Monomethoxypoly(ethylene glycol) cholesteryl carbonates (M-PEG-Chol) with polymer chain molecular weights of 1000 (M-PEG1000-Chol) and 2000 (M-PEG2000-Chol) have been newly synthesized and characterized. Their aggregation behavior in mixture with diglycerol hexadecyl ether (C16G2) and cholestero...

The importance of BCL-2 family proteins in the control of cell death has been clearly established. One of the key members of this family, BAX, has soluble, membrane-bound, and membrane-integrated forms that are central to the regulation of apoptosis. Using purified monomeric human BAX, defined l...

Extrinsically conjugated fluorescent diphenylpolyene cholesterol derivatives are synthesized and spectroscopic investigations in homogeneous and aqueous micellar solutions are described. The emission of these cholesterol conjugates reveals characteristic intra-molecular charge transfer (ICT) beh...

Therapeutic chaperone effect of a valienamine derivative N-octyl 4-epi-β-valienamine (NOEV) was studied in GM1-gangliosidosis model mice. Phamacokinetic analysis revealed rapid intestinal absorption and renal excretion after oral administration. Intracellular accumulation was not observed after...

A systematic study with phase 1 and phase 2 metabolites of cholesterol and vitamin D was conducted to determine whether their biological activity is mediated by the vitamin D receptor (VDR). The investigation necessitated the development of novel synthetic routes for lithocholic acid (LCA) glucu...

This study examined the effect of cholesterol esterase (CE) on the degradation of commercial poly(ether urethane) (PEU) and poly(carbonate urethane) (PCU). Unstrained PEU and PCU films were incubated in 400 U/mL CE solution or a buffer control for 36 days. The study used a concentration of chole...

Amphotericin B (AmB) is an antifungal drug with a broad spectrum of action. It has few resistance reports, and it is widely used for treating invasive fungal infections. However, it has many drawbacks related to its administration and undesired side effects, such as nephrotoxicity. The use of po...

Retinal disorders account for a large proportion of ocular disorders that can lead to visual impairment or blindness, and yet our limited knowledge in the pathogenesis and choice of appropriate animal models for new treatment modalities may contribute to ineffective therapies. Although genetic i...

Background: Iodate is a strong oxidant, and some animal studies indicate that iodate intake may cause adverse effects. A key focus of the safety assessment of potassium iodate as a salt additive is determining whether iodate is safely reduced to iodide in food. Objective: To study the reduction ...

Treatment of 2-O-benzoyl (1) and 2-O-acetyl (5) derivatives of benzyl 4,6-O-benzylidene-3-O-(2,3,4-tri-O-acetyl-α-l-rhamnopyranosyl)-β-d-galactopyranoside under Zemplén conditions (catalytic amount of sodium methoxide in methanol) gave partially deacylated disaccharides in which the 2-O-acyl ...

New antibacterial composites were synthesized by modification and functionalization of montmorillonite (MMT). The antibacterial composites were synthesized by the reaction of MMT clay with the quaternary salt of p-N,N-dimethylamino benzaldehyde which produced modified functionalized montmorillon...

MNDO and AM1 theories on PCMODEL-optimized geometries are used to calculate the pKa-values of some 190 phenols and aromatic and aliphatic carboxylic acids. Heats of formation and the anion HOMO energies satisfactorily correlate with experimental (condensed-phase) acidity (correlation coefficient...

The occurrence of xanthomegnin, viomellein and vioxanthin in commercial samples of wheat and oil seed rape, and of xanthomegnin and vioxanthin in barley, is reported for the first time. Analytical methodology for detection and confirmation of these compounds is described.

Ménière’s disease (MD) is a progressive disease of the inner ear characterized by recurring attacks of disabling vertigo, hearing loss and tinnitus. Patients who do not respond to vestibular sedatives or steroids may require an intratympanic application of aminoglycoside antibiotics, which de...

In the search for molecules possessing antibiotic or antiviral properties and ribonuclease like activity, that is, able to induce the cleavage of bacterial or viral RNA targets, we report a new route for preparing selectively neamine derivatives modified at their 4′- and/or 5-hydroxyl functions...

Three types of neamine-β-carboline conjugates were synthesized in good yields by the coupling of neamine and β-carboline-3-carboxylic acids using aliphatic diamine as a linker. The binding properties of these conjugates to 16S rRNA and 18S rRNA were evaluated by surface plasmon resonance (SPR)...

Thiobenzyl benzyloxycarbonyl-l-lysinate (Z-Lys-SBzl), a substrate for trypsin-likeproteases, was synthesized. In the presence of 5,5′-dithiobis(2-nitrobenzoic acid) the hydrolysis of the thiol ester by trypsin-like enzymes provides a continuous colorimetric assay with a sensitivity comparable t...

Photolysis of a 1:2 mixture of M(CO)6 (M=Cr, Mo) and diphenylvinylphosphine (DPVP) in tetrahydrofuran produces (DPVP)M(CO)5, cis- and trans- (DPVP)2M(CO)4, (dppe)M(CO)4 (dppe=1,2-bis (diphenylphosphino)ethane, and fac- (dppe) (DPVP)Mo (CO)3. The complexes have been characterized by elemental ana...

The electrochemical analysis, theoretical examination, as well as the first X-ray photoelectron spectroscopic (XPS) study on molybdenum(0) Fischer carbene complexes are presented. The intramolecular communication between the carbene ligand, molybdenum metal centre, and the ancillary ligands is i...

The structure of (diphos)Mo(CO)4 (diphos=1,2- bis(diphenylphosphino)ethane) has been determined by single crystal X-ray crystallography. The crystals are orthorhombic with a=22.600(8), b=16.799(4) and c=14.587(4) Å, space group Pbca, Dcalc.=1.45 g cm−3 and Z=8. The structure was solved by the Pa...