This study introduces the surface modification of the low carbon steel by an effective corrosion protective composite film based on Nd-PAA-BI (neodymium-polyacrylic acid-benzimidazole). The surface characteristics of the samples were investigated by FE-SEM (Field emission scanning electron micro...

Nd(OH)3 particles of nanometer size have been prepared by using different methods. The obtained neodymium hydroxide samples have been investigated by using the FT-Raman spectroscopy, X-ray diffraction, transmission electron microscopy as well as field emission electron microscopy. Observable cha...

The Mg3Al1−xNdx layered double hydroxides (LDHs) were synthesized via aqueous sol–gel synthetic route and the influence of the Nd3+ doping on the Mg3Al1−xNdx LDHs properties was estimated for the dopant concentration varied in the range of 1–10 mol%. The microstructure and morphology of the sy...

The enthalpies of solutions of La(OH)3 (cr), Nd(OH)3 (cr), Sm(OH)3 (cr) and Am(OH)3 (cr) and of La (cr), Nd (cr) and Sm (cr) in 6.00 mol dm−3 HCl have been measured at 298.15 K. From these measurements, the following standard molar enthalpies of formation ΔfHmo (kJ mol−1) are calculated as La(O...

The dinuclear platina-β-diketone [Pt2{(COMe)2H}2(μ-Cl)2] (1) was found to react with 2-(ROCH2)C5H4N (R =  Me, 2a; H, 2b) yielding a cationic mononuclear platina-β-diketone [Pt{(COMe)2H}{2-(MeOCH2)C5H4N}]Cl (3) and an acetyl(chloro)platinum(II) complex [Pt(COMe)Cl{2-(HOCH2)C5H4N}] (4), respect...

A series of 1-acetyl/propyl-3-aryl-5-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-2-pyrazolines were synthesized in one step by condensing suitably substituted propenones, hydrazine and acetic/propionic acid. The newly synthesized pyrazolines were characterized by analytical and spectral data. T...

1-[2-(5-Chloro-2-benzoxazolinone-3-yl)acetyl]-3-phenyl-5-(3-methoxyphenyl)-4,5-dihydro-(1H)-pyrazole (5a), 1-[2-(5-chloro-2-benzoxazolinone-3-yl)acetyl]-3-phenyl-5-(3,4-dimethoxyphenyl)-4,5-dihydro-(1H)-pyrazole (5b) and 1-[2-(5-chloro-2-benzoxazolinone-3-yl)acetyl]-3-(4-methylphenyl)-5-(2,3-dim...

Cancer is one of the most serious health problems worldwide and it is considered the second major cause of mankind deaths. We report the synthesis and spectroscopic characterization of N-(4-chloro-2-{[2-(1H-indol-2-ylcarbonyl)hydrazinyl](oxo)acetyl}phenyl)acetamide (CICHOPA, 5) as a new antiprol...

The reactions of cobalt(II), nickel(II), zinc(II) chlorides and [Pd(DMSO)2Cl2] with 2-acetyl-5-chloro-thiophene thiosemicarbazone (HL) leads to the formation of a series of new complexes: [CoCl2(S-HL)2], 1; [Ni(N,S-L)2], 2 [ZnCl2(S-HL)2], 3 and [PdCl2(N,S-HL)], 4. All the complexes have been cha...

A number of 5′, N6- and C8, N6-disubstituted adenosine analogs was synthesized and tested for inhibition of trypanosomal glyceraldehyde 3-phosphate dehydrogenase. The most active compound, N6-(3-methyl-2-butenyl)-8-(2-thienyl)adenosine, had Ki of 9 μM and was marginally selective for the paras...

A method is described for the quantitative determination of the methyl ester of 2-chloro-3-(4-chlorophenyl)propionic acid (common name chlorphenprop-methyl), the active ingredient of herbicide formulations known under the trade-name Bidisn. The method is proposed for the determination of both te...

A one-pot three component 1,3-dipolar cycloaddition reaction of an aldehyde, α-aminomalonate, and nitroalkene has been developed through binaphthol derived chiral phosphoric acids. This reaction represents one of the most enantioselective catalytic approaches to access structurally diverse pyrr...

The use of diethyl carbonate as a sustainable solvent for organocatalytic asymmetric transfer hydrogenations of 2-substituted quinolines using highly efficient chiral phosphoric acid catalysts with Hantzsch esters as a hydrogen source is reported for the first time. The asymmetric transfer hydro...

(6-Oxo-6H-pyridazin-1-yl)phosphoric acid diethyl esters (3) are efficient and selective coupling agents for equimolar esterification of carboxylic acids and alcohols. Esterification of aliphatic and aromatic carboxylic acids with aliphatic and aromatic alcohols using 3 afforded the corresponding...

Background: T cells are known to play a major role in the pathogenesis of atopic allergic asthma, but it is less clear whether they are involved in occupational asthma caused by low molecular weight chemicals such as plicatic acid. Objectives: We sought to determine whether peripheral blood T ce...

In a cross-sectional survey of 652 workers in a western red-cedar sawmill, we obtained data on symptoms, pulmonary function, immediate skin reactivity to common allergens, nonspecific bronchial responsiveness, total IgE level, and sensitization to plicatic acid conjugated with human serum albumi...

We describe a rabbit model for the study of the immunogenicity and allergenicity of plicatic acid (PA), the small molecular weight compound in western red cedar responsible for occupational asthma in exposed workers. Specific anti-PA IgE as well as IgG antibodies could be raised, depending on th...

Plicatic acid, a low-molecular-weight compound responsible for western red cedar (Thuja plicata) asthma was tested for its ability to activate complement and to generate chemotactic activity from pooled normal human serum (NHS). Dose-dependent complement consumption was found as determined by he...

Bronchoalveolar lavage (BAL) was performed before and 10 minutes after inhalation challenge with plicatic acid in five patients with red cedar asthma. There was a significant release of histamine and leukotriene E4 into the BAL fluid in all the patients after challenge. Inhalation challenge with...

Inhibitors of the Hsp90 molecular chaperone are showing promise as anti-cancer agents. Here we describe a series of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine ATP competitive Hsp90 inhibitors that were identified following structure-driven optimization of purine hits revealed by NMR based screening ...