This study aimed to assess the effect of a single IM injection of hydrocortisone succinate in relieving the immediate post-varicocelectomy scrotal edema. In all, 117 patients with grades II and III varicocele who developed post-varicocelectomy scrotal edema were randomly classified into group A ...
Background: Bronchospasm after intravenous hydrocortisone treatment has been reported in some patients with aspirin-sensitive respiratory disease. Objective: This study was designed to determine the prevalence of sensitivity to hydrocortisone among patients with aspirin-sensitive respiratory dis...
Controlled release of hydrocortisone sodium succinate from a device consisting of a drug containing a core of polymethyl methacrylate was achieved by the use of a design incorporating impermeable barriers to drug diffusion and the use of a semipermeable membrane. Initial in vivo study showed sus...
Parenteral aseptic preparations of hydrocortisone sodium succinate (HSS) are used frequently in hospitals, but little definitive stability information is available. The purpose of this study was to obtain ultimate shelf lives for typical formulations so that they may be prepared in bulk in appro...
The alkaloid cevine has been shown to have configuration II. The configurations of nine (C3, C4, C5, C9, C10, C12, C14, C17, C25) of the fourteen asymmetric centers were established by earlier work. Hydrogenation of 16-dehydrocevine 3,4-diacetate (XIII) over platinum proceedeb stereoselectively ...
The purpose of this report is to present out experience with the use of protoveratrine in one hundred patients with hypertensive vascular disease. It is not possible to give a final answer as to the effect of this drug as a treatment of patients with hypertension. We cannot do this because the e...
Several known antiemetics and other compounds were evaluated for their ability to prevent protoveratrine induced emesis in dogs and found to be ineffective.
Protoveratrine was administered orally in 30 hyptertensive patients. These patients were unselected in so far as their age and the probable cause of the hyptertension was concerned. Twenty-five were considered as having essential hypertension, four, chronic glomerulonephritis and one, pheochromo...
1.1. Six hypertensive patients receiving protoveratrine developed various forms of cardiac arrhythmias on nine occasions. These arrhythmias consisted of sinus bradycardia, sinus arrest, wandering pacemaker, first-degree atrioventricular block, and partial and complete atrioventricular dissociati...
In view of the significant pharmacological differences between protoveratrine A and protoveratrine B when the substances are administered orally, and of our recent revelation that the structures of the two compounds differ only in the nature of the acid moiety of the ester at C3, a series of ana...
1.1. A brief history of the use of Veratrum preparations in the treatment of toxemia of pregnancy is given.2.2. A brief description of the source, pharmacologic and clinical effects of Veratrum preparations and protoveratrine is presented.3.3. An outline of a safe and effective method of dosage ...
Commercial preparations of protoveratrines A and B were found to contain several associated veratrum alkaloids. The individual alkaloids may be separated by partition chromatography, using pH 3.0 buffer adsorbed on Celite® as stationary phase.
Infrared and titrimetric procedures for the evaluation of protoveratrine mixtures are reported which are not specific for either protoveratrine A or protoveratrine B. A method for the quantitative estimation of protoveratrine A and protoveratrine B is described in which the alkaloids are separat...
The protoveratrine A and B complex can be quantitatively separated into its component alkaloids by partition chromatography over Celite® in which a mixture of pH 3.5 buffer and ethylene glycol is incorporated as immobile phase. Benzene elutes the protoveratrine A, while ethylene chloride elutes ...
The effect of protoveratrines A and B (PA and PB) on the uptake of a model amine, levo-metaraminol (1-MA) by rabbit heart in vitro was investigated.PA is a good inhibitor of 1-MA uptake acting by an uncompetitive mechanism. PB has no detectable effect of the uptake in ordinary conditions, but be...
An ultra-high pressure liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) method was successfully developed and qualified for the simultaneous determination of triamcinolone hexacetonide (TAH) and triamcinolone acetonide (TAA, the active metabolite of TAH) in rabbit plasma. To prevent...
BackgroundThe pathogenesis of bladder pain syndrome (BPS) remains incompletely defined, and there is no standard treatment for BPS as yet.
After application to the skin surface, a topical formulation is submitted to changes in composition produced by evaporation of volatile components, penetration of components into the skin and extraction of skin components (“vehicle metamorphosis”). The aim of this work was to study the effect ...
PurposeTo report a case of triamcinolone crystals associated miliary microemboli of the retinal arterioles and choriocapillaris.
With the emergence of propranolol as the first choice of treatment for problematic infantile haemangioma at many centres, the number of patients with a partial or non-response to propranolol has also been growing. This study investigated the role of intralesional bleomycin and triamcinolone in p...
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