A mild and efficient protocol for the selective construction of Z-3-thiocyanatoacrylates is described. Various alkynoates reacted with KSCN and H2O by using cheap and recyclable deep eutectic solvent as the catalyst and reaction media to produce the corresponding products in excellent yields wit...

The n-Propyl Propionate (ProPro) is a compound that has several possible industrial applications. However, the current production route of this component presents several problems, such as the downstream purification. In this way, chromatographic separation could be an alternative solution to th...

The amphiphilic propyl Karaya gum (KG) with a degree of propyl group substitution of 3.24 was synthesized to design self-assembled nanogels as carriers for bosentan monohydrate, a poorly soluble antihypertensive drug. The drug was physically hosted into the hydrophobic core of the micellar nanog...

The n-Propyl Propionate (ProPro) is used as solvents for paints and inks, as well as food and perfume additives, generally considered as one of the best environmental option. However, its reaction system presents a complex Vapor Liquid Equilibrium with four azeotropes. Those previous points moti...

Increased exposure to estrogens and estrogen metabolites is linked with increased rates of breast, ovarian and other human cancers. Metabolism of estrogen can led to formation of electrophilic o-quinones capable of binding to DNA. In order to gain insight into the mechanism of estrogen-induced D...

The low absorptivity of triarylsulfonium salts above 320 nm limits their utilization of longer wavelength emission from light sources. Herein we report the synthesis and photoactivity of anthracene-bound sulfonium salts, in which the sulfonium salt is insulated from the anthracene chromophore by...

The preparation and properties of novel mixed arsonium–iodonium and sulfonium–iodonium ylides are reported. A series of substituted arsonium and sulfonium ylides was obtained by the nucleophilic substitution of iodonium groups in mixed ylides. A one-pot process, which included the nucleophilic...

Thermoresponsive phase behavior of poly(2-chloroethyl vinyl ether-alt-maleic anhydride) (P(CVE-MA)) in mixed solvent of propyl acetate (PrAc) and n-alkane has been investigated. At a proper solvent composition of PrAc/n-octane, the polymer solution was transparent at lower temperature, and becam...

The gas-phase pyrolysis of bis (2-chloroethyl) sulphide (usually named yperite) has been investigated in a static reactor in the following conditions, temperatures ranging from 300 to 500°C, an initial pressure of 16.67 kPa with a dilution in nitrogen and reaction times ranging from 1 to 10 min...

Unsaturated ethers are oxygenated volatile organic compounds (OVOCs) emitted by anthropogenic sources. Potential removal processes in the troposphere are initiated by hydroxyl (OH) radicals and photochemistry. In this work, we report for the first time the rate coefficients of the gas-phase reac...

Ruthenium(II)-arene complexes are promising drug candidates for the therapy of solid tumors. In previous work, seven new compounds of the general formula [Ru(η6-p-cymene)(L1–7)Cl] were synthesized and characterized, of which the complex with L = isoquinoline-3-carboxylic acid (RuT7) was two ti...

A series of racemic 2,2-dimethyl-3-aryl-propanoic acids were resolved by chiral supercritical fluid chromatography (SFC) without the use of an acidic additive, trifluoroacetic acid (TFA). The use of additive-free protic methanol as co-solvent in CO2 was expanded to successfully resolve other ser...

The pharmacological and physicochemical analysis of structurally optimized N-alkyl-substituted indazole-5-carboxamides, developed as potential drug and radioligand candidates for the treatment and diagnosis of Parkinson's disease (PD) and other neurological disorders, is reported. Recent ef...

An automated liquid chromatographic method for the determination of urinary concentrations of 4-hydroxy-3-methoxymandelic acid (VMA) is described. Urine samples are purified by solid-phase extraction on an anion-exchange cartridge and automated on-line chromatographic elution is carried out usin...

The nalidixic acid present in urine after the standard oral dose of 1 g every 6 h has been shown to produce an apparent increase in urinary 4-hydroxy-3-methoxymandelic acid to abnormal levels, when estimated by the method of Pisano et al.5.

An automated method for the determination of urinary 4-hydroxy-3-methoxy-mandelic acid is described. It is based on the procedure of Pisano et al (Clin Chim Acta, 1962; 7: 285–291). The correlation between the automated method and HPLC was high even though diet and medications were not restrict...

A large number of substances have been tested as redox mediators in the LiP-catalysed oxidation of 4-methoxymandelic acid (4-MMA) to anisaldehyde. In some cases (i.e. thioanisole), the mediation efficiency is almost equal to the maximum value displayed by the natural mediator veratryl alcohol. T...

Concentrations of agmatine, coumarylagmatine and the antifungal hordatines in the shoots of barley seedlings have been determined at various stages of growth. Coumarylagmatine declined with age on a fresh weight basis, both in diurnal illumination and in continuous darkness. Hordatines A and B (...

Antifungal hordatines and their precursors, hydroxycinnamoylagmatines, were analyzed in dormant barley seeds and beer sample by ultra-performance liquid chromatography (UPLC) coupled to quadrupole time-of-flight mass spectrometry (QTOF-MS) operating in MSE-mode. Three hordatine basic structures,...

3-(γ-Aminopropyl)-5-ethoxyindole has been synthesized from p-phenetidine and α-methylacetoacetate. This method involves fewer intermediates, with new and better methods for their purification.