The demand for purified hydrogen as a new green energy source has dramatically increased during last years. In this study, different -Matrimid®- Deca-dodecasil 3R (DDR) type zeolite mixed matrix membranes were synthesized for Hydrogen purification from Methane. Results demonstrated that existenc...

BackgroundIn the cocaine addiction the development from transient into persistent neuroplastic changes strongly involves the glutamatergic system. In this respect, among glutamatergic receptors special attention is paid to the group II of metabotropic glutamatergic receptors (mGlu2/3R) which are...

In this study, we investigated the effects of the drugs, palonosetron hydrochloride, bevacizumab and cyclophosphamide, on human serum paraoxonase-I (hPON1) enzyme activity in in vitro conditions. The enzyme was purified ∼231-fold with 34.2% yield by using ammonium sulphate precipitation, DEAE-S...

BackgroundRocuronium causes pain and withdrawal movement during induction of anesthesia. In this study, palonosetron was investigated to have analgesic effect on the reduction of rocuronium-induced withdrawal movement.

It is proposed that the low skin permeation potential of palonosetron could be enhanced by the inclusion of chemical permeation enhancers. The objective of this study is to evaluate the influence of various chemical enhancers on the transdermal permeation of palonosetron. Different drugs in adhe...

Clinical potential of palonosetron in oral therapy is mainly limited by low permeability. The purpose of this study was to develop oral mucoadhesive film with palonosetron and evaluate its prospective for buccal delivery. Films were prepared by solvent casting method using proloc 15 and eudragit...

Objective: Postoperative nausea and vomiting (PONV) are two of the most frequent adverse effects of anesthesia. PONV prolongs hospital stays and also delays the recovery of patients. In this study, the effects of ondansetron, tropisetron and palonosetron on PONV in patients who had undergone mid...

Four dogs with chronic gastric fistulas were given intravenous bombesin nonapeptide (B9), ranatensin, and litorin by constant infusion for 90 min at 1.2 μg·kg−1·h−1 on separate days. A dose response study with substance P (1.5, 3.0, 60, 18 and 54 μg·kg−1·ht-1 was also carried out and all t...

An antibody to des-pyroglutamyl ranatensin (RT 2-11) has been prepared and has been used to histochemically and biochemically identify ranatensin-like immunoreactivity (irRT) in the rat brain. The most prominent stained cell group was situated in the dorsal tegmental pons. Areas of immunoreactiv...

The effects on ingestive behavior of the naturally occurring bombesin-like peptides ranatensin and litorin were studied in comparison to those of bombesin by intracerebroventricular pulse injection or by continuous infusion in the rat. Ranatensin and litorin, like bombesin, proved to inhibit dri...

Antibodies specific for the carboxyl-terminal regions of bombesin and of ranatensin were used to study the tissue distribution of substances immunochemically similar to these two peptides in three amphibian species. Brain extracts of Rana catesbiana, Rana pipiens, and Xenopus laevis all containe...

Renatensin an undecapeptide isolated from Rana pipiens skin was found to be pressor in dogs. The threshold intravenous dose was similar to angiotensin (0.01 μg/kg) but the dose response curve was more horizontal and the duration of action of ranatensin was substantially longer. Pretreatment wit...

Previous studies have demonstrated a neuronal system containing an immunoreactive ranatensin-like peptide (irRT) in rat brain. The results of the present study describe the ascending projections of a prominent irRT cell group in the pons. A major pontine irRT fiber system was shown to innervate ...

In an attempt to improve the efficacy and stability of current, clinically used artemisinins, a series non-hemiacetal ester derivatives of artemisinin were synthesized and evaluated for their in vitro antiplasmodial and anticancer activities as well as cytotoxicities. These esters were synthesiz...

The phosphine-catalyzed asymmetric [4+2] annulation of vinyl ketones with more easily available oxindole-derived α,β-unsaturated imines has been further developed in the presence of an easily available multifunctional thiourea-phosphine catalyst derived from natural amino acid, providing the e...

The steric regulations imparted by the substituent at N1 in lithium mediated asymmetric aldol reactions of conformationally restricted 3-aryl-1-((S)-1-phenylethyl)-2-thioxotetrahydropyrimidin-4(1H)-ones governed the formation of anti aldol adducts, by a kinetic reaction pathway. The preferential...

New series of 2-(4-methylsulfonylphenyl) and 2-(4-sulfamoylphenyl)pyrimidines were synthesized and evaluated for their ability to inhibit cyclooxygenase-2 (COX-2). COX-1 and COX-2 inhibitory activity of these compounds was determined using purified enzyme (PE) and human whole blood (HWB) assays....

Structure-activity relationships for rigid analogues of combretastatin A-4 (CA-4) were investigated, leading to the discovery of a series of 3,4-diaryl-1,2,5-oxadiazole-N-oxides. Among them, 7n′ and 7n′′ showed remarkable antiproliferative activities against three cancer cell lines in nanomol...

A novel efficient synthetic approach to 4-amino-2-trifluormethyl quinoline derivatives is described via palladium-catalyzed cascade reactions of isocyanides with readily available N-(ortho-iodo)aryl enamines under mild conditions. The target heterocycles can be found in many natural products or ...

2-(Quinolin-4-yloxy)acetamides have been described as potent and selective in vitro inhibitors of Mycobacterium tuberculosis (Mtb) growth. Herein, a new series of optimized compounds were found to demonstrate highly potent antitubercular activity, with minimum inhibitory concentration (MIC) valu...