The inverse relationship between osteoblast and adipocyte differentiation in bone marrow mesenchymal stem cells has been linked to overall bone mass. It has previously been reported that conjugated linoleic acid (CLA) inhibits adipogenesis via a peroxisome-proliferator activated receptor-γ (PPA...
NMR data on lipid hydroperoxides is scarce. In this study, hydroperoxides were produced from methyl 9-cis,11-trans-octadecadienoate and from methyl 10-trans,12-cis-octadecadienoate by autoxidation in the presence of 20% of α-tocopherol. Ten different hydroperoxides were isolated from the autoxi...
Biomedical studies with animal models have demonstrated that cis-9, trans-11 conjugated linoleic acid (CLA), the predominant isomer found in milk fat from dairy cows, has anticarcinogenic effects. We recently demonstrated endogenous synthesis of cis-9, trans-11 CLA from ruminally derived trans-1...
A method for purification of cis-9,trans-11 isomer of conjugated linoleic acid (CLA) is described. Lipase from Candida cylindracea (CCL) was highly selective towards cis-9,trans-11 isomer and was chosen to catalyze esterification of a mixture of two CLA isomers. The effect of various parameters ...
Mixtures of the two major conjugated linoleic acid (CLA) isomers trans-10,cis-12-CLA and cis-9,trans-11-CLA are used as over the counter supplements for weight loss. Because of the reported adverse effects of CLA on insulin sensitivity in some mouse studies, we sought to compare the impact of di...
Compounds 7′ and 6′-bromo-d-tryptophan (1 and 2) which are important derivatives for the synthesis of the chloropeptin and kistamycin A, respectively, were conveniently synthesized by optical resolution from N-acetyl-7′ and 6′-bromo-dl-tryptophan ((RS)-5 and (RS)-14) using d-aminoacylase.
The irradiation of methyl geranate (3) in ether using 254 nm lamps produces methyl 5-methyl-2-isopropenyl-4-hexenoate (13), 1,6,6-trimethyl-endo-5-carbomethoxybicyclo-[2.1.1]hexane (11), methyl 2-isopropenyl-5-methylcyclopentanecarboxylate (12) and methyl (3Z)-3,7-dimethyl-3,6-octadlenoate (14)....
The photochemical transformations of methyl geranate are analyzed in terms of the dependence of quantum yield upon base, 1,2-dimethylimidazole, concentration. The dependence of quantum yield of deconjugated esters methyl (3Z)-3,7-dimethy1-3,6-octadienoate (12), methyl 3-methy1ene-7-methyl-6-octe...
To investigate the biotransformation pathway of airborne geraniol by Achyranthes bidentata (A. bidentata), deuterium labeled geraniol was applied with or without methyl jasmonate (MeJA), and the biosynthesized metabolites were analyzed. In A. bidentata leaves, geraniol was conjugated with glucos...
Publisher SummaryThis chapter describes the synthesis of an affinity column for farnesylpyrophosphate synthetase based on the geranyl moiety and a rapid purification of the enzyme from avian liver and yeast. Farnesylpyrophosphate synthetase is a 1'-4 prenyltransferase that produces a key in...
With the help of easily obtainable N-acylaspartic acids, the 4-phenylcinnamoyl and the 4-benzyloxycinnamoyl moiety were identified as structurally simple, readily available farnesyl surrogates, yielding more potent inhibitors of farnesyltransferase than the literature known N-farnesoylaspartic acid.
The RhoA/Rho-kinase (ROCK) pathway is involved in angiotensin (Ang) II-induced cardiac hypertrophy. However, it is still unclear whether inhibition of farnesylpyrophosphate (FPP) synthase can attenuate Ang II-induced hypertrophic responses, and whether it involves the RhoA/ROCK pathway. The anti...
The Rho guanosine triphosphatases (Rho GTPases) family, including RhoA, plays an important role in angiotensin II (Ang II)-mediated cardiac hypertrophy. Farnesylpyrophosphate synthase (FPPS)-catalyzed isoprenoid intermediates are vital for activation of RhoA. The present study was designed to in...
During the study of the temporal changes of benzylpenicillenic acid in aqueous buffers using differential pulse polarography, penicillamine was found to be a degradation product at neutral pH. Since this result was not previously reported, the effects of pH and buffer concentration on penicillam...
The differential pulse and direct current polarographic behaviour of benzylpenicilloic acid (BPA) is discussed. In pH 9.2 borate buffer, the single anodic wave (E12 = -0.25 V) obtained is diffusion-controlled at concentrations less than 2 × 10-5 M but adsorptioncontrolled in 10-4 M solution. Cy...
A generic enzyme immunoassay (EIA) for penicillins containing the intact penam nucleus (PEN EIA), and an EIA for penicillin G derivative after alkaline hydrolysis of the betalactam ring (benzylpenicilloic acid, BPO EIA) were used to analyse raw goat milk. The detection limit for penicillin G in ...
□ 5R,6R -Benzylpenicilloic acid was found to epimerize slowly in alkaline media to 5S,6R-benzylpenicilloic acid until equilibrium was established. Epimerization proceeded via the imine tautomer of penamaldic acid rather than the enamine form and was found to favor the 5S,6R-epimer at equilibriu...
Benzylpenicilloic acid (BPNLA) is a major cleavage product of benzylpenicillin G (BP) generated after heating treatment. It is found in animal derived products from the unstable residual penicillin. Previous studies have only reported the allergic reaction caused by BPNLA, but not described its ...
We describe the evolution of stable azomethine ylid precursors which avoid the need for an aldehyde in the ylid generation step. tert-Butyl carbamate derivative (16) demonstrates comparable efficiency to the standard method of ylid generation and trapping, but permits use of milder conditions.
Two solutions in ethyl acetate (EA) containing 3 wt% trichloroisocyanuric acid (TCI) from two different suppliers having different active chlorine contents were used as chemical surface treatment of a vulcanized styrene–butadiene (SBR) rubber. The amount of active chlorine in the TCI solutions ...
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