Phynox is of high interest for technological applications due to its high corrosion resistance, mechanical properties and biocompatibility. In combination with these remarkable characteristics, some Phynox applications require specific surface properties that can be imparted with suitable surfac...

Novel hydrogels with phosphoric acid-bearing units suitable for agricultural applications have been obtained. Introducing phosphate moieties into acrylate-based hydrogels could result in better swelling properties, especially under acidic conditions as the dissociation constants of phosphoric ac...

In this study, a surface modification of poly(vinylidene fluoride) (PVDF) nanofibers by atom transfer radical polymerization (ATRP) was developed to form bis[2-(methacryloyloxy)ethyl] phosphate (BMEP) crosslinked polymer brushes grafted on nanofibers for application in rechargeable lithium batte...

Unblemished fully ripe fruit from five day-neutral strawberry cultivars were harvested on two separate dates and evaluated for ascorbic acid (AsA), fruit sugars, and phenolic composition. Individual phenolics were determined by HPLC, and total phenolics by Folin–Ciocalteu (F–C) and by a ‘new’...

The androgen receptor (AR) is a ligand-inducible transcription factor belonging to the nuclear receptor superfamily, and is a target molecule for development of drugs to treat prostate cancer. However, AR antagonists in clinical use, such as flutamide (3a) and bicalutamide (4), encounter resista...

The herbicide, 2,4′-dinitro-4-trifluoromethyl diphenylether (fluorodifen), is eleaved in peanut to give the metabolite, S-(2-nitro-4-trifluoromethylphenyl)-glutathione. A comparison of the glutathione conjugate isolated from treated peanut leaves and from in vitro pea epicotyl glutathione S-tra...

A “soluble” glutathione S-transferase that catalyzes the cleavage of the herbicide, 2,4′-dinitro-4-trifluoromethyl diphenylether (fluorodifen), was isolated and partially characterized from epicotyl tissues of pea seedlings. A 32-fold purification of the enzyme was achieved by differential ce...

When [14C]F3-fluorodifen (2,4′-dinitro-4-trifluoromethyl diphenylether), carbonyl-[14C]CDAA (N,N-diallyl-2-chloroacetamide), and carbonyl-14C-propachlor (2-chloro-N-isopropylacetanilide) were fed to rats, 57 to 86% of the 14C was excreted via the urine within 48 hr. Although very little radioac...

The metabolism of fluorodifen (p-nitrophenyl α,α,α,-trifluoro-2-nitro-p-tolyl ether) by soil microorganisms in the presence or absence of other carbon and nitrogen sources was studied. The degradation of this herbicide continued for 5 days, when benzoate or acetate and ammonium sulphate were ...

Glutathione transferases (GSTs) from the tau class (GSTU) are unique to plants and have important roles in stress tolerance and the detoxification of herbicides in crops and weeds. A fluorodifen-induced GST isoezyme (GmGSTU4-4) belonging to the tau class was purified from Glycine max by affinity...

The glutathione transferases (GSTs) are members of a superfamily of enzymes with pivotal role in the detoxification of both xenobiotic and endogenous compounds. In this work, the generation and characterization of transgenic tobacco plants over-expressing tau glutathione transferases from Citrus...

Publisher SummaryThe pyridazine nucleus is a π-deficient aromatic heterocycle. Each nitrogen atom of the 1,2-diazine activates its α- and γ-position for nucleophilic attack. Consequently, all ring carbon atoms are deactivated for electrophilic substitution. The first naturally occurring hexah...

Special tetrasubstituted pyridazines are potent fungicides by promoting the tubulin polymerisation, hereby disrupting the microtubule dynamics in the fungus. They are monocyclic analogs of similar substituted triazolopyrimidines and pyridopyrazines with the same mode of action. The fungicidal ac...

Reactions of [Pt2(μ-Cl)2(C8H12OMe)2] (1) (C8H12OMe = 8-methoxy-cyclooct-4-ene-1-yl) with various anionic chalcogenolate ligands have been investigated. The reaction of 1 with Pb(Spy)2 (HSpy = pyridine-2-thiol) yielded a binuclear complex [Pt2(Spy)2(C8H12OMe)2] (2). A trinuclear complex [Pt3(Spy...

An amphiphilic liquid crystal (LC) block copolymer based on aliphatic polycarbonate with pendant cholesteryl groups was synthesized by the coupling reaction. The structure and LC properties of the obtained block copolymer were characterized using FT-IR, 1H NMR, DSC, POM and XRD. The results show...

Molecularly imprinted polymers are being increasingly investigated as selective sorbents. For the recovery of cholesterol from aqueous media, the utility of the molecularly imprinted polymers has been limited by modest capacities and selectivities, especially when compared with alternative adsor...

ABSTRACTA cholesteryl carbonate ester was prepared and evaluated as a possible thermotropic liquid crystal excipient for dry powder inhalers. Cholesteryl palmityl carbonate (CPC) was synthesized, and the phase behavior was characterized by differential scanning calorimetry, transmission electron...

Binary mixtures of cholesterol and fully-condensed octakis[{2-(3,4-epoxycyclohexyl) etyl}dimethyl-silyloxy]octasilsesquioxane (OE-POSS) were characterized using Langmuir trough for obtaining surface pressure-area isotherms. The most characteristic feature of the mixed films is the presence of tw...

A study was made of the TLC properties of the 3-beta-substituted esters, ethers, carbonic acid esters and halogen derivatives of cholesterol.As regards the TLC properties it can be stated as a general correlation that the same solvent systems are suitable for the separation of these groups of co...

A homologous series of 1-n-alkyl-derivatives of aminoglutethimide (AG) has been synthesised and tested for inhibitory activity towards the cholesterol side chain cleavage enzyme (desmolase) from bovine adrenals and human placental aromatase in an attempt to find a selective aromatase inhibitor. ...