A new scheme for synthesis of saturated 1-O-alkyl-2-O-methyl-rac-glycerolipids is described. The reductive cleavage of 2-O-methyl-1,3-O,O-benzylideneglycerol with BH3 · THF complex leads to 1-O-benzyl-2-O-methyl-rac-glycerol, which is a key intermediate for the facile preparation of 1-O-alkyl-2...
We present a tetrahydrocarbozole-forming carbo-trifluoromethylation of indoles bearing an alkenyl group at the C3 position. The reaction proceeded selectively with the combination of TsOH·H2O as a catalyst and CH2Cl2 as a solvent. The site-selectivity could be altered by changing the reaction s...
Comparison of several amine-substituted and methoxy-substituted analogs of N1-(4-aminobenzene)sulfonylindole suggests that these substituents might contribute to the 5-HT6 serotonin receptor affinity of these agents via their electronic effect on the indolic nucleus. Their 1,2,3,4-tetrahydrocarb...
Oral administration of a single dose of cyanofenphos (O-ethyl O-4-cyano-phenyl phenylphosphonothioate) between 10 and 500 mg/kg, caused delayed neurotoxocity in hens similar to that reported for other organophosphorus esters. The severity of the clinical condition depended upon the size of the a...
Publisher SummaryThis chapter provides the basic synthesis paths routes for the manufacture of cyanofenphos, with a listing of the main raw materials and intermediates used in the synthesis of cyanofenphos. Cyanofenphos is commercially known as Surecide and it belongs to the phosphonothioate group.
Mixtures of 2-ethylhexylsodium and 2-ethylhexyllithium are studied by 1H- and 13C-NMR spectroscopy in the temperature range from 20 to −50°C in hydrocarbon solutions. Characteristic temperature-dependent spectra obtained are indicative of dynamic exchange processes taking place in the system. T...
Premature senescence, a death escaping pathway for cells experiencing stress, is conducive to aging and cardiovascular diseases. The molecular switch between senescent and apoptotic fate remains, however, poorly recognized. Nrf2 is an important transcription factor orchestrating adaptive respons...
Novel nanoporous composites (MIL/K-SO3H and MIL/Ks-CN) were synthesized by the encapsulation of para-sulfonatocalix[4]arene (K-SO3H) and para-tert-butylthiacalix[4]arene (Ks-CN) with strong (SO3H) and weak (CN) acidic functionalities, respectively, in the aluminum(III) 2-aminoterephthalate metal...
Uninorms continuous on [0, e[2 ∪ ]e, 1]2 are discussed. Archimedean uninorms continuous and cancellative on ]0, e[2 ∪ ]e, 1[2 are characterized and related non-Archimedean uninorms are also discussed. The problem when is the border-continuous projection of a t-norm associative, i.e., a t-subno...
The solubility of 5,10,15,20-tetrakis(4-chlorophenyl) porphyrin manganese(III) chloride (abbreviated in p-ClTPPMnCl) in N,N-dimethylformamide (abbreviated in DMF) + water solvent mixtures at 293.2–353.2 K were measured. The effects of mass fraction of DMF in the solvent mixtures at 1.00–0.80 o...
Industrial citric acid (CA) production started nearly 100 years ago. CA production is a well-established bioprocess that employs parental or mutant strains of the fungus Aspergillus niger. CA production continues to rise because it exhibits versatility for many applications, primarily in the foo...
Three different series of xylosylated naphthoic acid–amino acid conjugates containing one or two amino acid residues were synthesized for the investigation of glycosaminoglycan priming and potential use as anti-tumor drugs. All xylosylated naphthoic acid-conjugates inhibited the growth of norma...
A limitation in the systemic uptake of many inhalable drugs is the restricted permeation through the pulmonary epithelial layer barrier. One strategy to bypass the epithelial layer when delivering non-permeable drugs is to alter the paracellular transport, allowing the uptake of drugs into the s...
Awamori is a traditional distilled liquor in the Ryukyu Islands, made from steamed rice by the action of the black-koji mold Aspergillus luchuensis and awamori yeast Saccharomyces cerevisiae. One of the specific flavors in aged awamori kusu is vanillin, which is derived from ferulic acid (FA) in...
The 2-diethylaminoethyl ester of 3-hydroxy-2-naphthoic acid was nitrated in acetic acid solution to yield the corresponding ring-substituted 4-nitro derivative. Catalytic hydrogenation of the nitro compound gave 2-diethylaminoethyl 4-amino-3-hydroxy-2-naphthoate hydrochloride. The anesthetic pro...
Skin loss presents an ongoing challenge in reconstructive surgery. Approaches to achieve tension-free closure of these defects include autologous skin flaps, alloplastic and xenogenic implants. However, these approaches have disadvantages, including donor-site morbidity, infections and immunolog...
Wheat gluten films were cast from aqueous dispersions containing 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) and N-hydroxysuccinimide (NHS) as cross-linking reagents and glycerol as a plasticizer. Cross-linking was carried out to improve film properties such as water sensitivity and ten...
The synthesis of novel N,N′,N″-tris(3-dimethylaminopropyl)-guanidine 1 is described and X-ray structure of its hexafluorophosphate salt measured (1H·PF6). The hydrogen bonding in protonated 1 and in 1H·PF6 is also discussed.
Gellan gum (GG) is an exopolysaccharide produced by Sphingomonas elodea. To develop a medical application for GG, in this study we prepared 26 μm thick films of GG reacted with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) in 40% ethanol to obtain a cross-linked film (GG40) with 73% gel c...
Recent advancements in polymeric gene delivery have raised the potential of gene therapy as treatment for various acquired and inherited diseases. Here, we report on the synthesis and characterization of N-ethyl-N’-(3-dimethylaminopropyl)-guanidinyl-polyethylenimine (sGP) polymers and investiga...
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