Usnic acid, which is the most widespread and well-studied secondary lichen compound, has antibacterial and cytotoxic effects. Usnic acid is present in lichens as the (+)- and (-)-enantiomers, which have different biological activities. We used a DNA-comet assay to determine the genotoxic effect ...
With the myriad of drugs which have been recommended for obstetrical analgesia and amnesia, a certain amount of confusion and indecision has arisen as to the most satisfactory form of medication. As a result of this indecision some obstetricians have finally eliminated any routine form of analge...
An assay for aminophylline-vinbarbital solutions through their silver salts has been developed. This method combines the U. S. P. XIV assay for aminophylline with a modification of the Budde assay for barbiturate. The ability of the Budde assay to eliminate interference by barbiturate decomposit...
□ A sensitive postcolumn ionization high-performance liquid chromatographic (HPLC) method for the quantitative determination of butabarbital sodium in butabarbital sodium elixir is described. The procedure employs a octadecylsilane column chemically bonded to porous silica microparticles. The m...
Primidone is an anticonvulsant drug and is indicated for the treatment of seizures and essential tremor. The proposed anticonvulsant activity of primidone and its active metabolite, phenobarbital, is by enhancing inhibition via the GABAA receptor. The antitremor mechanism of primidone is not kno...
Many antiepileptic drugs (AEDs) produce sexual impairments. Of commonly prescribed AEDs, primidone produces the greatest impairments. Here we examined the effects of primidone on male rat sexual behavior. Sexually-experienced male rats received administration of either vehicle or primidone. Afte...
The present study was to determine the effectiveness of electron beam irradiation for degradation of the antiepileptic drug primidone (PMD) in aqueous solution. The results showed that PMD degradation followed pseudo-first-order kinetics. The dose constant determined in this study ranged from 1....
RésuméLa primidone est un antiépileptique mineur de première génération, très peu prescrit dans cette indication actuellement, mais qui, hors autorisation de mise sur le marché, reste un traitement de première ligne du tremblement essentiel. Bien qu’elle se métabolise en phényl-éthy...
Primidone (125-33-7) is an anticonvulsant used in the treatment of generalized tonic–clonic and partial focal seizures. It is structurally similar to phenobarbital, and its anticonvulsant properties result from its metabolism to phenobarbital and phenylethylmalonamide. Toxic effects typically i...
Primidone with its two active metabolites, phenobarbital and phenylethylmalonic acid (PEMA), is an anticonvulsant drug that is indicated for the treatment of partial epilepsy. In addition to treatment of seizures, it is also indicated as the first line therapy for the management of essential tre...
Pharmaceutical and personal care products (PPCPs) are a group of emerging contaminants that have frequently been detected in aqueous environments. Phototransformation driven by solar irradiation is one of the most important natural processes for the elimination of PPCPs. In this study, primidone...
A graphene oxide-titania (GO/TiO2) composite was synthesized via sol-gel method, and studied in aqueous Primidone mineralization with ozone and LED visible light. The photocatalyst was characterized by different techniques (XRD, TEM, SBET, TGA, UV–vis diffuse reflectance spectroscopy). The band...
A case of acute opiate intoxication due to Dipipanone is reported, with successful use of N-allylnormorphine in treatment. The value of Straub (mouse-tail) test is emphasised as are its limitations.
A reversed-phase high-performance liquid chromatography method is described which is capable of determining the drug dipipanone in urine and plasma at concentrations down to 20 ng/ml.
BackgroundThe Drug Enforcement Administration (DEA) changed hydrocodone-containing products (HCPs) from Schedule III to II status on October 6, 2014, making codeine-containing products (CCPs) the only non–Schedule II oral opioid agents.
BackgroundUrine drug monitoring is used by physicians treating chronic pain patients with opioid therapy. Patients are tested in part to insure that they are not taking other drugs. Therefore, the finding of hydrocodone in a patient who is only prescribed oxycodone has clinical implications. Oxy...
Abuse of prescription opioid analgesics in non-medical context has been on the rise over the past decade. The most commonly abused analgesic in this drug class consists of a combined formulation of hydrocodone and acetaminophen. The present study was aimed to determine the rewarding effects of h...
BackgroundGenetic variations in enzymes that produce active metabolites from pro-drugs are well known. Such variability could account for some of the clinically observed differences in analgesia and side effects seen in postoperative patients. Using genotyping and quantitation of serum concentra...
PurposeA single-entity, once-daily, extended-release formulation of hydrocodone bitartrate (HYD) has been developed for the management of moderate to severe chronic pain. Hydrocodone undergoes cytochrome P-450 (CYP)-mediated metabolism involving the CYP3A4 and CYP2D6 isozymes. CYP3A4 yields norh...
Hydrocodone (HYD) is one of the most widely prescribed opioid analgesic drugs. Several neurotransmitters are involved in opioids relapse. Among these neurotransmitters, glutamate is suggested to be involved in opioid dependence and relapse. Glutamate is regulated by several glutamate transporter...
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