α-Iso-cubebene, a natural compound isolated from Schisandra chinensis fruit, strongly enhanced survival rate in cecal ligation and puncture (CLP) challenge-induced sepsis. The mechanism involved the marked reduction of viable bacteria in the peritoneal fluid, by virtue of increased phagocytic a...
Poly (2‑hydroxyethyl methacrylate) (PHEMA) was crosslinked in the presence of biocompatible and biodegradable poly(caprolactone) (PCL) based polyurethanes (PUs) and cellulose nanowhiskers (CNWs). The CNWs were obtained from wastepaper. In order to crosslink PHEMA (10 wt%), a novel acrylic-uretha...
A new acceptor polypyridinic ligand functionalized with a quinone fragment is reported. The ligand, dipyrido[3,2-a:2′,3′-c]-benzo[3,4]-phenazine-11,16-quinone, Nqphen, was synthesized by condensation of 1,10-phenanthroline-5,6-dione and 2,3-diamino-1,4-naphthoquinone. The syntheses of two rhen...
ResumeNous avons dans un essai en double aveugle randomisé, comparé le xibornol, la tétracycline et un placebo chez 68 malades qui présentaient une infection saisonnière des voies aériennes supérieures sans un caractère patent de gravité. Les malades ont été répartis en trois groupes...
Xibornol is a lipophilic drug mainly used in Italy and Spain in spray dosage forms for the local treatment of infection and inflammation of the throat. Its poor water solubility makes difficult the development of aqueous formulations of the drug, thus giving rise to a limited number of stable an...
The criteria for the activity of 2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid (XK469) and 2-{4-[(7-bromo-2-quinolinyl)oxy]phenoxy}propionic acid (SH80) against transplanted tumors in mice established in previous studies, require a (7-halo-2-quinoxalinoxy)- or a (7-halo-2-quinolinoxy...
SummaryPeriodic observations on soil respiration revealed that the application of MCPB had inhibitory effect on oxygen consumption, particularly at low concentrations. The application of farm yard manure (FYM) proved not only stimulatory, but it also counteracted the toxic effect of MCPB. Disyst...
In this study, commercial activated carbons (GAB and CBP) were successfully used for the removal of two phenoxy acetic class-herbicides, 4-chloro-2-methyl phenoxy acetic acid and 2.4-dichlorophenoxy acetic acid (MCPA and 2.4-D) from aqueous solution. The adsorbent materials were characterized, a...
We report herein the synthesis and evaluation of a series of β-d-2′-deoxy-2′-α-chloro-2′-β-fluoro and β-d-2′-deoxy-2′-α-bromo-2′-β-fluoro nucleosides along with their corresponding phosphoramidate prodrugs. Key intermediates, lactols 11 and 12, were obtained by a diastereoselective f...
The objective of this study is to investigate the use of coffee waste (CW) to remove the 4-chloro-2-methyl phenoxy acetic acid (MCPA) from aqueous solutions. To prepare CW, it was first washed and boiled to remove color and impurities then it was air dried at room temperature for 48 h. Afterward...
In the present study 18 novel imidazole-(benz)azole and imidazole–piperazine derivatives were synthesized in order to investigate their probable anticancer activity. The structures of the compounds were confirmed by IR, 1H NMR and EI-MS spectral data. Cytotoxicity (MTT), analysis of DNA synthes...
The chiral inversion properties of 4-(4-methylphenyl)-2-methylthiomethyl-4-oxobutanoic acid (KE-748), an active metabolite of 2-acetylthiomethyl-4-(4-methylphenyl)-4-oxobutanoic acid (KE-298), were compared with those of ibuprofen in rats. After administration of R(−)-[2α-2H]KE-748, S(+)-KE-748...
BackgroundOsteoarthritis (OA) as the main chronic joint disease arises from a disturbed balance between anabolic and catabolic processes leading to destructions of articular cartilage of the joints. While mechanical stress can be disastrous for the metabolism of chondrocytes, mechanical stimulat...
This research aimed towards the design of preparations of diacerein loaded cholesterol rich niosomes by employing a 3-factor, 3-level Box-Behnken design. Results indicated that Span 60 (90 mg) and cholesterol (10 mg), and 45 min of hydration time were found to be optimum for niosomes preparation...
BackgroundEpidermolysis bullosa simplex (EBS) is a rare genetic, blistering skin disease for which there is no cure. Treatments that address the pathophysiology of EBS are needed.
A link between inflammation with obesity and metabolic syndrome has been found in patients with chronic kidney disease (CKD). Diacerein is an anthraquinone used to treat osteoarthritis that exerts anti-inflammatory action by inhibiting the synthesis and activity of proinflammatory cytokines. Thi...
A novel spectrophotometric method named constant absorbance pattern technique was proposed for simple determination of binary mixtures exemplified by diacerein, a treatment of osteoarthritis, and rhein, diacerein main alkaline degradation product and active metabolite. The proposed novel constan...
Cervical hyperkeratosis is a common gynecological lesion and usually caused by inflammation or trauma. We investigated the effect of Diacerein on Estradiol benzoate-induced cervical hyperkeratosis. Diacerein (50 mg/kg/day) was given orally to rats for 4 weeks in the presence or absence of cervic...
BackgroundProgression of osteoarthritis (OA) is characterized by an excessive production of matrix degrading enzymes and insufficient matrix repair. Despite of active research in this area, it is still unclear how the combination of mechanical exposure and drug therapy works. This study was done...
Necroptosis is suggested to have an important role in the pathogenesis of rhabdomyolysis induced acute kidney injury (AKI). In this study, the renoprotective effect of diacerein on glycerol-induced AKI was investigated. Twenty four male albino rats were included in this study and divided into fo...
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