ObjectiveThiethylperazine is a commonly used anti-emetic drug during pregnancy in Hungary. One experimental study in mice and rats found an increased occurrence of cleft palate after the use of thiethylperazine during pregnancy but the human data of thiethylperazine have not been reported. Thus,...
Thiethylperazine (Maleate), a phenothiazine derivative, is a sedating antihistamine used as an antiemetic agent for the control of nausea and vomiting associated with surgical procedures …
Decamethonium (C10) is a bisquaternary methonium compound with selectivity for blockade of the muscle nicotinic acetylcholine receptor. It produces a depolarizing type of neuromuscular blockade and does not affect ganglionic nicotinic receptors. Its actions are similar to those of succinylcholin...
Desacetamidocolchicine (3) and desacetamidoisocolchicine (4) have been chromatographically resolved into enantiomers. Thermal racemization gives inversion barriers of 22.1 and 23.4 kcal mol−1, respectively, for rotation around the bond joining the two aromatic rings. Kinetic binding experiments ...
The reaction of `DNBP' (2,4-dinitro-6-sec-butylphenol) with toluene, ethylbenzene or styrene and tert-butylperoxide at 110°C leads to 7-sec-butyl-5-nitro-2-phenylbenzoxazole. This benzoxazole was also detected in the residues of an industrial styrene fractionation still in which DNBP was r...
Background & AimsDrug repositioning offers a shorter approval process than new drug development. We therefore searched large public datasets of drug-induced gene expression signatures to identify agents that might be effective against hepatocellular carcinoma (HCC).
We have found that niclosamide induced relaxation of constricted artery. However, niclosamide is insoluble, the low bioavailability and the resultant low plasma concentration limit its potential exertion in vivo. The aim of the present study is to synthesize a soluble poly (methacrylic acid-nicl...
Niclosamide is an oral antihelminthic drug used to treat parasitic infections in millions of people worldwide. However recent studies have indicated that niclosamide may have broad clinical applications for the treatment of diseases other than those caused by parasites. These diseases and sympto...
A method using LC–MS/MS after QuEChERS preparation for the simultaneous determination of metaldehyde and niclosamide ethanolamine residues in soil and pakchoi has been developed and validated. The mean recoveries were ranged from 90% to 101% with RSDs (relative standard deviations) less than 9....
We previously demonstrated that the typical mitochondrial uncoupler carbonyl cyanide m-chlorophenylhydrazone (CCCP) inhibited artery constriction, but CCCP was used only as a pharmacological tool. Niclosamide is an anthelmintic drug approved by FDA. Niclosamide ethanolamine (NEN) is a salt form ...
Nonalcoholic steatohepatitis (NASH) is a common liver disease associated with metabolic disorders, including obesity and type 2 diabetes (T2D). Despite its worldwide prevalence, there are no effective drugs for the treatment of NASH. The progression of NASH is mainly accelerated by reactive oxyg...
AimsEarly diabetic kidney disease (DKD) is characterized by renal hypertrophy and albuminuria. The mTOR signal pathway is closely related to DKD. This study was performed to determine the renal protection of niclosamide ethanolamine salt (NEN) which was identified as mTOR inhibitor.
Our previous study found that the anthelmintic drug niclosamide relaxed the constricted arteries and inhibited proliferation and migration of vascular smooth muscle cells. Here, we investigated the effect of niclosamide ethanolamine (NEN) on trachea function and the proliferation and migration o...
The protein moiety of chicken iodopsin, R-photopsin, was purified from the chicken retina using a sucrose flotation method followed by two steps of column chromatography. Apparent molecular weights of R-photopsin and scotopsin (the protein moiety of chicken rhodopsin), which was partly purified ...
Monoclonal antibodies (mABs) from hyridoma cells were raised and screened with a purified cone pigment, iodopsin, from the chicken retina. Four different methods were used to test these antibodies:(1) dot-immunobinding assay;(2) enzyme-linked immunoabsorbent assay (ELISA);(3) one dimensional imm...
Activation of guanosine 3′,5′-cyclic monophosphate phosphodiesterase in outer-segment membrane of chicken retina was investigated. Irradiation of dark-adapted chicken outer segment membrane for bleaching of iodopsin increased the enzyme activity twice as much as that in the dark in the presenc...
The thermal reaction of meta I-intermediate of iodopsin (metaiodopsin I), a chicken red-sensitive cone pigment, was studied by low-temperature spectrophotometry at −20°C. Irradiation of iodopsin at −20°C produced metaiodopsin I, whose absorption maximum was at about 470 nm. An incubation of me...
Iodopsin, a dominant cone pigment in a chicken retina, has an absorption spectrum in longer wavelength region than rhodopsin. To account for this red-shift of iodopsin, we had proposed a structural model from retinal analogue experiments, in which iodopsin would have a relatively long distance b...
Carbendazim (CBZ) is a systemic fungicide utilized for the control fungal diseases in forestry and agricultural crops. Its severe toxicity and residual nature mandated its removal and biodegradation by biological, eco-friendly and sustainable methods. Towards this direction, we searched for CBZ ...
Fluoroquinolones (FQs) are widely used in human and veterinary medicaments, and as such are ubiquitous environmental contaminants. Dissolved organic matter (DOM) is widely distributed in natural water and sediment and dissolved humic acid (DHA) is a major component of DOM. The coexistence of DHA...
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