Pioglitazone has been used for the treatment of nonalcoholic fatty liver disease (NAFLD) related to diabetes. The role of adiponectin in pioglitazone-induced improvements in NAFLD was studied by using wild-type (adipoWT) and adiponectin knockout (adipoKO) mice. High-fat diet fed mice were insuli...

PC-3 cells, a metastatic human prostate adenocarcinoma line, caused dose-dependent platelet aggregation in heparinised human platelet-rich plasma (PRP). PC-3 tumour cell-induced platelet aggregation (TCIPA) was completely inhibited by hirudin (5 UIml) and limited by increasing concentrations of ...

Trigramin, a cysteine-rich, RGD-containing peptide isolated from the venom of the Trimeresurus gramineus snake, inhibited the adhesion of human melanoma cells to fibronectin and fibrinogen. Compared on a molar basis to GRGDSP, trigramin was approximately 500 times more potent than the hexapeptid...

“A sulfated polysaccharide from Monostroma nitidum Wittrock (Ulvophyceae)” was purified by anion-exchange and gel filtration column chromatographies. The isolated polysaccharide consisted of large amount of l-rhamnose with small amount of d-glucose, and it was regarded to be a rhamnan sulfate ...

Three sulfated rhamno-oligosaccharides, designated O1, O2 and O3, were obtained by mild acid hydrolysis of the sulfated rhamnan and purified by gel-permeation chromatography. On the basis of one- and two-dimensional nuclear magnetic resonance (1D, 2D NMR) spectroscopic analyses, the oligosacchar...

Rhamnan sulfate from cell walls of Monostroma latissimum was purified through subsequent chromatographic systems. The purified polysaccharide consisted of large amounts of rhamnose residues and appeared to be an entire homopolysaccharide. Antithrombin activity was lower than rhamnan sulfate prev...

A low molecular weight fraction, designated LMWP, was prepared by mild acid hydrolysis of sulfated rhamnan from Monostroma latissimum and purified by anion-exchange and gel-permeation chromatography. Chemical and spectroscopic analyses showed that LMWP was mainly composed of rhamnose, and its mo...

A homogeneous polysaccharide was obtained from Monostroma angicava Kjellm by water extraction, preparative anion-exchange and size-exclusion chromatography. Results of chemical and spectroscopic analyses showed that the polysaccharide was a glucuronic acid-containing rhamnan-type sulfated polysa...

The total synthesis of the α‐mannans, α‐rhamnans, β‐mannans, and β‐rhamnans is presented according to the overall strategy employed. The α‐mannans and α‐rhamnans are discussed in terms of the use of use or not of neighboring‐group participation to construct the 1,2‐trans‐axial gly...

Rhamnan sulphate (RS) is a sulphated polysaccharide from Monostroma nitidum. Here, the effects of RS on metabolic disorders using zebrafish with diet-induced obesity (DIO) were investigated. Oral administration of RS (250 µg/g BW/day) attenuated body weight gain, dyslipidaemia (plasma triacylgl...

Polysaccharide from Monostroma latissimum PML is a sulfated rhamnan, which consists of →3)-α-L-Rhap-(1→ and →2)-α-L-Rhap-(1→ residues with partial branches and sulfate groups at C-2 of →3)-α-L-Rhap-(1→ and/or C-3 of →2)-α-L-Rhap-(1→. The anti-enterovirus 71 (EV71) activity in vitro o...

A concise synthetic route to rhamnan oligosaccharides with alternating α-(1→2)/(1→3)-linkages and repeating α-(1→3)-linkages is reported. This synthesis was achieved by iterative α-glycosylation using disaccharide building blocks and through orthogonal coupling between thioglycosides of L-...

A method is described for the synthesis of hydrochlorides of some type 8 title compounds in which the nucleophilicity of N-2 is reduced or completely lost so as to prevent ring contraction reactions and, as a result, making these compounds comparatively stable.

Methyl jasmonate (MeJA) was applied in a vineyard on leaves and grape clusters of cv Sangiovese to test its ability to stimulate the production of aromas and identify the main genes involved in the biosynthetic pathways switched on by the elicitor.MeJA application led to a delay in grape technol...

A series of β-chloroethylamines, structural hybrids of WB 4101, a competitive α1-adrenoreceptor antagonist, and phenoxybenzamine, an irreversible α-adrenoreceptor antagonist, has been synthesized and tested in isolated rat vas deferens α-adrenoreceptors. Although, for all compounds, apparent...

Optimization of AZD6482 (2), the first antiplatelet PI3Kβ inhibitor evaluated in man, focused on improving the pharmacokinetic profile to a level compatible with once daily oral dosing as well as achieving adequate selectivity towards PI3Kα to minimize the risk for insulin resistance. Structur...

Three complexes containing the novel, sterically hindered ligand 6-(methylpyridin-2-yl)acetate (PICAC) have been synthesized and characterized: [Pt(NH3)2(PICAC-N,O)]NO3 (1), [Pt(en)(PICAC-N,O)]NO3 (2), and [Pd(en)(PICAC-N,O)]NO3 (3) (en = ethane-1,2-diamine). The crystal structures of 2 and 3 ha...

One previously known and three novel quinolinyl phosphanes were synthesized by either a reaction between a lithiated diphenylphosphane and the appropriate chloroquinoline or by a reaction between a lithiated haloquinoline and an arylchlorophosphane. The reaction of the quinolinyl phenylphosphane...

Metallodrugs offer potential for unique mechanism of drug action based on the choice of the metal, its oxidation state, the types and number of coordinated ligands and the coordination geometry. This review illustrates notable recent progress in the field of medicinal bioinorganic chemistry as m...

This article provides a comprehensive review of palladium compounds that have been evaluated for anticancer activity in vivo or in vitro from the era of discovery of cisplatin up to 2015. In total, 847 compounds have been discussed into three categories namely (1) potent palladium compounds, (2)...