Malaria and schistosomiasis are two of the most socioeconomically devastating parasitic diseases in tropical and subtropical countries. Since current chemotherapeutic options are limited and defective, there is an urgent need to develop novel antiplasmodials and antischistosomals. Hemozoin is a ...

Targeted nanomedicine for cancer therapy has gained widespread popularity and is being extensively explored. Porphyrins have intrinsic tumor localizing ability and have been studied for photodynamic therapy. However, they have not been used as cancer targeting agents for nanomedicines. In this s...

Hematin plays a crucial role in various physiological functions, and the determination of hematin in complex biological matrixes is a significant but difficult issue. Considering the unique photophysical/photochemical properties of carbon quantum dots (CQDs) prepared with p-aminobenzoic acid (PA...

A mathematical description of the kinetics of the hematin catalysed decolourization reaction of Orange II alkaline solutions was constructed and validated under the assumption that hematin mimics the action of peroxidases. The clean oxidant H2O2 was applied, however, hematin dismutated it, as ca...

Malaria is an infectious disease caused by Plasmodium type parasites transmitted by the bites of infected female anopheles mosquitoes. The malaria parasite multiplies in red blood cells where it degrades hemoglobin. This degradation of hemoglobin proteins releases hematin, an iron-containing por...

The effect of pressure on the Raman and fluorescence spectra of hematin anhydride (β-hematin) is reported. In a diamond-anvil cell, DAC, with applied pressures up to 41 kbar, the Raman spectrum undergoes a series of intensity enhancements and increases in energy for many of the Raman-active ban...

Hematin is an oxidized form of heme, and the abnormal levels of hematin in the human body can lead to various inflammatory lesions. Hence, there is still a need to establish a rapid, sensitive and efficient method for hematin detection. Herein, the green fluorescent carbon quantum dots (CQDs) ar...

Ferriprotoporphyrin IX (FPIX) forms a coordination complex with chloroquine, an anti-malarial drug. The FPIX-chloroquine complex strongly promotes the peroxidative cleavage of phospholipid membrane. Iron in the complex is essential for the complex to induce lipid peroxidation. In this paper a mo...

Hemin has been reported to be an effective electrocatalyst for mediating the oxygen reduction reaction. In this work, the stability of hemin/C is extensively investigated in both acid and alkaline media by the electrochemical methods. It is found that the pristine hemin/C yields significant chan...

The effect of a ferriprotoporphyrin IX -chloroquine complex on phospholipid membranes was investigated on the basis of iron-induced lipid peroxidation using microsomal phospholipid liposomes. The ferriprotoporphyrin IX -chloroquine complex remarkably promoted peroxidative cleavage of unsaturated...

The interaction between aniline and ferriprotoporphyrin IX in alkaline solution has been investigated using pyridine and the N-methyl pyridinium ion as site-specific inhibitors of oxygen activation. Pyridine inhibits oxygen activation in a noncompetitive manner with respect to aniline (K1 = 1.24...

In order to explore the interaction of mefloquine with hemin against adult Schistosoma japonicum in vitro, the 50% and 95% lethal concentration (LC50 and LC95) of mefloquine and hemin against schistosomes, some factors, such as other iron providing agents, iron chelaters, zinc protoporphyrin-IX,...

In recent years, the carbohydrate polymers incorporated composite materials have shown significant interest in the bioanalytical chemistry due to their enhanced catalytic performances of various enzymes or mimics. This paper reports the fabrication of novel H2O2 biosensor using a hemin immobiliz...

An ionic liquids-based ultrasonic-assisted extraction (ILUAE) method was successfully developed for extracting eleutheroside B and E from Radix Acanthopanax senticosus. Thirteen 1-alkyl-3-methylimidazolium ionic liquids with different cations and anions were investigated and 1-butyl-3-methylimid...

Eleutheroside B and Eleutheroside E, two kinds of the major bioactive saponins of Eleutherococcus senticosus, play a pivotal role in biologic activity. In this study, a specific and sensitive high performance liquid chromatography–electrospray ionization-tandem mass spectrometry method (HPLC–M...

Human body is constantly generating free radicals, which causes oxidative stress. Despite naturally occurring antioxidant systems in human body, free radicals cause lipid, proteins and DNA oxidation. New antioxidants are still urgent as well as their mechanisms of action should be explained. In ...

Intramolecular hydroxylamine-alkyne cyclisation of the hydroxylamines 8 and 9 afforded six-membered cyclic nitrones which without isolation underwent a tandem intramolecular dipolar cycloaddition to produce the tricyclic isoxazolidines 6 and 7 respectively. These were converted in two steps into...

Spectral and photophysical properties of 4H-1-benzopyran-4-thione (BFT) in aqueous solutions of β-cyclodextrin (β-CD) and in some solvents have been investigated by stationary methods. Both fluorescence and phosphorescence of BPT are observable at room temperature. Results indicate the formati...

2-Styryl- and 2-furyl-3-benzyloxy-4-oxo-4H-1-benzopyran on photolysis in benzene and MeOH, respectively, yield 2,3-pyranobenzopyrones via H-abstraction.

SummaryA series of 2-[2-alkyl-1H-benzimidazol-5(6)-yl]-4H-1-benzopyran-4-one analogues 7a-7e was synthesized by the reaction with 3′,4′-diaminoflavone and aliphatic carboxylic acids. 3′,4′-Diaminoflavone 6 was prepared via the reduction of 2-(4-amino-3-nitrophenyl)-4H-1-benzopyran-4-one 5a. ...