Reaction of 1-(2-chloro-5-nitrophenyl)ethanone via Willgerodt–Kindler route with primary or secondary amines and sulfur allows a simple, efficient one-pot synthesis of 3-aminobenzo[b]thiophenes. Base-catalyzed transformation of 4-(2-chloro-5-nitrophenyl)-1,2,3-thiadiazole in the presence of pri...
This chapter records the progress in mapping the reactivity of thiophenes, benzothiophenes, and dibenzothiophene since 1996. The three major areas of focus are (1) the design and synthesis of dithienylethene molecules for application as photochromic systems; (2) reactions of thiophenes brought a...
Reacting with nickel(II) chloride, copper(II) chloride and bromide, thiophene-2,3-dicarboxaldehyde bis(oxime) (2,3BTCOH2) leads to metal complexes formulated as [NiCl2(2,3BTCOH2)], [CuCl2(2,3BTCOH2)] and [CuBr(2,3BTCOH)]2 respectively. In the case of nickel(II) bromide, we have observed the rear...
New thiophene (2–13) and thienopyrimidine (15–27) derivatives have been synthesized. Twenty three compounds were screened against five cell lines namely; hepatocellular carcinoma (liver) HepG-2, epidermoid carcinoma (larynx) Hep-2, mammary gland (breast) MCF-7, human prostate cancer PC-3 and e...
The Schiff base of the title has been synthesized and its crystal structure determined by single-crystal X-ray diffraction. The compound was characterized by IR, Raman, 1H NMR, 13C NMR and electronic absorption spectra. DFT calculations provide the quantum chemical basis for the observed molecul...
An integrated microchip was presented for selective recognition of Z-l-Phe-OH-NBD, using molecular imprinting technique. Molecularly imprinted polymer (MIP) were prepared by copolymerization in the presence of template molecule Z-l-Phe-OH-NBD, in which methacrylic acid and 4-vinylpyridine were u...
The coupling reaction of diphenylphosphine sulfide with N,N-disubstituted formamides in the presence of an excess amount of sodium hydride proceeded smoothly to give the corresponding aminomethyldiphenylphosphine sulfides in good yields. This method is expected to provide a useful synthesis of P...
Urine samples from mice which had received N,N-dimethylformamide were investigated by high field 1H-NMR spectroscopy. The most prominent signals in the N-CH3 region had chemical shifts identical with those of N,N-dimethylformamide ( δ 2.85, 3.01) and N- (hydroxymethyl)-N-methylformamide ( δ 2....
N,N-dimethylformamide (DMF) is a versatile solvent with wide industrial applications. Evidences from animal studies and occupational poisoning cases have clearly demonstrated that DMF exposure can lead to different degrees of liver damage. It is noteworthy that DMF below the threshold limit valu...
This study has explored the potential energy surface on the chemical reaction of CH2OH with NO by using ab initio calculation. We have found the new reaction pathway producing N-hydroxy formamide, which can further decompose to generate isocyanic acid as a reducing agent of hydrocarbons selectiv...
Formamide provides the raw material and the reaction leads connecting hydrogen cyanide HCN chemistry with higher complexity molecular structures. Formamide is liquid between 4 and 210 °C and, upon heating in the presence of one of several catalysts, affords nucleic bases, acyclonucleosides, car...
The complexity of life boils down to the definition: “self-sustained chemical system capable of undergoing Darwinian evolution” (Joyce, 1994) [1]. The term “self-sustained” implies a set of chemical reactions capable of harnessing energy from the environment, using it to carry out programmed...
A reliable high-performance liquid chromatographic (HPLC) method which allows the determination in human urine of two important metabolites of N,N-dimethylformamide (DMF), namely N-methylformamide (MMF) and N-methyl-N-(hydroxymethyl)formamide (DMFOH), is reported. A single-step rapid purificatio...
Dimethyl acetylenedicarboxylate (DMAD) is an electron-deficient acetylenic compound having two reactive ester groups. It is a privileged and advantaged molecule, which participates easily and practically in heterocyclization. Due to the presence of two ester electron-withdrawing group, DMAD easi...
The NiII complex of pyrazine-2,5-dicarboxylate is found to be the best catalyst containing a divalent metal center ever discovered for the hydrolysis of bis(p-nitrophenyl) phosphate.
The intramolecular Friedel–Crafts acylation of arenes with Meldrum's acid derivatives catalyzed by Sc(OTf)3 was reported as a mild and general entry into functionalized 1-indanones. Mechanistic investigations were undertaken to determine the rate-determining step in the acylation sequence ...
A total synthesis of sulfobacin A, a von Willebrand factor receptor antagonist, is described. Our synthetic approach relies uniquely on catalytic asymmetric reactions for the creation of the three stereogenic centers without using chiral building blocks. The key steps of this short route to sulf...
Single electron transfer induced elemental steps have been shown to occur during the transformation of iodomalonic esters and related CH-acids to cyclopropane derivatives under solid-liquid phase transfer catalytic conditions. The iodo derivatives are formed from iodine and CH-acids “in situ”,...
5-Oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) is formed from 5S-hydroxy-6,8,11,14-eicosatetraenoic acid (5-HETE) by the 5-lipoxygenase (5-LO) pathway under conditions associated with oxidative stress. 5-Oxo-ETE is an important pro-inflammatory mediator, which stimulates the migration of eosi...
Two de-lignified cellulose of loofah sponge and sawdust were applied in two ways to enhance the lipid production from oleaginous yeast using acetic acid. When 30 g/L of acetic acid was used as a carbon source, direct addition of de-lignified loofah sponge or sawdust increased the extracellular l...
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