We report an optimized synthesis of aluminum n-hexyloxide (AH), aluminum phenoxide (APh) and aluminum isopropoxide (AIP) with high yields. Aluminum alkoxides, among other applications, are important starting materials to produce high surface area alumina catalyst supports for catalytic applicati...
AlF3 is a strong Lewis acid and several hydrates of it are known, namely the monohydrate, the trihydrate (of which two polymorphs have been described) and the nonohydrate, which forms in the abundance of water, as well as a more complex fluoride of composition Al0.82□0.18F2.46(H2O)0.54 whose st...
Reactions of a slight excess of trialkylaluminum or tri-tert-butylgallium with bis(3-methylindolyl)-2-pyridylmethane (1) produced monomeric, tripodal complexes (2-C5H4N)HC(3-CH3C8H4N)2MR (M = Al, R = Me (2a), Et (2b), iBu (2c), tBu (2d); M = Ga, R = tBu (3)). Under more mild reaction conditions ...
The monomer—dimer equilibria of three liquid aluminum n-alkyls have been studied in n-hexadecane solution by a thermochemical method applied earlier to triethylaluminum (TEA) and triisobutylaluminum (TiBA). The values obtained for the heat and entropy of dissociation of 1 mole of dimer are: for...
Based on a new anchoring strategy, a polymer-supported chiral oxazolidinone was prepared starting from (2R,3S)-3-amino-2-hydroxy-4-phenylbutanoic acid (phenylnorstatine, Pns) and Wang resin. Solid-phase asymmetric alkylation on this resin proceeded in high diastereoselectivity comparable to that...
Analysis by gas chromatography-mass spectrometry (GC-MS) of 24-h cultures of Clostridium butyricum type strain in synthetic BMG medium supplemented with various 2-amino acids (10 mM) revealed the presence of the corresponding 2-hydroxy acids. C. butyricum was able to bioconvert l-valine, dl-norv...
This paper describes enzymatic procedures for the synthesis of (S)-2-amino-4-phenylbutanoic acid ((S)-APBA) and (R)-2-hydroxy-4-phenylbutanoic acid ((R)-HPBA), building blocks of angiotensin converting enzyme inhibitors. 2-Oxo-4-phenylbutanoic acid was converted to (S)-APBA and (R)-HPBA catalyze...
We report herein the design and synthesis of a series of novel 5-halogenated-7-azaindolin-2-one derivatives containing a 2,4-dimethylpyrrole moiety. Nine target compounds with ⩾70% inhibition against MCF-7 at 30 μM were further evaluated for their in vitro antitumor activity against seven human...
The rhodium-catalyzed reactions of 3-diazoindolin-2-imines with β-enamino esters furnished 2,3-diaminoindoles in excellent yields with wide functional group tolerance. The synthesized 2,3-diaminoindoles could be converted into 5H-pyrazino [2,3-b]indoles via a sequential dehydrogenation/6π-ERC/...
GPR54 is a G protein-coupled receptor (GPCR) which was formerly an orphan receptor. Recent functional study of GPR54 revealed that the receptor has an essential role to modulate sex-hormones including GnRH. Though antagonists of GPR54 are expected to be novel drugs for sex-hormone dependent dise...
GPR54 is a G protein-coupled receptor (GPCR) which was formerly an orphan receptor. Recent functional study of GPR54 revealed that the receptor plays an essential role to modulate sex-hormones including GnRH. Thus, antagonists of GPR54 are expected to be novel drugs for sex-hormone dependent dis...
The syntheses and characterizations of two new amine oxime ligands are described. In addition, the crystal structure of the dihydrochloride salt of the previously reported 2-[N-(4-aminobenzyl)amino-3-methyl-2-butanone oxime (aminobenzAO) is reported. This structure features a three-dimensional n...
2-(2′-Hydroxyphenyl)benzimidazole derivatives (X-HBIs), modified by various substituents X (X=H, CH3, OH, OCH3, NO2, NHCOCH3, NH2, N(CH3)2), were synthesized and their fluorescent behaviors and equilibriums in aqueous solution were studied. Strong fluorescence attributed to the tautomer emissio...
This chapter covers recent progress in the synthesis of benzimidazol-2-ones (1,3-dihydro-2H-benzimidazol-2-ones) via rearrangements of various heterocyclic systems such as benzodiazepin(di)ones, quinoxalin(on)es, tetrazolones, condensed and spiro compounds with a benzimidazole system, and anthra...
SummaryA series of 2-(4-aminophenyl)-N,N-dipropylethylamine derivatives were synthesized and tested for in vivo intrinsic activity at brain dopamine receptors in the rat. Differences in the sensitivity of dopamine receptors pre- and post-synaptically in the reserpine-treated rat were used to est...
Six amino acid derivatives of 1-(4-aminophenyl)-2-aminopropanes and their parent amines were synthezised and tested for their potency and selectivity in inhibiting monoamine oxidase (MAO) in vitro and in vivo. The amino acid derivatives were 300–1000 times less potent than the parent amines in ...
A new synthetic pathway to 1-(2-[β,d-galactopyranosyloxy]ethyl)-7-(1-carboxy-3-[4-aminophenyl]propyl)-4,10-bis(carboxymethyl)-1,4,7,10-tetraazacyclododecane (Gal-PA-DO3A-NH2) and 1-(2-[β,d-galactopyranosyloxy]ethyl)-4,7,10-tris(carboxymethyl)-1, 4,7,10-tetraazacyclododecane (Gal-DO3A) chelatin...
A selective chiral high performance liquid chromatographic (HPLC) method was developed and validated to separate and quantify the enantiomers of a novel anticonvulsant agent, N-(4-chlorophenyl)-1-(4-pyridyl)ethylamine (AAP-Cl), in rat plasma. After extraction of the plasma samples with ethyl ace...
Five new compounds, 6–10, derivatives of mesoionic 3-phenylo-1,2,3,4-thiatriazolium-5-aminide, have been obtained. The structures of the compounds have been investigated by 1H, 13C, 15N NMR and X-ray diffraction. The 15N NMR technique has been used for identification of a heteroatomic backbone ...
Five derivatives of mesoionic 1,2,3,4-thiatriazolo-5-aminide and its salts were synthesized. The structures of the compounds were examined by 1H, 13C, 14N and 15N NMR techniques. The protonation of the compounds occurs on the nitrogen atoms of the exocyclic group; one or two molecules of acid ar...
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View