Bovine serum albumin (BSA) was utilized to assemble with the binary complexes of poly(vinylpyrrolidone)-graft-poly(2-dimethylaminoethyl methacrylate) (PVP-g-PDMAEMA)/DNA formed by layer-by-layer electrostatic interactions to screen the residual surface positive charges of complexes. The coating ...
Reducible polycations represent promising carriers of therapeutic nucleic acids. Oligomers of 2-dimethylaminoethyl methacrylate (DMAEMA) containing terminal thiol groups were synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization using difunctional chain transfer a...
Linear amphiphilic diblock copolymers of polylactide (PLA) and poly(2-dimethylaminoethyl methacrylate) (PDMAEMA) were synthesized by atom transfer radical polymerization (ATRP) of DMAEMA followed by ring-opening polymerization (ROP) of LLA using the bifunctional initiator, 2′-hydroxyethyl 2-bro...
Amabeoku, George and Raymond Chandomba: Strychnine-induced seizures in mice: the role of noradrenaline. Prog. Neuro-psyohopharmacol. & Biol. Psychiat. 1994, 18: 3 753–763.1. The effects of some noradrenergic agents on seizures induced by strychnine were investigated in mice.2. Strychnine (0.5–...
A simple and rapid method based on solid phase microextraction (SPME) via direct immersion followed by gas chromatography coupled with electron impact ionization/mass spectrometry (GC/EI-MS) was developed for the determination of strychnine in blood. Papaverine was used as internal standard (I.S...
A reversed-phase ion-pair chromatographic method was developed for the simultaneous determination of yohimbine hydrochloride (YOH), strychnine nitrate (SN) and methyltestosterone (MT) in a pharmaceutical preparation (tablet). YOH, SN and MT were extracted and separated within 15 min on an octade...
EL HANI, A., J. R. MASON, D. L. NOLTE AND R. T. SCHMIDT. Flavor Avoidance learning and its implications in reducing strychnine baiting hazards to non-target animals. PHYSIOL BEHAV 64 (5) 585–589, 1998.—In reforested areas, underground strychnine baiting to control pocket gophers (Thomomys maza...
A mixed matrix membrane (MMM), based on carbon nanotubes (CNTs) and hollow fiber (HF), was prepared and combined with solid phase microextraction (SPME) mode to determine strychnine and brucine in urine. This MMM was prepared by dispersing CNTs in water via surfactant assistance, and then immobi...
A rapid, specific and sensitive liquid chromatography–tandem mass spectrometric (LC–MS/MS) method was developed and validated for the simultaneous determination of strychnine, brucine, strychnine N-oxide and brucine N-oxide in rat plasma. Plasma samples were pretreated via simple protein preci...
Structural aspects such as chemical exchange, dimerization, solvent association, nitrogen inversion and protonation status of strychnine were investigated using experimental and calculated data. The information was mainly interpreted in view of a successful determination of the absolute configur...
Strychnos nux-vomica L. has been frequently used in traditional Chinese medicine but has high acute toxicity. It is commonly taken with Glycyrrhizae radix to decrease its toxicity but the mechanism of this interaction is unknown. In this work, the mRNA expression and the activity of four cytochr...
Amidephrine, a phenethanolamine with a methylsulfonamido radical at them-position on the benzene ring, exhibited sympathomimetic effects attributable to selective stimulation of the adrenergic α-receptor. The effects included (1) high affinity for isolated tissues classically identified as prom...
Amidephrine mesylate, a new potent sympathomimetic amine, was compared with phenylephrine using several cardiovascular preparations. The vasopressor molar potency (amidephrine: phenylephrine) was as follows: anesthetized dogs (i.v.) 1:·9; anesthitized cats (i.v.) 1:2·1; unanesthetized rats (i....
The α-adrenoceptor activity of (−)-amidephrine in the isolated vas deferens of the rat was characterized. In this preparation (−)-amidephrine showed a selective activity on α1-adrenoceptors, and failed to exert any effect on α2-adrenoceptors. The α1-adrenoceptors antagonists prazosin (pA2 8....
The acute toxicity of amidephrine mesylate was examined in mice, rats, rabbits, dogs, monkeys and cats and compared with that of phenylephrine hydrochloride in mice. Amidephrine was less toxic than phenylephrine, and with both agents the effects were those of adrenergic stimulation. Amidephrine ...
To study the effect of varied intestinal delivery of levodopa ester, levodopa and its butyl ester were administered as bolus or continuous infusions into site-specific, in situ ligated intestinal loops of rats. Benserazide, a carboxylase inhibitor, was not administered, coadministered with ester...
Mice were treated for 28 days with drinking water containing L-DOPA methyl ester hydrochloride (DME) plus carbidopa, carbidopa alone, or with the vehicle. All mice were then given the vehicle for 1 day and behavioural and biochemical assessments made on the 29th day. On average, mice consumed be...
A sensitive, accurate and reproducible method has been developed for the determination of free and conjugated catecholamines and l-3,4-dihydroxyphenylalanine in plasma and urine. The assay involves the enzymatic conversion of these compounds to their radio-labelled O-methylated derivatives using...
We have proposed that L-3,4-dihydroxyphenylalanine (L-DOPA) is a neurotransmitter in the central nervous system [Y. Misuet al. (1995)Adv. Pharmac.32, 427–459]. L-DOPA as a probable neurotransmitter for the primary baroreceptor afferents tonically functions to mediate cardiodepressor control in ...
l-3,4-Dihydroxyphenylalanine (DOPA) is a neurotransmitter candidate. To map the DOPAergic system functionally, DOPA-induced c-Fos expression was detected under inhibition of central aromatic l-amino acid decarboxylase (AADC). In rats treated with a central AADC inhibitor, DOPA significantly incr...
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