Reaction of 5,5,5-trifluoro-4-(trifluoromethyl)penta-3-en-2-one (1) with p-toluene-sulfonylhydrazines under basic conditions provided anti-Michael addition products. Acid-catalyzed reactions yielded the expected hydrazones. In the absence of solvent the reaction of (CH3)3SiCl with 1 gave the cor...
Selected imines reacted with hexafluoroacetone non-catalyzed at ambient temperature to give β-hydroxy-β-bis(trifluoromethyl) imines in good to excellent yields. For the imines of acetone, pentan-3-one, and of cyclohexanone a 1:2 reaction was observed giving iminodiols; for N,N′-bis(propyliden...
The involvement of cell membrane fatty acids in resistance of Pseudomonas aeruginosa to Quaternary Ammonium Compounds (QACs) stresses was investigated. The strain was grown in a medium with increasing concentrations of different biocides: two QACs, and two non-QACs. In the presence of two QACs o...
Simultaneous profiling analysis of urinary amino acids (AAs) and carboxylic acids (CAs) was combined with retention index (I) analysis for graphic recognition of abnormal metabolic state. The temperature-programmed I values of the AA and CA standards measured as ethoxycarbonyl (EOC)/methoxime (M...
Cytochrome P450 BM-3 (CYP102) catalyzes the subterminal hydroxylation of fatty acids with a chain length of 12–22 carbons. The paper focuses on the regioselectivity and substrate specificity of the purified wild-type enzyme and five mutated variants towards caprylic, capric, and lauric acid. Th...
Publisher SummaryThis chapter discusses the ω– and (ω-l)–hydroxylation of fatty acids in rabbit intestinal mucosa microsomes. It has been found that fatty acids are rapidly converted to ω– and (ω-l)–hydroxy fatty acids in the microsomes from rabbit intestinal mucosa that had been washed ...
A novel carbonyl reductase from Serratia marcescens, SmCR, was successfully cloned and overexpressed in Escherichia coli. SmCR could catalyze the asymmetric reduction of long-chain keto acids/esters containing remote carbonyl groups, such as 4-oxo- and 5-oxodecanoic acids, yielding chiral γ- an...
A reverse phase high performance liquid chromatography (HPLC) method was developed for the simultaneous determination of codeine (methyl morphine) and dionin (ethyl morphine hydrochloride) in antitussive analgesic tablet formulations. A C18 column and methanol–water (1:2) mixture mobile phase (...
A new electrochemical sensor for codeine was fabricated based on composite graphene and Nafion film modified glassy carbon electrode. It was found that the electrochemical response of this sensor was greatly improved and displayed excellent analytical performance for codeine detection, which cou...
Considering the enzymatic activity of the cytochrome P450 2D6 on substrates such as codeine, the current paper includes the development of an enzymatic biosensor for detection of this drug. Home-made screen-printed electrodes were used as electrochemical transducers of the biosensor, in which th...
Postoperative pain and inflammation after oral surgery is mostly managed using non-steroidal anti-inflammatory drugs (NSAIDs). However, opioids combined with NSAIDs may improve pain management in patients, especially after traumatic oral surgery. Few studies have compared NSAIDs with and without...
Two binary mixtures containing codeine (COD) with either ibuprofen (IBU), mixture 1, or with phenylephrine hydrochloride (PE), mixture 2, were analyzed using three simple eco-friendly spectrofluorimetric methods without the need to a prior separation step. The first method is derivative emission...
BackgroundThe non-medical use of pharmaceutical opioids such as codeine is of increasing public health concern. The aim of the study was to describe codeine intoxication experiences amongst recreational drug users, as posted on public Internet forums.
PurposeThe aim of this study was to compare the clinical efficacies of naproxen sodium–codeine phosphate in combination, benzydamine hydrochloride, and diclofenac potassium for pain, edema, and trismus after lower third molar extraction.
An HPLC method using UV detection is proposed for the simultaneous determination of pseudophedrine hydrochloride, codeine phosphate, and triprolidine hydrochloride in liquid formulation. C18 column (250 mm × 4.0 mm) is used as the stationary phase with a mixture of methanol:acetate buffer:aceto...
pH-Sensitive poly(N,N-dimethylaminoethyl methacrylate (DMAEMA)/2-hydroxyethyl methacrylate (HEMA)) nanoparticles were prepared for the triggered release of paclitaxel within a tumor microenvironment. Tumors exhibit a lower extracellular pH than normal tissues. We show that paclitaxel release fro...
N-(2-dimethylaminoethyl)acetohydroxamic acid was synthesized. This compound, which incorporates a dimethylamino group as a second functionality into the hydroxamic acid molecule, catalyzes the hydrolysis of p-nitrophenyl acetate faster than acetohydroxamic acid itself does. The function of the d...
Three amphiphilic random copolymers poly(2-(dimethylaminoethyl)methacrylate-co-alkylacrylate) (where, alkyl = hexyl, octyl, dodecyl) with 16 mol% hydrophobic substitution were synthesized. Surface tension, viscosity, fluorescence probe, dynamic light scattering (DLS), as well as transmission ele...
Multi-walled carbon nanotubes (MWNTs) were functionalized with poly(2-dimethylaminoethyl methacrylate) (PDMAEMA) in a nondestructive manner by UV-driven surface-initiated reversible addition fragmentation chain transfer (RAFT) polymerization. The RAFT agent having benzophenone groups was initial...
Radical copolymerizations of cationic, surface-active monomers, such as lauryl (C12Br), octyl (C8Br) and cetyl (C16Br) bromide salts of 2-dimethylaminoethyl methacrylate with methyl methacrylate (MMA) or styrene (ST) have been studied in water and N,N-dimethylformamide (DMF) as solvent, giving a...
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