BackgroundDextrorphan with long-acting local anesthetic effects did not cause system toxicity as fast as bupivacaine, while catecholamines (i.e., epinephrine) with the vasoconstrictive characteristics enhanced the effects of local anesthetic drugs. The objective of the experiment was to examine ...
The terrestrial snail, Cepaea nemoralis, when placed on a surface heated at 40°C lifts the anterior portion of its foot from the source of heat. This stereotyped response, which suggests aversion, can be inhibited by injections of small doses of morphine and levorphanol, but is not affected by ...
SUMMARYThe effects of a mixture of 1 part levallorphan and 10 parts levorphanol taken by mouth were studied in subjects needing symptomatic control of intractable pain. Response varied according to previous treatment with potent analgesics. The effects were similar to those of the same dose of l...
Alkaloids were separated from urine in 15 min with an Amberlite XAD-2 resin column, and the methanol eluate was chromatographed on 2 thin-layer silica gel glass microfiber sheets to establish a pattern of spots for each narcotic analgesic and its metabolites. Ten milliliters of urine applied to ...
The effects of the stereoisomers dextrorphan and levorphanol on the excitation of spinal neurons by electrophoretically administered excitatory amino acids were studied in pentobarbitone-anaesthetised rats. Both isomers reduced responses to N-methyl-DL-aspartate (NMA), dextrorphan being both mor...
Interactions of (±)-propranolol HCl with various narcotics were determined in albino rats. The 24-h intraperitoneal (i.p.) LD50 of morphine sulfate + saline was 15–16 times greater than for morphine + propranolol in both sexes although morphine was nearly twice as toxic to males as to females....
Intrathecal administration of dextromethorphan and levorphanol and intravenous injection of dextromethorphan were tested on the electrophysiological response of deep multireceptive dorsal horn neurones to peripheral stimuli. Both blockade of C-fibre input to the cells and wind-up, the increase i...
Intraspinal injection of levorphanol (3 μg) at the lumbar area of the leopard frog,Rana pipiens, induced analgesia which was completely blocked by co-injection of naloxone (3 μg), whereas dextrorphan (3 μg) induced analgesia which was unaffected by naloxone. Subcutaneous levorphanol (20 or 80...
1. Dose-response curves were constructed for duration of significant catalepsy in male Sprague-Dawley rats following i.p. administration of four established and two novel narcotic analgesics.2. The relative potency of the six drugs was levorphanol > monacetylmorphine > diacetylmorphine > dibutan...
A new electromyographic (EMG) method described by Bieger et al. (1972) was developed for the quantitative evaluation of narcotic analgesics in rats anesthetized with urethane. d-Amphetamine increased the amplitude and the frequency of myoclonic twitch activities (MTA) of suprahyoideal muscle. Mo...
Clinically, patients often demonstrate incomplete cross-tolerance between opiate analgesics. Although dispositional and pharmacokinetic factors may be a factor, our results suggest that differences in selectivity of various opioids for those opioid receptor subtypes involved in analgesia, mu1, k...
Electronic cigarettes (e-cigarettes) were developed as an alternative method for nicotine delivery and had a significant surge in popularity. E-liquids are formulations used in e-cigarettes, and consist of a ratio of propylene glycol (PG) and vegetable glycerin (VG), a pharmaceutical and/or herb...
The aim of the present study was to determine the involvement of the VTA 5-HT1A receptors in analgesia induced by the co-administration of morphine and dextromethorphan (DM). Male Wistar rats were bilaterally cannulated in the VTA by the stereotaxic instrument. The tail-flick and formalin tests ...
This study investigated the protective effects of dextromethorphan (DXM) on noise-induced hearing loss (NIHL) in rats. This study aimed to improve the auditory threshold and to understand the protective effects of DXM against N-methyl-d-aspartate (NMDA)-induced neurite degeneration of serotonerg...
A variety of nicotinic drug treatments have been found to decrease nicotine self-administration. However, interactions of drugs affecting different nicotinic receptor subtypes have not been much investigated. This study investigated the interactions between dextromethorphan, which blocks nicotin...
Dextromethorphan is the most commonly used over-the-counter anti-tussive and expectorant medicine at therapeutic doses. Due to easy availability, euphoric high and hallucinogenic effects at larger doses, dextromethorphan popularity amongst the drug abusers is growing day by day. It is often mixe...
Dextromethorphan, a wildly used over-the-counter antitussive drug, is reported to have anti-inflammatory effects. Previously, we and others have demonstrated that dextromethorphan at micromolar doses displays potent hepatoprotective effects and enhances mice survival in a sepsis model. Moreover,...
The enantioselectivity of the interaction of dextromethorphan (DM) and levomethorphan (LM) with an immobilized α3β4 subtype of the nicotinic acetylcholine receptor (nAChR) liquid chromatographic stationary phase has been compared to DM- and LM-induced non-competitive blockade of nicotine-stimu...
Europium and praseodymium chiral NMR shift reagents were used to differentiate between dextro- and levomethorphan. The enantiomeric shift differences (ΔΔδ) demonstrated by the singlet associated with the methoxy protons were large enough to identify the levo- and dextro-isomers and to allow f...
A new enantioselective HPLC method was developed for the resolution and determination of the enantiomers of methorphan, dextromethorphan (DXM) and levomethorphan (LVM), on a Chiralcel® OJ column (250 mm × 4.6 mm I.D.). The resolution of DXM and LVM was obtained using a mobile phase consisting o...
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View