The electrooxidation of cytosine on common commercially available screen-printed carbon electrodes was investigated. To characterize the processes on the electrode surface, the oxidation products were analyzed by online electrochemistry-capillary electrophoresis-mass spectrometry. Capillary elec...

Herein, a simple one-pot aqueous method was developed for synthesis of AgPt hollow alloyed nanostructures (AgPt HANS) with polyvinylpyrrolidone (PVP) and cytosine as the dispersing agent and eco-friendly growth-director, respectively. The synthesized architectures displayed the improved catalyti...

The interactions of Diclofenac Sodium Salt (DSS) with water and aqueous sorbitol as a function of temperature have been investigated by volumetric, acoustic and conductance studies. Densities, speed of sound and conductance of DSS in water and aqueous solutions of sorbitol (0.002, 0.004, 0.006) ...

Amino acid amides react with diethyl oxalate and sodium ethoxide to yield 6-substituted piperazine-2,3,5-triones, which can be mono-alkylated at N4, bis-alkylated at N4 and C6, or tris-alkylated at N4, N1, and C6 under mild basic conditions; this provides access to i) α,α-disubstituted cyclic ...

A series of new palbociclib analogs by extensive functionalization of the tail piperazine ring with various carbamates and amides have been synthesized. All the palbociclib derivatives were evaluated for their cytotoxic activities against MCF-7 cell line. From the anti-proliferation activity res...

A photocrosslinked membrane (M-Cl) based on vinyl-pyrrolidone/butyl acrylate containing ethylene glycol dimethacrylate as a crosslinking agent and methacryloyl chloride as reactive monomer has been prepared for further functionalization. A series of hydroxy substituted piperazine naphthalimide c...

36 novel piperazine (PZ)-based amine blends were investigated for their thermal stability for CO2 capture. These amines include 7 imidazoles, 8 cyclic and long-chain diamines, 12 tertiary amines, 4 hindered amines, 3 hindered and tertiary amino acids, and 2 ether amines that were selected based ...

17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) is a promising therapeutic target known to play a pivotal role in the progression of estrogen-dependent diseases such as breast cancer, and endometriosis. This enzyme is responsible for the last step in the biosynthesis of the most potent estr...

The synthesis of some 7-hydroxy-14H-naphtho[2,3-a]phenothiazine-8,13-diones containing electron donor and acceptor substituents in the unhydroxylated anthraquinone ring affords colorants of near-infrared absorbing potential. The relative influence of electron donor and acceptor substituents on t...

Condensation of 2-substituted-1,4-dihydroxyanthraquinones with 2-amino-benzenethiol generally results in the elimination of the 2-substituent and formation of 7-hydroxy-14H-naphtho[2,3-a]phenothiazine-8,13-dione (I). In addition to the anticipated replacement of labile 2-substituents such as hal...

A series of bis-pyridinium oximes connected by methoxy alkane linkers were synthesized and their in vitro reactivation efficacy was evaluated against sarin-inhibited human AChE, and data were compared with 2-PAM and obidoxime. Among the synthesized compounds, 1,2-dimethoxy ethylene bis-[4,4′-(h...

We describe a terbium-ligand complex (TbL) for a microtiterplate assay for phosphate (P) in the 0.3–100 μmol L−1 range based on luminescence quenching. As the pH optimum is at neutral pH (7.4) the probe is quenched by both, primary (H2PO4−) and secondary phosphate (HPO42−). The LOD is 110 nmol...

The hydrodeoxygenation of guaiacol, as a pyrolysis oil representative model compound, was carried out over a Pd/C catalyst using a liquid hydrogen source of 2-propanol (2-PrOH) as an alternative to hydrogen gas. The effects of reaction temperature (190–230 °C), initial nitrogen pressure (0.5–...

The behavior of 2-(2-hydroxy-benzylidene)-cyclohexan-1-one (BC) in the acidic and basic media was investigated. In acidic conditions a new dimeric structure 4′a-methoxy-2,2′,3,3′,4′,4′a,9′,9′a-octahydro-1H, 1′H-4,9′-bixanthene (XTC) was isolated. The structures of BC and XTC were confir...

The conformational free energy of the hydroxyl group of 4-hydroxycyclohexanone oxime has been found to be 0.33 and 0.61 Kcal./mole in pyridine and D2O, respectively. These values are intermediate to those of the hydroxyl group of cyclohexanol and 4-hydroxycyclohexanone in the corresponding solve...

para-Substituted benzoic acid esters of cyclohexanol, 1,4-dihydroxycyclohexane, 4-hydroxy-cyclohexanone and of the corresponding exo-methylene derivative were synthesized and the conformational equilibria of the cyclohexane skeleton studied by low temperature 1H and 13C NMR spectroscopy. The geo...

We report a new synthesis and our study of the mechanism of formation of substituted 1-trifluoromethyl and 1-perfluoroalkyl-3-(phenylamino)prop-2-en-1-one starting from 3-(R-phenoxy)-3-perfluoroalkyl-prop-2-enals and arylamines. Reactivity study of the intermediates confirmed that 3-perfluoroalk...

Reaction of 2,3-dichloro-5,6-dicyanopyrazine (1) with amines gave mono-substituted or bis-substituted products (2a-h). Reaction of 1 with thioacetamide as well as 2,3-bis(N-methylamino)-5,6-dicyanopyrazine (2c) gave 1,4,6,9-tetraaza-2,3,7,8-tetracyanothianthrene (5) or 2,3,7, 8-tetracyano-1,4,6,...

A novel series of luminescent low molecular mass materials containing a 2,3-dicyanopyrazine central core were synthesized through an esterification reaction between diphenol 10 and different aromatic carboxylic acids 1–6, containing terminal long alkyl chains. They have a similar V-shaped geome...

By the method of polarizing microscopy, a chiral nematic phase formation of the 4-(n)alkoxy-4′-cyanobiphenyls (n = 3,4,5,6,7,8) nematic mixtures (CB6) was observed under the influence of 1R(+)1′,7′,7′-trimethylbicyclo[2.2.1]heptane[2′,3′-b]-2,3-dicyanopyrazine (R(+) СDCP). The values of c...