.
3.	orl-rat LD50:2 g/kg	38MKAJ Pattys Industrial Hygiene and Toxicology 3rd rev. ed.,Clayton, G.D., andF.E. Clayton, eds.,New York, NY.: John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985 2A ,1981,2202.

tert-BUTYL GLYCIDYL ETHER Consensus Reports

tert-BUTYL GLYCIDYL ETHER is reported in EPA TSCA Inventory.

tert-BUTYL GLYCIDYL ETHER Safety Profile

Suspected carcinogen. Moderately toxic by ingestion. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating vapors.

Risk Statements : 10: Flammable ;19: May form explosive peroxides ;22: Harmful if swallowed ;36: Irritating to the eyes ;43: May cause sensitization by skin contact
Safety Statements : 16: Keep away from sources of ignition - No smoking ;26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice ; 36/37: Wear suitable protective clothing and gloves .
Hazard Codes : Xn
RIDADR : UN 3271 3/PG 3
WGK Germany : 3

tert-BUTYL GLYCIDYL ETHER Standards and Recommendations

DFG MAK: Confirmed Animal Carcinogen with Unknown Relevance to Humans

Product Name

TERT-BUTYL GLYCIDYL ETHER

Synthetic route

tert-BUTYL GLYCIDYL ETHER Chemical Properties

tert-BUTYL GLYCIDYL ETHER Toxicity Data With Reference

tert-BUTYL GLYCIDYL ETHER Consensus Reports

tert-BUTYL GLYCIDYL ETHER Safety Profile

tert-BUTYL GLYCIDYL ETHER Standards and Recommendations

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