Indole derivatives derived from the secondary metabolites of marine organisms possess the excellent antifouling property to inhibit the biofouling. These compounds and their analogues are simple in structure and have been proven to have low toxicity and bioaccumulation. Therefore, the active ind...

A novel series of 3-((2-chloroquinolin-3-yl)methylene)indolin-2-ones were synthesized, using the ‘molecular hybridization approach’ and evaluated for anticancer efficacy. Eleven 3-((2-chloroquinolin-3-yl)methylene)indolin-2-ones (LM01 to LM11) were synthesized and evaluated for in vitro cytoto...

Lysine-specific demethylase 1 (LSD1), demethylase against mono- and di - methylated histone3 lysine 4, has emerged as a promising target in oncology. More specifically, it has been demonstrated as a key promoter in acute myeloid leukemia (AML), and several LSD1 inhibitors have already entered in...

Stimulated macrophages produce nitric oxide (NO) via inducible nitric oxide synthase (iNOS) using molecular O2, L-arginine, and NADPH. Exposure of macrophages to hypoxia decreases NO production within seconds, suggesting substrate limitation as the mechanism. Conflicting data exist regarding the...

Sea anemone toxins are predominantly peptide and proteins that act mainly on sodium and potassium channels, as well as in a variety of target cells causing lysis. Over recent years, the number of sea anemone peptide toxins as well as cytolytic pore-forming proteins and phospholipase A2 sequences...

The amino acid sequence of the sodium channel toxin RpIII from the sea anemone Radianthus paumotensis has been determined. The protein is homologous with five analogous toxins from three anemone species and is most similar to a less toxic protein, RpII, from the same organism. Twelve residues ar...

The experimental FT-IR (4000–400 cm−1) and Laser-Raman spectra (4000–100 cm−1) of ethyl (2E)-2-cyano-3-(4-methoxyphenyl)-acrylate in solid phase have been recorded. Its theoretical vibrational frequencies, IR intensities, Raman activities and optimized geometric parameters (bond lengths and bo...

Some fundamental properties of the 1,3-bis (4-methoxyphenyl) prop-2-en-1-one, as functional monomer, are measured as well as calculated. The combined results are used for modeling and predicting monomer structure–property relationships. Thus, theoretical calculations based on Density Functional...

Anthraquinone derivatives are most important class of a system that absorb in the visible region. In this work, the vibrational spectral analysis was carried out using FT-IR and FT-Raman spectroscopy for 2,4-bis(2-methoxyphenyl)-1-phenylanthracene-9,10-dione. Theoretical calculations were perfor...

The solid state structures of 3(5)-(4-methoxyphenyl)pyrazole and its coordination compounds with a series of two valent transition metals have been investigated. Since pyrazoles provide not only a nitrogen donor site for the coordination to metal ions, but also an additional N–H function, they ...

Upon UV-irradiation in methanol, bis(methoxyphenyl) methylphosphonates underwent an intramolecular coupling of two methoxyphenyl groups to give dimethoxybiphenyls and dimethoxy-9,10-dioxaanthracenes. The reactivities and fluorescence spectra of the phosphonates were sensitive to the position of ...

Dehydrogenation of 9,10-bis(4,5-diphenyl)-imidazol-2-yl)-anthracene furnishes the title compound. 1,4-Bis- [4,5-bis(p-methoxyphenyl-imidazol-2-ylidene)]-1,4-cyclohexadiene doesn't show any thermochromism.

1,8-Bis(dimethylamino)-2-(4-methoxyphenyl)naphthalene (1) was synthesized for use as an η6-coordinating ligand with a chargeable tag for ESI-MS analysis. The pKa of the proton sponge moiety was essentially unaffected by addition of the anisole group (pKa = 18.2 ± 0.7 at 297 K in CD3CN). Cr(η6...

1,1-bis(4-Methoxyphenyl)-2-phenylalkenes (1a–9a) and 1,1,2-tris(4-methoxyphenyl)alkenes (1b–9b) with various C2-substituents (H (1a, 1b), methyl (2a, 2b), ethyl (3a, 3b), propyl (4a, 4b), butyl (5a, 5b), 2-cyanoethyl (6a, 6b), 3-cyanopropyl (7a, 7b), 3-aminopropyl (8a, 8b), 3-carboxypropyl (9a...

N,N-Dimethylcarbamoyl(trimethyl)silane reacted with N-Boc-imines in anhydrous benzene under catalysts-free conditions to afford N-Boc-protected α-amino amides in good yields (72–89%). The electronic property and the steric hindrance of substituent on the N-Boc-imines affected the reaction.

The first ESR spectral data for the title amidyl radicals are reported. They are consistent with π electronic ground states.

Kinetics for the hydrolysis of the chromogenic active site titrantNα-(N,N-dimethylcarbamoyl)-α-azalysinep-nitrophenyl ester (Dmc-azaLys-ONp) catalyzed by bovine β-trypsin, bovine α-thrombin, human α-thrombin, human Lys77-plasmin, human urinary kallikrein, theMr33,000 andMr54,000 species of ...

Background and AimsIn the present study, a series of ureas and sulfamides derived from 1-aminotetralins were synthesized. For this purpose, urea and sulfamide analogues were synthesized from the reactions of substituted 1-aminotetralins with N,N-dimethylcarbamoyl chloride and N,N-dimethylsulfamo...

Kinetics of bovine β-trypsin (trypsin) with the Nα-(N,N-dimethylcarbamoyl)-α-aza-lysine p-nitrophenyl ester (Dmc-azaLys-ONp) was obtained at pH 6.2 and 21.0°C. Dmc-azaLys-ONp shows the characteristics of an optimal active site titrant in that it (i) gives titrations in a short time, (ii) is ...

Solvation and association interactions in solutions of LiBF4/DMCC (DMCC for N,N-dimethylcarbamoyl chloride) and LiBF4/DMCC–DME (DME for 1,2-dimethoxyethane) have been studied as a function of concentration of lithium tetrafluoroborate by infrared and Raman spectroscopy. Strong interactions betw...