Hyperammonemia and jaundice are the most common clinical symptoms of hepatic failure. Decreasing the level of ammonia in the blood is often accompanied by a reduction in bilirubin in patients with hepatic failure. Previous studies have shown that hyperammonemia can cause bilirubin metabolism dis...
BiLirubin dimethyl ester (1) has been studied by fluorescence and fluorescence excitation and by solvent-induced circular dichroism. The existence of two or more forms of the solute involving either or both syn-anti dipyrromethenone and lactamlactim equilibria, was established. The relative popu...
New bilirubin congeners (1a–1d) with the central C(10) CH2 replaced by C(CH3)2 were smoothly synthesized by coupling two identical dipyrrinones with 2,2-dimethoxypropane under acid catalysis. The new yellow pigments, with acid chains varying from acetic (n=1) to propionic (n=2) to butyric (n=3)...
The dimethyl ester and bis-N,N-dimethylamide of an optically active analog of bilirubin (ßS,ß′S-dimethylmesobilirubin-XIIIα) is stabilized in a ridge-tile conformation by intramolecular hydrogen bonding, as detected by 1H-NMR and CD spectroscopy. The ridge-tile shape is most evident in nonpola...
The ever-increasing demand for a sensitive, rapid and reliable method for determination of serum bilirubin level has been inciting the interest of the researchers to develop new methods for both laboratory set up and point of care applications. These efforts embrace measurement of different form...
A spectral study of bilirubin and bilirubin dimethyl ester complexes with a variety of metal ions indicates that bilirubin forms two different types of complexes, interacting either with the pyrrole nitrogens or with the propionic acid side chains. A combination of the two types is possible. The...
Overproduction of arachidonic acid (AA) mediated by secretory phospholipase A2 group IIA (sPLA2IIA) is a hallmark of many inflammatory disorders. AA is subsequently converted into pro-inflammatory eicosanoids through 5-lipoxygenase (5-LOX) and cyclooxygenase-1/2 (COX-1/2) activities. Hence, inhi...
Photo-active trans-3-(4-pyridyl)acrylic acid (PYA) modified chitosan (CSPA) was synthesized with different functionalization degrees and extensively examined using Fourier transform infrared spectra (FTIR), 1H and 13C nuclear magnetic resonance (NMR) in order to elucidate the chemical structure ...
Aiming at the most enhancing the catalytic performance of simple and cheap cobalt(II) 5,10,15,20-tetrakis(4-pyridyl)porphyrin (Co TPyP), guided by the nowadays-advanced various technologies, Co TPyP was anchored onto nanoporous bar with thiol-functionalized silica (npb-SiO2-SH). The resulting np...
A series of 5-substituted 3-isopropyl-7-[4-(2-pyridyl)benzyl]amino-1(2)H-pyrazolo[4,3-d]pyrimidine derivatives was synthesized and evaluated for their cyclin-dependent kinase (CDK) inhibition activity. The most potent compounds contained various hydroxyalkylamines at the 5 position and possessed...
New mixed ligand complexes [Ni(aptt)2(en)2] (1), [Ni(apytt)2(en)2]⋅CHCl3 (2) and [Ni(athtt)2(en)2] (3) with 4-amino-5-phenyl-2H-1,2,4-triazole-3-thione (Haptt), 4-amino-5-(pyridin-3-yl)-4,5-dihydro-3H-1,2,4-triazole-3-thione (Hapytt) and 4-amino-5-thiophen-2H-1,2,4-triazole-3-thione (Hathtt) hav...
To get new anti-hepatoma agents with anti-inflammatory activity and hypotoxicity, a series of dissymmetric pyridyl-substituted 3,5-bis(arylidene)-4-piperidones (BAPs, 25–82) were designed and synthesized. Many of them exhibited potential anti-hepatoma properties against human hepatocellular car...
Crystal structures of [UO2(crt)2(bpe)2] (I) and (H2bpe)2(OH)2[UO2(crt)3]2[UO2(crt)2(H2O)2] (II), where crt = crotonate ion C3H5COO– and bpe = trans-1,2-bis(4-pyridyl)ethylene C12H10N2, were solved via single crystal X-ray diffraction analysis and characterized via FTIR spectroscopy. Even though...
Platinum(II) and platinum(IV) complexes with 3-amino-5-methyl-5-(4-pyridyl)-2,4-imidazolidenedione (L) with general formulaе cis-[PtL2X2]·nH2O and [PtL2Cl4], where X = Cl−, Br−, I− and n = 2–4) were synthesized. The novel compounds were fully characterized by elemental analysis, IR, 1H, 13C, ...
Publisher SummaryStudies on chemical carcinogenesis have three main purposes. First is to elucidate carcinogenic mechanisms, second is to prevent possible carcinogenic hazard due to chemicals in the environment, and third is to provide clinical model systems in experimental animals. Recent studi...
Transformation of 14 quinolines polyfluorinated in the benzene moiety was investigated in nitration systems: a mixture of HNO3 and H2SO4, NaNO3 in H2SO4, NO2BF3OH in sulfolane, or NaNO3 in oleum. 5-Nitro- and/or 8-nitro derivatives formed if positions 5 or 8 were unoccupied in the starting compo...
In this paper, we disclose the design and synthesis of a series of 2-substituted pyrrolidine-2-yl-acetic acid as core structures and the N-arylalkyl derivatives thereof as potential GABA transport inhibitors. The 2-position in the side chain of pyrrolidine-2-yl-acetic acid derivatives was substi...
Crosslinked polymer particles carrying hemilabile bis-N,N-aminophosphine (PNP) moieties are obtained by the copolymerization of a PNP-derived monomer bearing four vinyl fragments as cross-linkers, with para-tert-butylstyrene and divinylbenzene, using free radical copolymerization in presence of ...
The molecular characteristics of poly(4-tert-butoxystyrene) (O) upon hydrolysis reaction were investigated. It is known that O can be converted into poly(4-hydroxystyrene) (H) through hydrolysis reaction using strong acid. In this study, a set of poly(4-tert-butoxystyrene-co-4-hydroxystyrene)s (...
Fatty acid methyl esters (FAME) derived from lipids of microalgae is known to have wide bio-functional materials including antimicrobials. FAME is an ideal super-curator and superior anti-pathogenic. The present study evaluated the efficiency of FAME extracted from microalgae Scenedesmus interme...
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