Reactions of symmetrical 1,1′-diphenylthiodiacetic acid dihydrazide and triethyl orthoesters in the presence of catalytic amount of glacial acetic acid resulted in the formation of three heterocyclic products: the appropriate bis(1,3,4-oxadiazol-2-yl-phenylmethyl) sulfides, 2-benzyl-1,3,4-oxadi...

Discovery of novel antimycobacterial compounds that work on distinctive targets and by diverse mechanisms of action is urgently required for the treatment of mycobacterial infections due to the emerging global health threat of tuberculosis. We have identified a new class of 5-ethyl or hydroxy (o...

1-(2-Azido-2,3,-dideoxy-β-D-erythro-pentofuranosyl)thymine (2′-N3ddThd) was synthesized from 1-(5-O-trithyl-2,3-anhydro-β-D-lyxofuranosyl)thymine by two different procedures. Method A prepared the title compound by opening of the oxirane ring with LiEt3BH followed by mesylation of the 2′-hyd...

An alternate enantiospecific synthesis of methyl (S)-7-tert-butoxycarbonyl-2,3,4,5-tetrahydro-4-methyl-3-oxo-1H-1,4-benzodiazepine-2-acetate (5) is reported. The key step, which involves an intermolecular displacement of the activated aryl fluoride (9) by L-aspartic acid β-methyl ester, proceed...

Methyl-esterification of oxygenates such as alcohols, aldehydes and carboxylic acids were carried out by employing copper and copper/palladium based catalysts using TBHP. In this reaction, TBHP plays dual role as oxidizing and methylating agent. Cu and Cu-Pd based nanoperticles (NPs) were prepar...

Ortho/para-aminobenzoic acids and corresponding methyl esters were selected as the diazo components to couple with two mono functional group transformation (FGT) precursors with different pyridine N-substituted groups [1-ethyl-6-((3-methoxypropyl)amino)-4-methyl-2-oxo-1,2-dihydropyridine-3-carbo...

The synergetic effects between the O/NH⋯F− anionic hydrogen-bonding and conventional O/NH⋯O hydrogen-bonding interactions in the 1:2 (F−:N-(Hydroxymethyl)acetamide) ternary systems are investigated at the B3LYP/6-311++G** and MP2/6-311++G** levels. The non-additivity energies are also calculated...

An acid functionalized porous organic hyper-cross-linked polymer (HCP) derived from benzene monomer was prepared for catalytic dehydration of carbohydrates into 5-hydroxymethyl furfural (HMF) in a DMSO solvent. Systematic characterizations of the HCP catalysts including essential structural prop...

Nanocrystalline Li5La3Ta2O12 powders were prepared by sol–gel method, in which acetic lithium, tantalum ethoxide, and lanthanum nitrate were used as starting materials, while ethylene glycol was used as solvent and acetic acid was used to control the pH value. Pure garnet-like Li5La3Ta2O12 powd...

In this paper, a new sol–gel method was developed to prepare the LiTaO3 powder and thin film. In this method, hydrogen peroxide aqueous solution (H2O2) reacts with tantalum and lithium ethoxides ethanol solution. The property of transformation into pure LiTaO3 was demonstrated through annealing...

Flexible-transparent-lithiated-lithium tantalum oxide (LixTaOyCz) films deposited onto 40 Ω/□ flexible polyethylene terephthalate/indium tin oxide substrates by low temperature plasma polymerization with an atmospheric pressure plasma jet (APPJ) at various flow rates oxygen gases are investiga...

Enhanced lithium electrochromic performance of flexible tungsten oxide films by the addition of tantalum with an atmospheric pressure plasma jet in a rapid synthesis onto flexible 40 Ω/□ polyethylene terephthalate/indium tin oxide substrates was investigated. The flexible organic–inorganic hy...

Effects of reflux ratio, water addition and content of water in ethanol on the purity and yield of tantalum ethoxide during vacuum distillation were investigated under the operational conditions of pressure of 1 kPa, oil bath temperature of 210–230 °C, and outlet temperature of 190 °C. The co...

An efficient and simple approach for the solid-phase synthesis of 2,4,6-triaminopyrimidines and 2-alkyl-4,6-diaminopyrimidines is described. Primary amines were immobilized on 2-(4-formyl-3-methoxyphenoxy)ethyl polystyrene resin via reductive amination. Attachment of two different 4,6-dichloropy...

Huntington's disease (HD) is a rare genetic disease associated with the degeneration of GABAergic striatal projection neurons in the basal ganglia leading to movement disorders with behavioral symptoms for which there is presently no therapy. Abnormally high levels of monoamine oxidase (MAO...

Repeated treatment with the dopamine D2/D3 receptor agonist quinpirole produces a sensitized behavioral response in rats manifested as an increase in locomotor activity. Pre-treatment with certain monoamine oxidase inhibitors, such as Ro 41-1049 [N-(2-aminomethyl)-5-(3-fluorophenyl)-4-thiazoleca...

Emerging evidence implicates the upregulation of matrix metalloproteinase (MMP)-9/2 in the dorsal root ganglion (DRG) and spinal cord as a contributor to the pathogenesis of chronic pain. In the current study, the expression of MMP-9/2 in wounded tissue, ipsilateral DRG, and the spinal dorsal ho...

BackgroundUltraviolet (UV) radiation has been reported to influence epigenetic regulation by affecting the expression of genome regulators such as DNA methyltransferase 1 (DNMT1). DNMT1 is a “gene silencer,” that is responsible for the maintenance of DNA methylation and contribution to de novo...

BackgroundBurns induce microvascular hyperpermeability. We hypothesize that this occurs partly through an imbalance between matrix metalloproteinases (MMPs) and endogenous MMP inhibitors such as tissue inhibitors of metalloproteinases (TIMPs), and that such derangements can be attenuated with th...

MicroRNAs (miRNAs) are emerging as important regulators in osteoarthritis (OA) pathogenesis. In our study, a real-time PCR assay revealed that miR-483-5p was upregulated in articular cartilage from OA patients and experimental OA mice induced by destabilization of the medial meniscus compared to...