Method validation presents a detailed investigation of analytical method and provision of the evidence that the method, when correctly applied, produces results that fit to the purpose. In order to achieve the method validation scope efficiently, experimental design presents a very useful tool. ...

Dynemicin A has the ability to undergo the Bergman cyclization, forming a para-benzyne moiety with the ability to induce DNA strand scission. This property of dynemicin A makes it a promising anti-tumor agent. Past research has shown conclusively that dynemicin A binds to and abstracts a hydroge...

IntroductionLiver regeneration is a normal response to liver injury. The aim of this study was to determine the molecular basis of liver regeneration, through an integrative analysis of high-throughput gene expression datasets.

SummaryTwo major functions of the epigenome are to regulate gene expression and to suppress transposons. It is unclear how these functions are balanced during physiological challenges requiring tissue regeneration, where exquisite coordination of gene expression is essential. Transcriptomic anal...

A Headspace-Solid Phase Microextraction–Gas Chromatography–Mass Spectrometry (HS-SPME–GC–MS) method was developed and validated for the simultaneous determination of furan, 2-methylfuran, 2-ethylfuran, 2-butylfuran, 2-pentylfuran, 2-acetylfuran, furfural and furfuryl alcohol in jarred baby f...

A furan resin, synthesized from furfural and phenol, was previously proposed as a less environmental impact alternative to traditional phenolics’ coatings to protect aluminum. In this work, the furan resin was modified with 10 and 20%wt of prepared cellulose nanocrystals (CNC), a biobased nanor...

The aim of the present study was to develop an eco-friendly biological process for the production of 2,5-furan dicarboxylic acid (FDCA) from 5-hydroxy methylfurfuraldehyde (HMF) using microorganisms. Microorganisms were isolated from the soil samples and evaluated for its biotransformation effic...

Homogeneous and monodispersed furan-functionalised melamine-formaldehyde particles were produced. As a precursor, 2-chloro-1,3,5-triazine-2,4-diamine (Mel) was selectively substituted with 2-aminomethyl furan (Fu) units in a convenient one step reaction. The pure reaction product Fu-Mel, which w...

Many skin disorders and diseases are related to tyrosinase activity, in particular, due to the vital role played by this enzyme in the melanogenic process. Although numerous natural and synthetic tyrosinase inhibitors have been published, substantial efforts have been made to understand the infl...

Oxidative cleavage (OsO4/NaIO4) of a monoprotected dihydroxy sulfinyl diene affords a lactol, readily transformed into a sulfinyl pyranose. Alternatively, base promoted intramolecular cyclization of a lactol derived carbamate to a bicyclic oxazolidinone followed by simple transformations leads t...

Furan is a colorless toxic organic compound that is produced during thermal degradation of natural food constituents, and is present in various processed foods such as coffee and processed baby foods. The present study investigated the endocrine disrupting potential of furan in Sprague Dawley ma...

Coffee has been determined as the dominant source of furan within an adult’s diet. This study investigates the influence of coffee condiment use and stirring on the retention of furan. Three condiment lipid compositions were investigated, 0%, 3.5% and 35%, and kept at either 4 °C, 20 °C or 70...

In this work, we obtained the vibrational spectra of 1-(2,5-dimethyl-furan-3-yl)-ethanone (1DF3E) by using Density functional theory (DFT) calculations. Normal coordinate analysis also carried out to the titled compound in order to support the vibrational spectra of (1DF3E). After that, the resu...

The enantioselective separation of substituted 3-phenoxy-1,2-propanediols (PPDs) and aziridinecarboxylic acid derivatives (ACAs) on Chiralpak AD, an amylose-based chiral stationary phase, was investigated. All solutes could be separated using hexane-alcohol mobile phases. The retention times for...

Enantiomeric separations of four 2-substituted propionic acid drugs and two related acids have been studied using normal phase liquid chromatography with amylose (tris 3,5-dimethylphenylcarbamate) coated on silica as support (Chiralpak AD). At standard conditions (i.e. flow-rate, 1.0 ml/min; col...

The zero length column (ZLC) technique for measurement of pore diffusivity in chiral adsorbent CHIRALPAK AD with particle size 20 and 50 μm at temperature of 25 °C was used. Due to limited sensitivity of the detectors and higher liquid density, the experimental conditions under which the relia...

This paper reports a comparison study of the difference between Chiralpak AD-H and AD columns in enantioseparation of dihydropyrimidinone (DHP) acid and its methyl ester under normal phase LC conditions. Unlike those of the AD phase, the van’t Hoff plots of retention factors for DHP acid on the...

The chiral separation by packed column supercritical fluid chromatography (pSFC) has pronounced advantages due to its enhanced efficiency and reduced solvent consumption. Seven racemic γ-lactones (γ-C6–γ-C12) which are important flavor and fragrance substances were successfully resolved in l...

Determination of competitive adsorption equilibrium model with continuous temperature dependent parameters is important for the design and optimization of a chromatographic separation process operated under non-isothermal conditions. In this study, linear pulse experiments were first carried to ...

Streptococcus pyogenes (group A Streptococcus [GAS]) is the leading cause of bacterial pharyngitis. To perform a rapid diagnosis of GAS pharyngitis, rapid antigen detection tests (RADTs) have been developed. In this study, we evaluated and compared the sensitivity and specificity of 5 RADTs (bio...