Reaction of Cp2LnNHnBu with 1 equiv. of Ph2CCO in toluene affords dimeric complexes [Cp2Ln(OC(CHPh2)NnBu)]2 [Ln = Yb (1), Dy (2)], derived from a formal insertion of the CC bond of the ketene into the N–H bond. Treatment of CpErCl2 with 2 equiv. of LiNHnBu followed by reacting with Ph2CCO affor...

This work deals with the synthesis of two mixed binary chiral selectors prepared by grafting (l)- or (d)-valine tert-butylamide on permethylated cyclodextrin macrocycle. The enantioselective properties of the new chiral selectors diluted in OV11 polysiloxane (35% phenyl- and 65% methylsiloxane) ...

Butylamide-terminated poly(amidoamine) dendrons with either a Boc group (C-n (n = 1, 2, 3)) or a carboxyl group (E-n (n = 1, 2)) at the focal point, as a new kind of dendritic gelators, were synthesized and their gelation properties were studied by TEM, WAXD, SAXS, NMR,and FTIR spectroscopy. It ...

A one-pot synthesis of 1-hydroxymethyl-3-aminomethyl indoles 3 could be achieved in excellent yield by reacting indoles 1 with formaldehyde and secondary amines 2 in the presence of molecular sieves (3 Å) and catalytic amount of InCl3 (10 mol %) in 1,4-dioxane at room temperature for 3–5 h.

A simple electrochemical sensor for detecting dopamine was fabricated using 1,4-bis(aminomethyl)benzene (BAMB) and cobalt hydroxide (Co(OH)2) at graphene oxide (GO) surface using a simple solution-based chemical reduction method. The successful formation of GO-BAMB-Co(OH)2 was confirmed by trans...

In order to provide a direction in molecular design toward creating a highly-sensitive fluorescence PET (photo-induced electron transfer) sensor for a trace amount of water in organic solvents, we have designed and synthesized anthracene-bis(aminomethyl)phenylboronic acid ester OA-1 and OA-2, wi...

The cyclocondensation of aminomethyl-1,2,4-triazoles and glyoxal gives hexahydropyrazino[2,3-e]pyrazines in good yields. 1H and 13C NMR spectra of the title compounds are described and the molecular structure of 4a,5,6,10a,11,12-hexahydro-(4aR,10aR)-[1,2,4]triazolo[1,5-a][1,2,4]triazolo[1′,5′:...

(S)-3-Cyano-5-methylhexanoic acid ethyl ester is a valuable synthetic intermediate for pregabalin. Immobilized lipase PS from Pseudomonas cepacia was screened and shown to be the best biocatalyst for the enantioselective hydrolysis of 3-cyano-5-methylhexanoic acid ethyl ester, a racemic mixture ...

A series of novel 2-amino-3-cyano-6-(1H-indol-3-yl)-4-phenylpyridine derivatives were synthesized and their cytotoxic activity against A549, H460, HT-29 and SMMC-7721 cell lines was evaluated in vitro. Among them, ten compounds (10, 11, 14, 16, 17, 26, 27, 29, 30 and 31) displayed excellent anti...

Selective targeting of cancer cells over normal cells is a key objective of targeted therapy. However few approaches achieve true mechanistic selectivity resulting in debilitating side effects and dose limitation. In this work we describe the discovery of A131 (4a), a new agent with an unprecede...

2-Oxo-4-(2′-phenyl-5′-substituted 1H-indol-3′-yl)-6-phenylpyridin-3-carbnitriles (2a–c) and its derivatives containing 1,2,4-triazole (4a–c), thiazolo[3,2-b][1,2,4]triazole (5a–c), hydrazide (6a–c), pyrazolones (7a–c) and (8a–c) were synthesized. Structures of all these previously unkno...

Recent developments in high-magnetic field/high-frequency electron magnetic resonance (HMF-EMR) techniques offer improved capabilities for determination of the spin Hamiltonian (SH) parameters, including the fourth-rank zero field splitting (ZFS) parameters (ZFSPs) for spin S̃ = 2 systems. Howev...

Background2-hydroxy-3-methylanthraquinone (HMA), an anthraquinone monomer in traditional Chinese medicine Hedyotis diffusa, has been reported to inhibit the growth of several types of cancer, but its effect on lung cancer has not been adequately investigated.

In mares, placental diseases are a common cause of pregnancy failure and they can have an economic impact on the horse breeding industry. To our knowledge no published data on TLR expression in the equine placenta exist. This study examined the expression of TLR 2, 4 and 6 as transcript and prot...

The concerns about the undesired impacts on human health and the environment of long chain perfluorinated alkyl substances (PFASs) have driven industrial initiatives to replace PFASs by shorter chain fluorinated homologues. 6:2 fluorotelomer sulfonic acid (6:2 FTSA) is applied as alternative to ...

6:2 fluorotelomer sulfonic acid (6:2 FTSA) is currently used as an alternative to perfluorooctanesulfonate (PFOS) and is widely detected in the environment. The uptake, translocation and biotransformation of 6:2 FTSA in pumpkin (Cucurbita maxima L.) were investigated by hydroponic exposure for t...

2, 4, 6-Trinitrotoluene (TNT) is a frequently used explosive compound, and it easily gathers in soil and water during transportation, use, and storage. Except for the security issue, it also has high toxicity and mutagenic effect on the environment and all life forms. Thus, it is critical to dev...

6:2 fluorotelomer sulfonamidoalkyl betaine (6:2 FTAB) is a major component of aqueous film-forming foams (AFFFs) used for firefighting and is frequently detected, along with one of its suspected transformation products, 6:2 fluorotelomer sulfonate (6:2 FTSA), in terrestrial and aquatic ecosystem...

2-(5-Arylpyridine-2-yl)-6-(het)arylquinoline-based “push-pull” fluorophores were synthesized by means of the heterocyclization reaction between the corresponding isonitrosoacetophenone hydrazones and 6-bromoquinoline-2-carboxaldehyde followed by an aza-Diels-Alder/Suzuki cross-coupling reactio...

The purpose of the present study attempt to investigate the antioxidant and antimicrobial activities of isolated bioactive compound from ethanolic extract of Euclea crispa (E. crispa) leaves. Column chromatography method was used to isolate the bioactive compound from the plant leaves followed b...