Michael addition of 3-tert-butylpyrazole (1) or 3,5-dimethylpyrazole (2) to acrylamide afforded the pyrazolylpropanamide-type ligands 3-(3-tert-pyrazol-1-yl)propanamide (3, = tBuPPA) and 3-(3,5-dimethylpyrazol-1-yl)propanamide (4, = Me2PPA), respectively, in high isolated yields (3: 80%, 4: 76%)...
The use of this material under current use conditions is supported by the existing information.This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as,...
A toxicologic and dermatologic review of linalyl isovalerate when used as a fragrance ingredient is presented.
Triorganotin(IV) derivatives of 2-{[(E)-1-(2-hydroxyaryl)alkylidene]amino}acetic acid have been synthesized and characterized by 1H, 13C, 119Sn-NMR, 119Sn Mössbauer and IR spectroscopic techniques in combination with elemental analyses. The crystal structures of triphenyltin 2-{[(E)-1-(2-hydroxy...
Male C57B1/6N mice, 8–10 weeks old were given a single oral dose of 0, 1.0 or 3.0 mg/kg body weight of trimethyltin hydroxide (TMT). Levels of ornithine decarboxylase (ODC) activity were measured in several brain areas, 1, 2 and 7 days later. The lower dose of TMT produced a decrease of ODC in ...
In this paper, a sequential experimental design is applied to optimize the determination of trimethyltin chloride (TMT) by hydride generation-gas phase molecular absorption spectrometry. The TMT is converted into gaseous trimethyltin hydride by adding a sodium tetrahydroborate (III) solution. Th...
The neurotoxicant trimethyltin (TMT) increases mRNA levels for cytokines, tumor necrosis factor-α, interleukin-1α, and interleukin-6. Cytokines induce matrix metalloproteinases (MMPs) and urokinase-type plasminogen activator (uPA). MMPs and uPA disrupt extracellular matrix. Since matrix damage...
A set of well-defined antisera against neuronal and glial proteins were used to characterize patterns of protein expression in rat hippocampus following transection of the fimbira–fornix and perforant pathways or after administration of the selective neurotoxicant trimethyltin (8 mg/kg, i.p.). ...
Triorganotin(IV) complexes of azo-carboxylic acids derived from amino benzoic acids and resorcinol were synthesized by the reaction of 2/4-(2,4-dihydroxy-phenylazo)-benzoic acids with appropriate triorganotin(IV) chlorides [R = Me (1 and 3), Ph (2 and 4) and Bu (5)] in presence of triethylamine....
A family of 3′-functionalized thymidines carrying XCH2COOH (X = O, NH, S, SO2) groups has been designed as inhibitors of RNase A. This is because it is possible to manipulate the overall acidity of this new class of nucleic ‘acids’ by changing X from oxygen to the SO2 group in the series. It ...
Microglia participates in most acute and chronic neuropathologies and its activation appears to involve interactions with neurons and other glial cells. Trimethyltin (TMT)-induced brain damage is a well-characterized model of neurodegeneration, in which microglial activation occurs before neuron...
Herein we report the synthesis and structural study of ten new tin compounds derived from the polyfunctional and optically active pro-ligand: 2-phenyl-2-(p-tosylsuphonamino)acetic acid (1). Reactions of the sodium carboxylate of compound 1 with SnMe2Cl2; SnPh2Cl2, SnMe3Cl, SnPh3Cl and that of 1 ...
The heats of dilution in water of three isomeric alkylureas (normal-butylurea, tert-butylurea and tetramethylurea) were determined at 25°C. A comparison of the concentration coefficients of the excess enthalpies, with those of other alkylureas in water makes possible to identify, different beha...
1-(1H-Benzimidazol-5-yl)-3-tert-butylurea derivatives have been identified as a novel class of non-peptide luteinizing hormone-releasing hormone (LHRH) antagonists. Herein, we disclose the synthesis and structure–activity relationships (SAR) of this class resulting in the identification of comp...
The crystal field parameters of several enneaaquorare-earth (III) ethylsulfates are interpreted by the angular overlap model, where σ- and π-bonding has been considered.
Magnetic susceptibility measurements on single crystals of dysprosium trifluoromethanesulfonate (DyTFMS) have been carried out from 300 K down to 13 K. The hexagonal crystal structure of DyTFMS renders the crystal uniaxial with the Kramers ion Dy3+ occupying a site of C3h symmetry. The principal...
The adsorption structure and the electronic property of azidotrimethyltin (ATMT) on monolayer graphene were investigated using scanning tunneling microscopy and core-level photoemission spectroscopy. We also confirmed the n-type doping effect by scanning tunneling spectroscopy and work function ...
p-Toluenesulfonyl isocyanate (PTSI) is introduced as electrolyte additive in a bid to enhance the electrochemical performances of LiNi0.5Co0.2Mn0.3O2 cathode materials under high voltage. A less resistive and stable film on the cathode surface derived from PTSI oxidation which taken place prior ...
Zirconacyclopentenes reacted with isocyanates to give aza- or oxazirconacycles which were conveniently coverted into the corresponding haloamidation products of alkynes after halogenation. 1,4-Bistrimethylsilyl substituted zirconacyclopentadiene afforded a low yield of iodoamidation product, whe...
Using HMDS as catalyst for the trimerization of isocyanates presents many advantages as the expected isocyanurate is not contaminated by the catalyst or other side-products resulting from its degradation. In addition, HMDS presents a low toxicity, and is compatible with industrial applications. ...
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