In this work, the CO2 equilibrium solubility in 1-dimethylamino-2-propanol (1DMA2P) solution was determined as a function of 1DMA2P concentration (over the range of 1–5 M), temperature (in the range of 298–333 K), and CO2 partial pressure (in the range of 8–101 kPa), and the data used to fit ...

Mescaline (3,4,5-trimethoxyphenethylamine) and N-succinylmescaline were coupled to human serum albumin with carbodiimide. DOM (2,5-dimethoxy-4-methylphenylisopropylamine) was linked to human serum albumin by reaction with glutaraldehyde. These conjugates were used for immunization of rabbits. De...

Stable new N-alkyliminodialanes [(CH3)2N(CH2)3N(AlH2)2]2·THF and [(Ch3)2NCH2(CH3)CHN(AlH2)2]2·THF have been prepared from AlH3·THF (or NaAlH4) and the corresponding amine(or hydrochloride derivative). These products have been characterized principally by mass spectrometry.

Several 11-ethyl-2,3-dimethoxy-8,9-methylenedioxy-11H-isoquino[4,3-c]cinnolin-12-ones with varied functionality on the ethyl substituent have exhibited potent topoisomerase I (TOP1) targeting activity and antitumor activity. The influence of various polar substituents at the 2-position of the 11...

3-Dimethylamino-n-propylamine, 2-dimethylamino-isopropylamine and 3-methoxy-n-propylamine have been used to synthesize poly(N-alkyliminoalanes) (PIA) by different routes. These amines yielded PIA with open cage structures, in some cases even under the rather drastic conditions of direct synthesi...

Substitution reactions on 2′,3′,5′,6′-tetrachloro-4-dimethylamino-[1,4]bipyridinyl-1-ylium chloride with nitrogen nucleophiles such as n-propylamine, isopropylamine, glycine, morpholine, and piperidine were examined. Highly functionalized Cl2,Cl3,N4,Cl5,Cl6- and N2,Cl3,N4,Cl5,Cl6-substituted...

A procedure has been described for the preparation of N-methyl-1,3-dimethylbutylamine from methyl isobutyl ketone and methylamine. The method involves low pressure hydrogenation of ketimine in the presence of platinum catalyst.

1,3-dimethylbutylamine (DMBA), is a CNS stimulant, which has recently been identified in multiple dietary supplements and sometimes labeled as a natural constituent of Pouchung tea. DMBA is an homologue of 1,3-dimethylamylamine (DMAA) which the US Food and Drug Administration has attempted to re...

Mercury plays a critical role in serious health problems due to environmental or occupational exposures. Aquatic ecosystems are an essential component of the global biogeochemical cycle of mercury, as inorganic mercury can be converted to toxic methyl mercury in these environments and reemission...

Reference measurements for methyl mercury in four new type of environmental matrix-matching certified reference materials (CRMs) were performed and values of methyl mercury mass fractions were assigned. Hyphenated technique high-performance liquid chromatography (HPLC) and inductively coupled pl...

In the actual vinyl acetate production process, benzene is a very harmful by-product for the quality of the product. In this work, the experimental method and DFT method are combined to study how the by-product benzene is produced during the production of vinyl acetate by acetylene gas-phase. Th...

Densities, viscosities and speed of sound of binary liquid mixtures of vinyl acetate with butyl vinyl ether, diisopropyl ether, anisole, and dibutyl ether are presented over the complete concentration range at (303.15, 308.15 and 313.15) K and 0.1 MPa. Excess volume, deviations in viscosity, ise...

The removal of trace benzene from vinyl acetate with zeolitic imidazolate frameworks (ZIFs), a kind of metal-organic frameworks (MOFs) with formula unit M(IM)2 is studied. ZIF-2, ZIF-3, ZIF-6, ZIF-8, ZIF-10, and ZIF-68 are selected to study the adsorption of benzene and vinyl acetate. Density fu...

Vapour pressures for mixtures of cyclohexane + nitromethane, + nitroethane, + 1-nitropropane, and + 2-nitropropane at 318.15 K have been determined using a stepwise-dilution static vapour-pressure apparatus. Particular attention is paid to mixtures dilute in nitroalkane. Activity coefficients an...

Male Sprague-Dawley rats were exposed to vapors of 1-nitropropane (1-NP) and 2-nitropropane (2-NP) at air concentrations of 100 ppm for 7 hours per day on four consecutive days. Livers were analyzed for enzymatic activities after 1-, 2-, and 4-day inhalation periods. Liver microsomal cytochrome ...

Micronucleus tests were carried out in bone marrow of mice treated with 1-nitropropane, 2-nitropropane and cisplatin. For 1-nitropropane and 2-nitropropane the results were negative. With cisplatin a dose-dependent increase in the number of polychromatic erythrocytes with micronuclei was observe...

Three main primary fragmentation channels of molecular ion (m/z > 89) of 1-nitropropane induced by γ-hydrogen shift: (1) McLafferty rearrangement, (2) formation of nitric oxide and (3) detachment of hydroxyl induced by γ-hydrogen transfer were studied employing ab initio UMP2 level of theory. ...

A highly diastereoselective synthesis of heritol and heritonin by intramolecular cyclization on a preformed sensitive butenolide functionality is described.

Cu(OTf)2 catalyzed synthesis of propargylated 2,3-dihydroquinazolin-4(1H)-ones has been accomplished from 2-amino-N-propargyl benzamides and aromatic aldehydes under MW irradiation. Next, a series of novel glycosyl triazolyl methyl quinazolin-4(3H)-ones have been synthesized by CuAAC reaction of...

Based on the original spirodiketopiperazine design framework, further optimization of an orally available CCR5 antagonist was undertaken. Structural hybridization of the hydroxylated analog 4 derived from one of the oxidative metabolites and the new orally available non-hydroxylated benzoic acid...