The analytical behavior of uramyldiacetic acid as potential chromogenic reagent for the spectrophotometric determination of trace materials is studied. As a result, interesting reactions with copper (II), uranium (VI), iron (II), iron (III), cobalt (II), cerium (II), and nickel (II) in neutral o...
The assimilation of sulfur amino acid derivatives by Candida utilis and by Saccharomyces cerevisiae have been studied. The culture supplements included d-methionine, d- and l-homocysteine, dl-2-hydroxy-4-methylmercaptobutyric acid, dl-N-acetylmethionine, dl-alanyl-dl-methionine, dl-2-amino-4-(me...
A number of choline and ethanolamine analogs were evaluated as inhibitors of P. falciparum growth in vitro. 1-Aziridineethanol, DL-2-amino-1,3-propranediol and D- or L-2-amino-1-butanol were the most efficient inhibitors of parasite multiplication, with an IC50 of 50–80 μM, whereas numerous ot...
The enantiomeric resolution by fused-silica capillary gas—liquid chromatography (GLC) of non-protein dl-α-amino acids of the structure H2NCR1R2COOH (R1 = alkyl, R2 = alkyl, alkaryl) was investigated by using chiral [l-valine-tert.-butylamide, linked to a statistical polymer of dimethylsiloxane...
The preparation and photophysics of organometallic Ir(III) complexes with 3-phenylpyridazine (H6Clppdz) and its derivative are reported. IrCl3 · nH2O reacts with H6Clppdz, and 3-chloro-6-(3′-methoxyphenyl)-4-methyl-pyridazine (MCOMppdz) to give the corresponding chloride-bridged dimers, (6Clpp...
Upon a formation of complexes of EGCg and cyclo(l-Pro-Gly), cyclo(d-Pro-Gly) in D2O, a chirality of cyclo(Pro-Gly) was recognized by difference of the chemical shift of 1H NMR signal for H7α, H7β,8α of the Pro residue. Judging from the crystal structures of the 2:2 complexes of EGCg and cyclo...
l-Amino acid ligase (Lal) catalyzes dipeptide synthesis from unprotected l-amino acids by hydrolysis ATP to ADP. Each Lal displays unique substrate specificity, and many different dipeptides can be synthesized by selecting suitable Lal. We have already successfully synthesized Met–Gly selective...
The adsorption of GLY-PRO-GLU tripeptide on Au(110) is investigated within the frame of all atom classical mechanics simulations and Density Functional Theory, focusing on the surface reconstruction. It is shown that the tripeptide adsorption reorganizes and restructures the Au(110) surface. A m...
In this study, effects of LA-GPE (R-α-Lipoyl-Gly-l-Pro-l-Glu dimethyl ester) and GPE (Gly-L-Pro-L-Glu) on the cytotoxic action of Aβ1–42 were tested with differentiated human neuroblastoma SH-SY5Y cells as cellular Alzheimer model via measurements of mitochondrial viability (MTT assay) and la...
BackgroundProline–glycine–proline (PGP) is a bioactive fragment of collagen generated by the action of matrix metalloproteinase-9 (MMP-9) and prolylendopeptidase (PE), and capable of eliciting neutrophil chemotaxis and epithelial remodelling. PGP is normally then degraded by leukotriene A4 hyd...
In this work, a label-free electrochemiluminescence (ECL) immunosensor was constructed for the sensitive detection of a heart failure biomarker, N-terminal pro-B-type natriuretic peptide (NT-proBNP). Graphite-phase carbon nitride nanosheets (g-C3N4 NS) loaded on cerium-metal organic frameworks (...
Rambutan peel phenolics (RPP) have high antioxidant and anti-inflammatory activities. Leu-Ser-Gly-Tyr-Gly-Pro (LSGYGP) possesses good radical scavenging activity and matrix metalloproteinase (MMPs) inhibitory ability. These underlying mechanisms indicated that RPP and LSGYGP may be used for anti...
This study investigated the anti-inflammatory effects of novel pseudotripeptides (GPE 1–3) as potential candidates to counteract neuroinflammation processes in Alzheimer’s disease.GPE 1–3 pseudotripeptides are synthetic derivatives of Gly-l-Pro-l-Glu (GPE), the N-terminal tripeptide of IGF-1,...
BackgroundIncreased body fat may be associated with an increased risk of developing an underlying pro-inflammatory state, thus leading to greater risk of developing certain chronic conditions. Immunoglobulin G has the ability to exert both anti- and pro-inflammatory effects, and the N-glycosylat...
In this study; the experimental (NMR, infrared and Raman) and theoretical (HF and DFT) analysis of dinicotinic acid were presented. 1H and 13C NMR spectra were recorded in DMSO solution and chemical shifts were calculated by using the gauge-invariant atomic orbital (GIAO) method. The vibrational...
A mild procedure of palladium and copper catalyzed decarboxylative cross-coupling reaction of aryl halides and alkynyl carboxylic acids has been developed. Low molecular weight acids, to introduce small building blocks, were specifically used. This methodology is easy to implement and uses commo...
A decarboxylative coupling reaction with an alkynyl carboxylic acid and aryl iodides in the presence of a nickel catalyst was developed. When the reaction was conducted with NiCl2 (10 mol%), Xantphos (15 mol%), Mn (1.0 equiv), and Cs2CO3 (1.5 equiv), the desired diaryl alkynes were formed in mod...
The high resolution crystal structure of 5-(2-thienylacetamido)-1,3,4-thiadiazole-2-sulfonamide complexed to human (h) carbonic anhydrase (CA, EC 4.2.1.1) isoform hCA II is reported. The compound binds in a similar manner with acetazolamide when the sulfamoyl–thiadiazolyl–acetamido fragment of...
Twenty derivatives of 2,6-disubstituted 4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide and ten of 2-substituted 4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxamide were synthesized by molecular modification of a known antimycobacterial molecule. Compounds were evaluated in vitro agai...
A colorimetric and fluorimetric fluorescent chemosensor (CT-2), having a coumarin ring as a signaling unit and an acetamido thiophene ring as an H-donor receptor, has been synthesized from amino derivative (CT-1) of CT-2 for the purpose of recognition of anions in DMSO. The absorption and emissi...
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