The hematopoietic system is one of the potential targets of lead intoxication. Recognition of the lead-related deleterious outcomes promotes us to explore the potential therapeutic intervention. Here, we show that ginsenoside Rg1 (Rg1), extracted from the Chinese herb Panax ginseng, remarkably a...

Recently, numerous efforts have been reported on improving the properties of perovskite absorber, which has a direct and significant influence on the photovoltaic performance of solar cells. In this paper, lead acetate was introduced into stoichiometric lewis acid-base perovskite precursor to pr...

The impressive increase of power conversion efficiency of hybrid perovskites within a few years has made perovskites one of the most promising materials for photovoltaic applications. However, the route to their commercialization necessitates the establishment of reliable and reproducible large–...

Chemical solution deposition is a promising technology to fabricate YBCO superconducting thin films due to its low-cost advantage. As found in our previous study, the addition of lead acetate in precursor solution could enhance the critical current density of YBCO films, since the deteriorating ...

Hydroxynitrile lyase from the Japanese apricot (Prunus mume) catalyzes the formation of several aliphatic cyanohydrins in an asymmetric fashion. By employing a biphasic reaction system, aliphatic aldehydes with various structural features can be converted to the corresponding (R)-cyanohydrins wi...

A new hydroxynitrile lyase (HNL) was isolated from the seed of Japanese apricot (Prunus mume). The enzyme has similar properties with HNL isolated from other Prunus species and is FAD containing enzyme. It accepts a large number of unnatural substrates (benzaldehyde and its variant) for the addi...

Two series of anion-exchange membranes have been produced by photo-initiated copolymerization of 4-vinylpyridine and divinylbenzene (DVB) within the pores of polypropylene microfiltration membranes followed by quaternization of the pyridine nitrogen atoms. The membranes were tested for use in ac...

Two series of membranes have been produced by photoinitiated polymerization of 4-vinylpyridine (4VP) and divinylbenzene (DVB) within the pores of polypropylene microfiltration membranes. The first series was comprised of membranes with varying mass gain and constant DVB content. The second serie...

In the present study, the performance, behavior and mechanism of synthetic poly(2-vinylpyridine) resin (WH-225) adsorbing 5-sodiosulfoisophthalic acids (SIPA) from the aqueous solution were investigated, and two commercial adsorbents, namely, hypercrosslinked adsorbent NDA-100 and macroporous ad...

Copolymer membranes composed of chloromethylstyrene and divinylbenzene were reacted with 4-vinylpyridine and then trimethylamine to prepare highly tight anion exchange membranes. When 4-vinylpyridine reacted with chloromethyl groups of the copolymer membranes, 4-vinylpyridine polymerized in the ...

WAY-100635 [N-(2-(1-(4-(2-methoxyphenyl)piperazinyl)ethyl))-N-(2-pyridinyl)cyclohexanecarboxamide] 1 and its O-desmethyl derivative DWAY 2 are well-known high affinity 5-HT1A receptor antagonists, which when labeled with carbon-11 (β+; t1/2 = 20.4 min) in the carbonyl group are effective radiol...

There is still a great demand in the clinic for the drugs which can overcome a variety of imatinib resistant ABL mutants. Starting from a type I inhibitor axitinib, which has been reported to overcome ABL-T315I mutant induced resistance, through a structure guided drug design approach and bindin...

A novel cathodically coloring viologen electrochrome: 1,1′-bis(2-(1H-indol-3-yl)ethyl)-4,4′-bipyridinium diperchlorate (IEV), comprising of a 4,4′-bipyridyl core, sandwiched between two indole moieties, was synthesized using 3-(2-bromoethyl)-indole. An electrochromic device (ECD) was assemble...

Novel reagents for the synthesis of 1-substituted uracil and thymine derivatives have been developed. The aminolysis of 2- or 4-nitrophenyl 3-ethoxyacryloylcarbamate and 3-ethoxy-2-methylacryloylcarbamate with a variety of primary amino derivatives proceeded smoothly under very mild reaction con...

A new sulfonylurea, glimepiride (HOE 490), has been developed for the glycemic control in non-insulin-dependent diabetes mellitus. We examined the effect of glimepiride on glucose and insulin levels in KK-Ay mice, an animal model of non-insulin-dependent diabetes mellitus, which is characterized...

Affinity chromatography is a convenient way of purifying proteins, as a high degree of purity can be reached in one step. The use of tags has greatly contributed to the popularity of this technique. However, the addition of tags may not be desirable or possible for the production of biopharmaceu...

In Gram-negative bacteria, type II and type III secretion and filamentous phage assembly systems use related outer membrane proteins for substrate-specific transport across the outer membrane. We show here that the specificity domain of the phage f1 outer membrane protein pIV is contained within...

Synthesis of the Klebsiella oxytoca outer membrane secretin PulD, or its membrane-associated core domain, in a liposome-supplemented Escherichia coli in vitro transcription–translation system resulted in the formation of multimers that appeared as typical dodecameric secretin rings when examine...

The C-terminal core domain of the secretin PulD from Klebsiella oxytoca forms heat-resistant dodecameric complexes within less than 10 min in an Escherichia coli in vitro transcription-translation system containing liposomes, and is toxic when made in the cytoplasm without a signal peptide. Rand...

The DNA-binding protein Sac7d was previously modified to bind with high affinity to the N domain of the outer membrane secretin PulD from the bacterium Klebsiella oxytoca. Here, we show that binding of the Sac7d derivatives (affitins) to PulD is sensitive to conformational changes caused by dena...