The crystal structures of Salmonella typhimurium 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate kinase (HMPP kinase) and its complex with substrate HMP have been determined. HMPP kinase catalyzes two separate ATP-dependent phosphorylation reactions and is an essential enzyme in the thiamin...

The (2-amino-4-methylpyrimidine)-(pyridine-2,6-dicarboxylato)copper(II) monohydrate complex was synthesized and characterized by spectroscopic (IR, UV/Vis, EPR), thermal (TG/DTA) and electrochemical methods. X-ray structural analysis of the title complex revealed that the copper ion can be consi...

The overexpression, purification and characterization of 4-amino-5-hydroxymethyl-2-methylpyrimidine kinase (HMP kinase) and 4-amino-5-hydroxymethyl-2-methylpyrimidine monophosphate kinase (HMP-P kinase) are described. Surprisingly HMP-P kinase also shows HMP kinase activity. These enzymes are us...

Studies concentrating on hydrogen bonding interactions between 2-amino-4-methylpyrimidine (AMPY) with selected dicarboxylic acids have been investigated in the solid state. Two pyrimidinium-dicarboxylate organic salts with stoichiometry 1:1 [AMPY: maleic acid] and 2:1 [AMPY:d(+)-malic acid] have...

The solid phase FTIR and FT–Raman spectra of 2-amino-4-chloro-6-methylpyrimidine (2A4Cl6MP) have been recorded in the regions 400–4000 and 50–4000 cm−1, respectively. The spectra have been interpreted interms of fundamentals modes, combination and overtone bands. The structure of the molecule...

A new Cd(II) complex with the monodentate ligand 2-amino-4-methylpyrimidine, [Cd(NO3)2(C5N3H7)2(H2O)2], has been prepared and characterized by single crystal X-ray diffraction, elemental analysis, CP–MAS NMR and IR spectroscopy. The basic coordination patterns of the 2-amino-4-methylpyrimidine ...

The FTIR and FT-Raman spectra of 2-amino-4-methoxy-6-methylpyrimidine (AMMP) and 2-amino-5-bromo-6-methyl-4-pyrimidinol (ABMP) have been recorded in the region 4000–450 and 4000–100 cm−1, respectively. The optimized geometry, frequency and intensity of the vibrational bands of AMMP and ABMP we...

The chemical preparation, crystal structure, magnetic study and spectroscopic characterization of the new Cu(II) complex with the monodentate ligand 2-amino-4-methylpyrimidine [Cu2(CH3COO)4(C5N3H7)2] are reported. The copper atoms are surrounded by one nitrogen atom from one 2-amino-4-methylpyri...

The mixed oxides of CuOCuCr2O4 (CuCrO) with different Cu/Cr mole ratios were examined for synthesis of 2,6-dimethylpyrazine (2,6-DMP) by the utilization of aqueous glycerol in conjunction with 1,2-propanediamine (1,2-PDA). Influence of acid-base (both Bronsted and Lewis) sites on the product dis...

A continuous process for the synthesis of cis-2,6-dimethylpiperazine was described in this paper. The cyclization of N-β-hydroxypropyl-1,2-propanediamine proceeded effectively over a Cu-Cr-Fe/γ-Al2O3 catalyst in a fixed-bed reactor. Cu0 and Cu+ were believed to be the active sites of the catal...

The critical temperatures and pressures of caprolactam (CASRN 105-60-2), dimethyl sulfoxide (CASRN 67-68-5), 1,4-dimethylpiperazine (CASRN 106-58-1), and 2,6-dimethylpiperazine (CASRN 108-49-6) have been measured by the pulse-heating technique applicable to thermally unstable compounds. Experime...

The study of the liquid-liquid equilibrium (LLE) between 2,6-lutidine, 2,6-lutidine-N-oxide and water is important since it has the potential to influence the overall rate of the N-oxidation reaction involving these chemicals. The hydrogen peroxide, which is used as an oxidant to convert the lut...

Benzamides I, phenylalkanamides II and cinnamamides III are structurally related to the antiinflammatory N-(4,6-dimethylpyridin-2-yl)benzamide I. These were synthesized and the transformation of the 2-aminopyridine nucleus of benzamides I into a 2-imino-1,2-dihydropyridine structure (compounds I...

Two new isomeric forms of Cu(NCO)2(2,4-lutidine)2, a violet β and a blue γ, were prepared and examined by several physical methods. According to X-ray diffraction patterns the crystal structure of the β-isomer is very close to that of the known α-isomer, whereas the γ-isomer has a considera...

The infra-red spectra in the liquid and vapour phases and the Raman spectra in the liquid state at room temperature and in the solid state at −180°C have been measured for 2,6- and 2,4-lutidine. Complete assignments of the observed frequencies have been proposed.

The development of new potential anti-inflammatory compounds resulting from the incorporation of α-aminoacid residues into 6-amino-2,4-lutidine afforded (N-protected) aminoamides with interesting inhibitory activity. Out of 28 tested compounds, 10 (5a, 5b, 7d, 8a, 8b, 8d, 10a, 11b, 12a and 12b)...

The main purpose of this work is the determination of the excess heat of mixing HE for binary mixtures of 2,4-lutidine and C6 to C10n-alkanes at 298.15 K. Prigogine-Flory-Patterson theory and the extended real associated solutions (ERAS) method are applied to describe the excess heat of mixing o...

The Host compound 2,2ʹ bis(1-hydroxy-4,5-dihydro-2,3:6,7-dibenzocycloheptatrien-1-yl)-biphenyl, H1, has been employed to discriminate between all the pairs of lutidine isomers. The preference for guest enclathration follows the sequence 3,4-LUT>2,4-LUT≈3,5-LUT>2,5-LUT>2,3-LUT>2,6-LUT. This has ...

The infrared and Raman spectra of six new metal (II) 2,4-lutidine tetracyanonickelate complexes, M(L)2Ni(CN)4, [M = Mn, Cd, Fe, Co, Zn or Ni, L = 2,4-lutidine] have been studied. Their structure consists of polymeric layers of [M − Ni(CN)4]∞ with 2,4-lutidine molecules bound directly to the met...

The crystallisation of dichloro-bis(2,4-lutidine)-zinc from various solvents (e.g. ethanol, THF and 2,4-lutidine) has been investigated and two phases were isolated. The structures of both phases were determined by single crystal X-ray diffraction and both types of crystals were found to be comp...