Two syntheses of 6-deoxy-2,4-di-O-methyl-d-allopyranose (11) are described. One route utilised the methylation of methyl 6-deoxy-β-d-allopyranoside 3-carbanilate (4) which occurred with concomitant migration of the ester group to give a mixture of methyl 6-deoxy-2,4-di-O-methyl-β-d-allopyranos...

The 4,6-benzylidene acetal of methyl 2-deoxy-2-fluoro-α,β-d-glucopyranoside underwent inversion at C-3 via an oxidation–reduction sequence, and treatment of the derived 3-acetate with N-bromosuccinimide in carbon tetrachloride gave methyl 3-O-acetyl-4-O-benzoyl-6-bromo-2,6-dideoxy-2-fluoro-α...

Treatment of methyl 4,6-O-benzylidene-3-C-methyl-2-O-p-tolylsulfonyl-α-d-allopyranoside (1) with an excess of sodium methoxide in dry methyl sulfoxide gave a complex mixture from which four crystalline compounds have been isolated: methyl 4,6-O-benzylidene-3-C-methyl-α-d-allopyranoside (2) and...

The crystal structure of methyl 6-O-benzyl-2-deoxy-2-dimethylmaleimido-α-d-allopyranoside was solved in order to gain insight into the hydrogen bond features which can be determining features in the glycosylation regioselectivity observed for this compound. An intramolecular hydrogen bond betwe...

The standard (po = 0.1 MPa) molar energies of combustion, ΔcUmo, for the crystalline 5-isopropylbarbituric and 2-thiobarbituric acids were determined, at the temperature of 298.15 K, by static bomb or rotating bomb combustion calorimetry, respectively. For 5-isopropylbarbituric acid, the standa...

Data taken from published work on the physical properties of substituted barbituric acids show that structure-activity relationships exist for the wetting and for the solubility of these powders. Wetting and solubility results of the powders do not fall in the same rank order; this is demonstrat...

Barbiturates derived by minor structural changes to the butenyl sidechain of the convulsant 5-ethyl-5-(3′-methyl-but-2′-enyl)-barbituric acid are almost devoid of convulsant activity, but all have anaesthetic and anticonvulsant effects. Anticonvulsant activity is also observed in the convulsan...

Screening for NADH-fumarate reductase inhibitors led to the isolation of the new polyketide compounds, ukulactones A and B (1 and 2, Fig. 1) from a culture broth of Penicillium sp. FKI-3389. The structure of ukulactone A was elucidated as a methylated derivative of prugosene A1, which was produc...

BackgroundWe have recently shown neuroprotective activity of the creatine amides in the focal cerebral ischemia in rats on the 280 mg/kg administration. In the present study, neuroprotective properties of creatylglycine ethyl ester fumarate (CrGEt) in rats with focal cerebral ischemia were explo...

Diversity of fumarate reducing (dissimilating) bacteria in the bovine rumen was analyzed by both culture dependent and independent methodologies. A total of 39 strains were isolated by using three different media and belonged to three different phyla (Proteobacteria, Fusobacteria, and Firmicutes...

The objective of this work was to examine the physicochemical properties of spray dried budesonide, formoterol fumarate and their mixtures at two different weight ratios: 100:6 and 400:6 of budesonide and formoterol fumarate, respectively. A comparison of the thermal properties, crystalline/amor...

Metal fumarates are often studied in the context of metal organic framework solids. Preparation, structure and properties of three cobalt(II) fumarates, viz. [Co(fum)(H2O)4]·H2O 1, [Co(fum)(py)2(H2O)2] 2, and [Co(fum)(4-CNpy)2(H2O)2] 3 (fum=fumarate, py=pyridine, 4-CNpy=4-cyanopyridine) are des...

The information of the quenching reaction of bovine serum albumin with dimethyl fumarate is obtained by multi-spectroscopic methods. The number of binding sites, n and binding constants, KA were determined at different temperatures. The effect of increasing temperature on Stern–Volmer quenching...

Dimethyl fumarate (DMF) is widely used to treat the human autoimmune diseases multiple sclerosis (MS) and psoriasis. DMF causes short-term oxidative stress and activates the antioxidant response via the transcription factor Nrf2 but its immunosuppressive effect is not well understood. Immune cel...

In this study, a rapid synthesis of Al fumarate metal-organic framework (AlFu) at 25 °C for 1 minute has been reported. The synthesized AlFu has been impregnated by different amounts of tetraethylenepentamine (TEPA) to build novel CO2 adsorbents. AlFu before and after functionalization was char...

A new fumarato bridged Zn(II) coordination polymer viz. catena[μ-fumaratobis(3,5-dimethylpyrazole)zinc(II)trihydrate],{[Zn2(μ-fum)2(Hdmpz)4]·3H2O}n (1) (where, fum = fumarate, Hdmpz = 3,5-dimethylpyrazole) has been synthesized in purely aqueous medium at room temperature. The compound is stru...

The aim of the present study was to examine the effects of feeding diets with addition of disodium fumarate (DF) to goats on ruminal metabolism and changes of rumen bacterial communities. Four cannulated goats were used in a 4 × 4 Latin square design. The results showed that ruminal pH increase...

The new functionalized hydroxymethylphosphonic and methylenediphosphonic acids are synthesized via unique reaction of tris(trimethylsilyl) phosphite and N-formyl N-heterocycles, N-substituted 4-piperidones, 3-quinuclidone, and 2-adamantanone at the presence of effective catalyst – trimethylsily...

The administration of tritium-labeled 7,12-dimethylbenz(α)anthracene (DMBA) to rats at 24 h after partial hepatectomy resulted in its binding to DNA in small intestine and regenerating liver. The binding in regenerating liver, which began 3 h after i.v. administration of DMBA, reached a maximum...

The foreign H-2-like antigens, abnormally expressed by the BALB/c (H-2d) sarcoma MCG4, were characterized by immunoprecipitation with specific sera and SDS-PAGE (sodium dodecyl sulphate-polyacrylamide gel electrophoresis). These foreign antigens, like normal H-2 antigens, have a structure consis...