The reaction of 1,2-bis(diphenylthioylphosphino)hydrazine (L) with copper(I) and mercury(II) halides affords the complexes, [{CuLX}2] (X = I, Br or Cl), [HgLX2] (X = Cl or Br) and the tetrametallic complex, [{L(HgI2)2}2]. Single crystal X-ray structures have been performed on the uncoordinated l...

The base-catalysed addition of diphenylphosphine to the diarylethynes RCCR′ (R=R′=2-pyridyl 1; R=R′=3-pyridyl 2; R=2-pyridyl, R′=3-pyridyl 3; R=phenyl, R′=2-pyridyl 4, 3-pyridyl 5, 2-pyrimidyl 6) yield diphosphines of general formula Ph2PCH(R)CH(R′)PPh2 together with alkene by-products P...

Kinetic data for the reaction of Lewis bases (L) with (diphos)M(CO)4 (diphos = 1,2-bis(diphenylphosphino)ethane; M = Cr, Mo) support a mechanism in which reversible dissociation of CO is followed by attack of L on the resulting five-coordinate intermediate. Activation parameters for the carbonyl...

Due to the importance of aldose reductase (ALR2) as a potential drug target in the treatment of diabetic complications, there are increasing interests in design and synthesis of ALR2 inhibitors. Here, we prepared 1,2-benzothiazine 1,1-dioxide acetic acid derivatives and investigated their inhibi...

Two new series of 1,2-benzisothiazol-3(2H)-one-1,1-dioxide derivatives containing either five membered heterocyclic rings or aryl hydrazones were synthesized and evaluated for their in vitro COX-1/COX-2 inhibitory activity. In vivo anti-inflammatory evaluation revealed that benzenesulfonamides b...

A method for the stereospecific synthesis of 2-[(2H-1,2,4-benzothiadiazine-1,1-dioxide-3-yl)thio]propanoic acids 1 has been developed. A new example of enantiomer self discrimination which can be conveniently used for the determination of enantiomeric purity by 1H NMR spectroscopy without a chir...

3-[(2H-1,2,4-Benzothiadiazine-1,1-dioxide-3-yl)thio]-2-methylpropanoic acids were synthesized from the corresponding 3-mercaptoderivatives by alkylation with (+) (R)- and (−) (S)-3-bromo-2-methylpropanoic acid methyl ester. The nucleophilic substitution takes place with complete maintenance of t...

Interleukin-2 receptor subunit beta of flounder (Paralichthys olivace, fIL-2Rβ) was annotated on the NCBI, its gene was cloned and characterized functionally in this study. And then the amino acids sequences and tertiary structure of fIL-2Rβ were analyzed, respectively. RT-PCR and ImageJ analy...

In this paper, we present a novel bottom-up salient object detection approach by exploiting the relationship between the saliency detection and the null space learning. A key observation is that saliency of an image segment can be estimated by measuring the distance to the single point, which re...

Addressing topological properties of real-world networks requires the use of null models, of which the most common are random Erdős-Rényi graphs with the same number of nodes and links than the network under study. Yet, these latter graphs are completely structure agnostic, and can therefore be...

BackgroundWhether glutathione S-transferases (GST) null genotypes influence individual susceptibility to leukemia remains controversial. Thus, we performed this meta-analysis to better analyze potential influences of GST null genotypes on individual susceptibility to leukemia.

In this paper, we derive the Bishop frames of the pseudo null curve and show that its normal Bishop vectors N1 and N2 can be obtained by applying the hyperbolic rotation and the composition of three rotations about two lightlike and one spacelike axis to the Frenet vectors N and B respectively. ...

A recent proposal known as unlicensed LTE offers cost-effective capacity extension to the cellular network operators in which LTE operators bundle the unlicensed spectrum in 5 GHz UNII bands with their licensed spectrum via carrier aggregation. But, unlicensed spectrum requires coexistence among...

This work is devoted to the study of null rules applied to the detection of intervals where functions have lower regularity. Null rules were introduced in the construction of automatic quadrature routines and some of these are currently the core of algorithms for automatic quadrature.The calcula...

Theoretical models used in database research often have subtle differences with those occurring in practice. One particular mismatch that is usually neglected concerns the use of marked nulls to represent missing values in theoretical models of incompleteness, while in an SQL database these are ...

We prove that a totally umbilic null hypersurface whose Ricci curvature vanishes on null tangent vectors is contained in a null cone. For this, we use the rigging technique to induce a Riemannian metric on the null hypersurface, which is locally decomposed as a warped product with a one-dimensio...

We have designed novel tropinone-thiazole derivatives that showed high antiproliferative activity against a variety of cancer cell lines via caspase 3/7 activation mechanism. Among the derivatives, compounds 3b-3h were found to exhibit high activity against human leukemia (MV4-11), human lung ca...

The reaction of perfluorobiacetyl with thiourea produced 4,5-dihydroxy-4,5-bis(trifluoromethyl)imidazolidine-2-thione, mainly in trans-form, in a yield of ∼60%. 4,5-Dihydroxy-4,5-bis(trifluoromethyl)imidazolidine-2-thione(one) were introduced for the first time in the condensation with thiourea...

The strong therapeutic potential of CB2 receptor agonists for use as anti-inflammatory agents that lack psychiatric side effects has attracted substantial interest. We herein describe the rational design and synthesis of novel thiazole and benzothiazole derivatives and the evaluation of their bi...

A series of novel 2-(5-hydroxy-5-trifluoromethyl-4,5-dihydropyrazol-1-yl)-4-(coumarin-3-yl)thiazoles (6) were synthesized by condensing 3-(2-bromoacetyl)coumarins (4) with various 5-hydroxy-5-trifluoromethyl-4,5-dihydropyrazol-1-thiocarboxamides (5), obtained by the reaction of thiosemicarbazide...