Simple high performance liquid chromatography (HPLC) methods for the analysis of 4-chlorophenyl methyl sulphide (CPMS), diphenyl sulphide (DPS) and their corresponding sulphoxide and sulphone metabolites in rat liver microsomes are described. The assay methods are based on a reversed phase HPLC ...

The sensitive fluorimetric assay for hydroxy-3-benzpyrene (3-OH-BP) described by Dehnen et al., was used to study the effect of microsomal membrane concentration on the benzpyrene hydroxylase activity.Microsomes from phenobarbital (PB) and methyl-3-cholanthrene (3-MC)-treated rats were used in c...

Outer mitochondrial membrane was isolated from swelled rabbit liver mitochondria and precipitated with Ca++ at a concentration that does not precipitates microsomes. After induction with 20-methyl cholanthrene or Aroclor the outer membrane shows the presence of cytochrome P450 and glucose 6-phos...

Subfractionation of rat liver microsomes by the use of rate-zonal centrifugation has been carried out using both normal and induced rats. Phenobarbital and methyl cholanthrene were found to have very distinctive effects on the distribution of cytochrome P-450 within the microsomal vesicles. The ...

Simple synthetic methods are described for the synthesis of valuable polyfunctional brominated methoxyquinolines 10–13, 20–21, and 24–25. Three regioselective routes are described for convenient preparation of brominated methoxyquinolines at the C-2, C-3, and C-5 positions with consecutive re...

As known, after AC transmission line fault occurs, LCC-HVDC inverter station has three different statuses: no commutation failure, single commutation failure and continuous commutation failure. And the different statuses of inverter station could lead to wrong operation of traditional protection...

We have carried out the optimization of substituents at the C-3 or the C-5 position on the pyrrolidine ring of VLA-4 antagonist 3 with 2-(phenylamino)-7-fluorobenzoxazolyl moiety for the purpose of improving in vivo efficacy while maintaining good aqueous solubility. As a result, we successfully...

Enantiopure methyl esters of 1-alkyl-5-oxo-3-pyrrolidinecarboxylic acids were obtained by enzymatic resolution of the corresponding chiral racemic mixtures. A particularly favourable interaction, also supported by molecular mechanics calculations, was observed between the 1-benzyl derivative and...

This study investigated 13C and 2H isotope fractionation associated with oxidation of three phthalate esters (PAEs) by radical species, including sulfate radical (SO4−) induced by heat-activated persulfate (PS) and hydroxyl radical (HO) induced by UV/H2O2. For persulfate oxidation at pH = 2 and ...

Carbonothioic O,O-acid (monothiocarbonic acid), the sulfur analogue of carbonic acid, is thus far an experimentally unreported molecule of atmospheric and biochemical relevance. Computations at the CCSD(T)/cc-pVQZ//CCSD(T)/cc-pVTZ level of theory reveal that its carbonothioic O,S-acid tautomer i...

A novel procedure that uses FTIR-ATR CO signal area (1690–1800 cm−1) and a standard test method that is used for determination of fatty acid methyl ester in diesel were applied for the quantification of ethyl, propyl, butyl, isobutyl, pentyl, isopenyl, hexyl, heptyl, octyl, decyl, and dodecyl f...

To provide guidance on the selection of proper persulfate processes for the remediation of MTBE contaminated groundwater, MTBE aqueous solutions were treated with three common field persulfate processes including heat activated persulfate, Fe(III)-EDTA activated persulfate and alkaline persulfat...

This paper reports a novel approach for biodiesel production from canola oil in supercritical tert-butyl methyl ether (MTBE) without the addition of a catalyst. Using this technique, canola oil was reacted with MTBE to generate fatty acid methyl esters (FAMEs) and glycerol tert-butyl ether. No g...

The thiopyridazine based scorpionate ligand sodium tris(3,5-di-tert-butyl-6-thioxopyridazin-1(6H)-yl)hydroborate (NaTntBu,tBu) with two tert-butyl substituents in ortho- and para-position of the thio group was synthesized and fully characterized. Corresponding metallaboratrane complexes [M{B(Pnt...

Fatty acid methyl esters (FAMEs) are useful as biodiesel and have environmental benefits compared to conventional diesel. In this study, these esters were synthesized non-catalytically from non-edible vegetable oils: neem oil and mahua oil with two different methylating agents: methanol and meth...

Alkylation reaction catalyzed by concentrated H2SO4 generates hazardous waste H2SO4 containing a large amount of organic pollutants. This study focused on effective utilization and treatment of the waste H2SO4 for simultaneous consumption of H2SO4 and deep oxidative degradation of the organics. ...

When rat liver slices were incubated aerobically at 37 with procaine amide ethobromide (PAEB), the compound readily entered the tissue and attained a concentration in tissue water about three times that in the suspending medium. Accumulation of PAEB in the slices occurred by a process that becam...

Non-nitrogenous onium compounds, such as methyltriphenylphosphonium, n-propyltriphenylphosphonium, hexane-1,6-bis(dimethylsulfonium), tetraphenylarsonium, and N[4(p-chlorophenoxy)-3-chloro] phenylacetamidotriphenylphosphonium, had little or no effect on the rate of biliary excretion of the quate...

The purpose of the study is to design, synthesise and assess the antipsychotic activity of a set of the novel (5-(10-(3-N, N-Dimethylamino) propyl)-10H-phenothiazine-3-yl)-1,3,4-thiadiazo-2-yl) Azodye/Schiff base/Chalcone derivatives. The newly synthesised compound structure was characterised by...

An aqueous solution of ammonium ferrous sulfate–sucrose–xylenol orange in sulfuric acid (FSX) is proposed as a dosimetric system for the processes of gamma irradiation in a range between 0.3 and 6 Gy.This system is based on the indirect oxidation of ferrous ion by an organic compound (sucrose)...