Halosulfuron methyl, a fast-acting herbicide and is absorbed into leaf tissue within 1–2 days and translocated through the vascular system, interrupting amino acid production within the plant, can be detected using glassy carbon electrode the technique of adsorptive stripping voltammetry. The a...

Acetamiprid, a neonicotinoid pesticide, is reported to have adverse sublethal effects on non-target beneficial organisms. Halosulfuron-methyl (HM), one of the most widely used herbicides in agriculture, has high ecotoxicity to aquatic plants and animals. In this study, a GC–MS-based metabolomic...

Using 1-butyl-3-[3-(N-pyrrole)propyl]imidazolium tetrafluoroborate ionic liquid as functional monomer, a nanoporous polymeric film modified glassy carbon electrode was fabricated with potential step from 0 V to 1.2 V. Followed by anionic exchanging, a hydrophobic electrochemical interface bearin...

Squamous cell carcinoma antigen (SCCA) is a good specific antigen for cancer diagnosis specifically for squamous cell carcinomas. In this study, 3-amine-N-[3-(N-pyrrole)propyl]imidazole bromide (APPIBr) ionic liquid was successfully synthesized and characterized by 1H NMR, HPLC-MS and FTIR. APPI...

1-[3-(tert-Butoxycarbonylamino)propyl]-3-[3-(N-pyrrole)propyl]imidazolium tetrafluoroborate [(t-Boc-APPPI)BF4], which is a novel pyrrolyl-functionalized ionic liquid, was synthesized and characterized. Subsequently, it was electrochemically deposited onto a glassy carbon electrode surface to fab...

In the continuing search for novel compounds targeting serotonin 5-HT2A, 5-HT2C, and serotonin transporter, new arylpiperazine-containing pyrrole 3-carboxamide derivatives were synthesized and evaluated. Based on the lead reported previously, structural modifications regarding N-(3-(4-(2,3-dichl...

The synthesis and fluorescence characterization of a new pyrrole derivative (PyPDG) containing the electron donor–acceptor dansyl substituent is reported. The effects of temperature and solvent polarity on the steady-state fluorescence of this compound are investigated. Our results show that Py...

Excess lipid accumulation in the arterial intima and formation of macrophage-derived foam cells in the plaque could cause atherosclerotic lesion. Cholesterol absorption inhibitors could suppress the lipid accumulation of human macrophage, inflammatory response and the development of atherosclero...

Three monomers 6-[3′-N-pyrrolpropoxy]-2-hydroxyacetophenone (1), 5-(3′-N-pyrrol propoxy)-2-hydroxyacetophenone (2) and 4-(3′-N-pyrrolpropoxy)-2-hydroxyacetophenone (3) were synthesized and their poly(pyrrole) films were electrodeposited on glassy carbon (GC) and Indium tin oxide (ITO) conduct...

Although brain pathways activated by sepsis may respond acutely to endotoxin administration, the long-term central response to sepsis is not known. We prepared male rats for hormonal sampling at the circadian nadir (AM) and peak (PM) after cecal ligation and puncture (CLP) or sham surgery. Diurn...

Flesinoxan acts as a full 5-HT1A receptor agonist and displays anxiolytic and anti-depressant properties. 5-HT1A receptor agonists, including flesinoxan, increase corticosterone (B) levels in the blood and reduces 5-HT1A receptor mRNA expression in the hippocampus. In this study, we examined whe...

BackgroundVolumetric changes and glial pathology have been reported in the central nervous system (CNS) of patients with depressive disorder, an illness often associated with elevated glucocorticoid levels. Glucocorticoids reduce gliogenesis in the adult rat CNS. Electroconvulsive seizure (ECS)-...

Corticosterone, a principal glucocorticoid synthesized in the rodent adrenal cortex and secreted in response to stress, is reported to produce a biphasic effect on animal behavior. In this study, we determine that corticosterone administration produced different effects on depression-like behavi...

SummaryNPSR1 is a G protein coupled receptor expressed in multiple brain regions involved in modulation of stress. Central administration of NPS, the putative endogenous ligand of NPSR1, can induce hyperlocomotion, anxiolytic effects and activation of the HPA axis. The role of NPSR1 in the brain...

Using a rigorous extraction procedure and radioimmunoassay we have established that aldosterone 21-sulphate concentrations in adrenal vein specimens are higher than peripheral concentrations. Incubations of homogenates of adrenal glands and adenomata in vitro also produced aldosterone 21-sulphat...

SummaryHigh level of serum corticosteroid is frequently associated with depression, in which a notable HPA (hypothalamus-pituitary-adrenal) axis hyperactivity is often observed. There are two types of corticosteroid receptors expressed in the hippocampus that provide potent negative feedback reg...

I. J. Scherer, P. V. Holmes, R. B.S. Harris. The importance of corticosterone in mediating restraint-induced weight loss in rats. PHYSIOL BEHAV 00 (0) 000-000, 2010. Rats restrained for 3 h/day for 3 days (RR) lose weight and do not return to the weight of non-restrained controls once restraint ...

Introducing a spiro-γ-lactone at position 17 of an estradiol nucleus provokes a potent inhibition of 17β-hydroxysteroid dehydrogenase (17β-HSD) type 2. Synthesis of such a compound, namely 6 (3-hydroxy-19-nor-17α-pregna-1,3,5(10)-triene-21,17β-carbolactone), was performed in five steps, sta...

Methyl-2-fluoro-3-(N-benzoylamino)-3-phenylpropanoate 2 and 3, fluorine analogs of the C-13 side chain of taxol, were synthesized by electrophilic fluorination of the dianion of methyl (R)-(−)-(N-benzoyl)-3-amino-3-phenylpropanoale (4).

The condensation reaction of 5-N-benzoylamino-1,3,4-thiadiazole-2-acetonitrile with aromatic aldehydes in acetonitrile, in the presence of piperidine, has been investigated spectrophotometrically at 50–70°C. The reaction follows second order kinetics overall; first order in each of the reactan...