Our previous study implied the role of central high mobility group box 1 (HMGB1) in lipopolysaccharide (LPS)-induced depressive-like behaviors that could partially abrogate by glycyrrhizic acid (GZA). Here, we considered the potential mechanism underlying GZA ameliorating chronic stress-induced ...
Efforts were made to improve the bioavailability and efficacy of Glycyrrhizic acid, a triterpentine saponin obtained from Glycyrrhiza glabra, having several pharmacological properties, by its encapsulation in biocompatible biopolymeric nanoparticles. Polycationic chitosan and polyanionic gum kat...
Superheated water extraction (SWE) has become an interesting green extraction method for different classes of compounds. In this study, SWE was used to extract glycyrrhizic acid (GA) from licorice root. Response surface methodology (RSM) was applied to evaluate and optimize the extraction condit...
The cDNA clone of restrictocin was placed under the control of the glucoamylase promoter from Aspergillus awamori and was transformed into Aspergillus nidulans and Aspergillus niger. Site-specific changes were introduced into cDNA constructs and these were transformed into A. nidulans. The secre...
Restrictocin, a toxin produced by the fungusAspergillus restrictus,is a potent inhibitor of eukaryotic protein synthesis. Recombinant restrictocin was made inEscherichia coliand purified to homogeneity in large amounts. The recombinant protein was found to be poorly immunogenic in mice with low ...
Background: Restrictocin, a highly specific ribotoxin made by the fungus Aspergillus restrictus, cleaves a single phosphodiester bond in the 28S RNA of eukaryotic ribosomes, inhibiting protein synthesis. The sequence around this cleavage site is a binding site for elongation factors, and is cons...
Targeted toxins represent a new approach to specific cytocidal therapy. The ribonucleolytic protein toxin restrictocin is a potent protein synthesis inhibitor produced by the fungus Aspergillus restrictus. In the present study we have constructed two restrictocin based chimeric toxins where huma...
Restrictocin is a toxin produced by the fungus Aspergillus restrictus. The DNA coding for restrictocin was isolated from the host by polymerase chain reaction and cloned into a T7 promoter-based expression vector. The protein was overproduced in Escherichia coli and remained insoluble in the cel...
Restrictocin is a 149 amino acid ribonucleolytic toxin produced by the fungus Aspergillus, which specifically cleaves a single phosphodiester bond within 28S rRNA resulting in a potent inhibition of protein synthesis in eukaryotic cells. Restrictocin has 12 prolines out of which three at positio...
A series of contiguous deletions were made in a cDNA encoding the ribonuclease restrictocin with the purpose of identifying the amino acids that are essential for the cleavage of the phosphodiester bond on the 3′ side of G4325 in the α-sarcin/ricin domain of mammalian (rat) 28S rRNA. In all 93...
Restrictocin, a highly specific ribonuclease produced by Aspergillus restrictus, cleaves a single phosphodiester bond in a universally conserved stem and loop structure termed sarcin/ricin loop within the large ribosomal RNA of all organisms. In the current study, we demonstrate restrictocin to ...
Background: Splanchnic artery occlusion shock is caused by increased capillary permeability and cellular injury precipitated by oxygen derived free radicals following ischemia and reperfusion of splanchnic organs. The purpose of this study was to assess the role of several wellknown oxygen-deriv...
To study the fate of intravenously infused vitamin E, we infused lipid emulsions rich in γ-tocopherol (Intralipid, Kabi, Stockholm, Sweden), or in both α- and γ-tocopherols (Lipidem, Hausmann Laboratories, St Gallen, Switzerland); in normal human volunteers. Plasma γ-tocopherol levels increa...
The purpose of this study was to examine the effect of dietary tocopherols on the oxidative stability of Atlantic salmon fillet. The fish were fed four diets supplemented with 150mg kg−1 α-tocopherol and different combinations of γ- and δ-tocopherol (50 or 100mgkg−1) for 10 months, slaughtere...
Retinol, tocopherols and carotenes were extracted from walnut kernels. Three walnut extraction procedures were compared. Direct hexane extraction was selected. The fat-soluble vitamin separation was achieved by reversed-phase high performance liquid chromatography equipped with a ternary mobile ...
The effect of alpha tocopherol supplementation on serum hormones was studies in women with clinically confirmed mammary dysplasia and age-matched controls. Serum samples collected at monthly intervals on the 21st day of the menstrual cycle for a period of four months were analyzed for estradiol,...
Exposure of the skin of the back of skh-1 hairless mice to UVB (310 nm peak) irradiation at doses of 0.115–0.23 J/cm2 results after 24–48 h in an erythema which can be quantified using an erythema meter, providing a useful model of sunburn. Application of pure d-α-tocopherol acetate, a thick ...
We have previously reported the isolation of a vitamin E analog (α-tocopherol succinate) from a green barley leaf extract, which stimulates the release of prolactin and growth hormone from rat anterior pituitary cells in vitro. In the present study, we tested the commercially available forms of...
Upon oxidation in aprotic media, β-tocopherol (2) forms a spiro-dimer (10) as the main product. The reaction mechanism is a hetero-Diels–Alder process with inverse electron demand of two intermediate ortho-quinone methide molecules. The spiro-dimer can be reduced to the corresponding symmetric...
Now is a very exciting time for those people who are interested in understanding oxygenic photosynthesis driven by longer wavelength radiation. The past two decades have seen the determination of molecular mechanisms of photosynthesis driven by long wavelengths. Apart from the characterization o...
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