The Allam Cycle is a novel oxy-combustion gas turbine power cycle with a reported net cycle efficiency of 58–60% LHV and near-zero operating emissions. An Allam Cycle process model is developed displaying a net cycle thermal efficiency (LHV) of 58.0%, a higher value than previously reported in ...

The increasing decarbonisation of the power and heat sectors in Great Britain poses numerous uncertainties about the future of the gas network. An optimisation model was developed for investigating the operation of future low carbon electricity, gas and heat supply systems. The model was employe...

Around 80% of domestic heat demand in Great Britain (GB) is supplied by natural gas, but continuing to heat dwellings in this way is unlikely to be compatible with national emission reduction targets. Electrical heating using heat pumps is expected to play a significant role in future space heat...

The effects of candoxatrilat (cis-4-[[2-carboxy-3-(2-methoxyethoxy)propyl]-1-cyclo-pentanecarbonylamino]-1-cyclohexane carboxylic acid) and the ring-deleted atrial natriuretic factor (ANF) analogue C-ANF4–23 (des[Gln18, Ser19, Gly20, Leu21, Gly22]ANF4–23−-NH2) on the clearance of (3-[125I]iodo...

Objectives.Our primary objective was to compare the effects of three different doses of candoxatrilat with the effects of placebo on urinary volume in patients with moderately severe heart failure. The effects of candoxatrilat on urinary composition, neuroendocrine indexes and renal hemodynamic ...

We studied whether enprostil, a synthetic prostaglandin E2 derivative, might inhibit gastrin release and the trophic effects on gastric oxyntic mucosa induced by prolonged treatment with an inhibitor of hydrogen-potassium-stimulated adenosine triphosphatase, the substituted benzimidazole BY 831-...

Bolesatine is a toxic monomeric glycoprotein of Mr 63 000 isolated from the mushroom Boletus satanas Lenz. Its N-terminal amino acid sequence was established: NH2-Thr-Trp-Arg-Ille-Tyr-Leu-Asn-Asn-Gln-Thr-Val-Lys-Leu-Ala-Leu-Leu-Leu-Pro-Asn-Gly… It inhibits protein synthesis in isolated rat mito...

1.1. A lectin has been purified from the mushroom Boletus satanas Lenz.2.2. The protein, called bolesatine, is mitogenic for human T lymphocytes in a dose- and time-dependent manner.3.3. Optimal mitogenic doses induce the release of interleukin-1α and interleukin-2 from mononuclear cell cultures.

Protein, DNA, and RNA syntheses were assayed in Madin Darby canine kidney cells (MDCK) treated by bolesatine, a toxic glycoprotein from the mushroom Boletus satanas (single chain, Mr 63 000 ± 3000, pI 8.3 ± 0.1, disulphide intrachain bridge) previously shown to be an inhibitor of in vitro prot...

Protein synthesis was assayed in liver and kidney of mice treated with bolesatine, a toxic glycoprotein from the mushroom Boletus satanas (Lenz) which was previously shown to be an inhibitor of protein synthesis by cell-free systems in vitro and by cultured cell-lines. Protein synthesis in vivo ...

Bolesatine, a toxic protein isolated from Boletus satanas Lenz inhibits in vitro protein synthesis in a concentration-dependent manner in a cell line from a radiation-induced thymic lymphosarcoma (SP2/O) with a 50% inhibitory concentration (IC50) of 9.5 nM (0.6 μg/ml). In vivo, an i.p. single i...

Bolesatine is a potent cytotoxic glycoprotein purified from Boletus satanas Lenz, which has previously been shown to be an inhibitor of protein synthesis in several in vitro systems and in vivo. For a better understanding of its mechanism of action on protein synthesis at the ribosomal level, ra...

Bolesatine is a glycoprotein purifed to homogeneity from Boletus satanas Lenz, a toxic mushroom which causes serious gastroenteritis. This lectin possesses a mitogenic activity on human lymphocytes at very low concentrations, whereas higher concentrations inhibits protein synthesis in vitro in s...

1-[N-Phenyl(aminomethyl)]silatrane PhNHCH2Si(OCH2CH2)3N was prepared and characterized by multinuclear NMR spectroscopy and single-crystal X-ray diffraction analysis. Its reactivity with CCl4, AgNO3, CuCl2 and α-,β-unsaturated cyclic ketones was investigated.

Dolastatin 15, a seven-subunit depsipeptide derived from Dolabella auricularia, is a potent antimitotic agent structurally related to the antitubulin agent dolastatin 10, a five-subunit peptide obtained from the same organism. We have compared dolastatin 15 with dolastatin 10 for its effects on ...

A twenty year pursuit of the cell growth inhibitory and antineoplastic constituents of the Western Indian Ocean (Mauritius) sea hare Dolabella auricularia has resulted in the discovery of fifteen structurally unique peptide, cyclopeptide, depsipeptide, and cyclodepsipeptide type-substances desig...

A segment synthetic strategy was utilized for obtaining the Dolabella auricularia (Indian Ocean sea hare) depsipeptide dolastatin 15. Reaction of protected (S)-Hiva-(S)-Phe 2c with isopropenyl chloroformate followed by Meldrum's ester, cyclization (2c → 3a) of the product in toluene and fi...

Dolastatin 15 1(4S,7S) is a potent cytostatic depsipeptide of marine origin. Analysis of the effects of the stereochemistry in the non-peptide moiety on activity revealed that chirality inversion in the aromatic terminal region preserves the antiproliferative activity.

Efficient synthesis of dolastatin 15 (1) was accomplished following a convergent strategy. The pyrrolidinone cycle of 5 was obtained by thermic cyclization of the corresponding Meldrum's adduct 4. The methylation of the enol function was performed under Mitsunobu conditions. On the other ha...

Eight peptoids have been synthesized as peptidomimetics of the cytostatic Dolastatin 15, a depsipeptide isolated from the Indian sea hare Dolabella auricularia. The compounds have been tested against several human cancer cell lines and did not show any cytostatic properties.