Capillary electrophoresis (CE) is a powerful technique to determine (2,3-epoxypropyl)trimethylammonium chloride, (3-chloro-2-hydroxypropyl)trimethylammonium chloride and their hydrolysis product (2,3-dihydroxypropyl)trimethylammonium chloride in complex matrices. The separation was performed in ...

We report herein the synthesis of a new hydrophilic and non-ionic anthracene derivative, the N,N′-di-(2,3-dihydroxypropyl)-9,10-anthracenedipropanamide. The evaluation of this compound as chemical trap of singlet molecular oxygen by using labeling experiments and HPLC–MS analysis showed that i...

Annonaceous acetogenins (AAGs) are environmental neurotoxins from the fruit pulp of several Annonaceae species, whose consumption was linked to the occurrence of sporadic atypical Parkinsonism with dementia. The quantification of the prototypical AAG annonacin in Rat brain homogenates was perfor...

Ethnopharmacological relevanceTamoxifen resistance is common in estrogen receptor-α (ERα)-positive breast cancers. Pawpaw and soursop are anticancer annonaceous plants in complementary medicine. Thus, we studied the effects of annonacin, an annonaceous acetogenin, in breast cancer cells.

Annonacin is an environmental neurotoxin identified in the pulp of several fruits of the Annonaceae family (for example in Annona muricata, Asimina triloba), whose consumption was linked with the occurrence of sporadic atypical Parkinsonism with dementia. Pharmacokinetic parameters of this molec...

IntroductionThe acetogenin, annonacin, from the tropical annonaceous plant Annona muricata, is a lipophilic, mitochondrial complex I inhibitor reported to be more toxic than rotenone to mesencephalic neurons. The temperate annonaceous plant Asimina triloba (pawpaw) is native to the Eastern Unite...

The Annonaceous acetogenin annonacin is an environmental neurotoxin identified in the pulp of several fruits of the Annonaceae family, whose consumption was linked to the occurrence of sporadic atypical Parkinsonism with dementia. A method for its quantification in Rat brain homogenates by UPLC-...

Novel ω-aminoacyl and -alkyl derivatives of 7-chloroquinolin-4-amine were prepared and their structures confirmed by NMR spectroscopy. Their antiprotozoal activities were examined in vitro against the sensitive NF54 strain as well as against the multiresistant K1 strain of Plasmodium falciparum...

Among new condensed quinolines and quinazolines the design of which were inspired by anti-cancer DNA-binding alkaloids such as camptothecin and batracyclin, DNA binding tests identify the 8-methoxy-7-piperazinylpropoxyindeno[1,2-b]quinolin-11-one tetracyclic system as a new motif for DNA recogni...

A new titanium nanomaterial based sulfonic acid catalyst was prepared and exhibited efficient catalytic activity for the synthesis of (E)-3-(2-(4-ethylpiperazin-1-yl)quinolin-3-yl)-1phenylprop-2-en-1-one derivatives under solvent free conditions. Briefly the catalyst was synthesized by refluxing...

ObjectiveTo compare medroxyprogesterone acetate (MPA) concentrations between HIV-infected women on antiretroviral therapy (ART) and HIV-negative women initiating depot medroxyprogesterone (DMPA) injectable.

BackgroundT helper 17 (Th17) cells, which are differentiated from CD4+ T cells, drive inflammation, leading to autoimmune diseases such as psoriasis, rheumatoid arthritis, and inflammatory bowel disease. Therefore, inhibiting Th17 polarization could be a therapeutic target for inflammatory diseases.

BackgroundUlipristal acetate (UPA) 30 mg (ella®, HRA-PHARMA, Paris, France) acts as an emergency contraceptive (EC) by delaying ovulation. Because it is a selective progesterone receptor modulator (SPRM), an additional effect on interfering with implantation has been suggested.

The aminolysis of ethyl acetate was promoted significantly via continuous reaction in a tubular reactor. N-propylacetamide was thus synthesized without presence of solvent and catalyst. The optimum conditions were obtained as follows: the reaction temperature is 218 °C, the reaction pressure is...

Herein, octaphenyl-polyhedral oligomeric silsesquioxane (OP-POSS)/polydimethylsiloxane (PDMS) hybrid membranes were prepared for the recovery of n-butyl acetate and ethyl acetate via pervaporation. The affinity of PDMS/OP-POSS membranes for n-butyl acetate and ethyl acetate 1 solvents was determ...

Publisher SummaryThis chapter discusses the various nerve and chemical-warfare agents. The offensive use of chemical agents continues to grow in some nations and terrorist organizations. Chemical agents can be dispersed over large areas or can penetrate structures, kill or sicken entire populati...

Publisher SummaryAdditives play an important role in the proliferation of plastics. Dispersants and coupling agents are also additives which, even when used in low concentrations, can have a profound effect on the performance and viability of plastic materials in diverse applications from packag...

Chromium (III) fumarato coordination compound (Volan 82) has proved to be a very successful bonding agent for the adhesion between metal and low density polyethylene. When an aluminum foil was treated with Volan 82 and laminated with low density polyethylene by extrusion coating, the composite f...

Additives are crucial to the successful application and proliferation of plastics. Small amounts of the appropriate additive can make the difference between a useless material and one with excellent mechanical properties and durability. Antioxidants and other stabilizers are used in parts per mi...

Greenhouse and laboratory experiments were conducted to determine the effect of imazapic on the herbicidal activity of clethodim on goosegrass. Imazapic did not affect absorption of [14C]clethodim by goosegrass. Averaged across the two treatments of clethodim alone and clethodim plus imazapic, a...