Two novel spectrophotometric methods were presented in this work using ethanol as a solvent. The first method was the ratio difference spectrophotometric method [RDSM], in which the amplitude difference between two selected wavelengths on the ratio spectra were recorded and used for estimation o...
A simple, rapid and fully-validated liquid chromatographic method (RP - HPLC) with fluorescence detection was developed for the analysis of rhein (as the main metabolite of diacerein) in human plasma. The separation was performed using an ODS C18 column with a mobile phase consisted of acetonitr...
The ligand-free Pd-mediated reaction between styrene and a 6-bromo-2,2-diaryl-2H-[1]benzopyran proceeded anomalously to give a 2-(diarylmethyl)-5-styrylbenzofuran via a tandem Heck coupling – ring-contraction process; none of the styryl substituted 2,2-diaryl-2H-[1]benzopyran was observed. A 2,...
Ten coumarin derivatives containing (E)-methyl 2-(methoxyimino)-2-phenylacetate were synthesized and bioassayed. The compounds were identified by IR, 1H NMR and elemental analyses. The test results indicated that compound 5j (R1 is methyl and R2 is n-C6H13) was the optimal structure in this pape...
The replacement of dimethylacetamide with arylacetic acid esters and acetamides at the imidazo[4,5-c]pyridine 5-position of EMD 66684 2 imparts affinity for the AT2 receptor. The highest affinity was found with the phenylacetic acid isopropylester moiety, which led to compound 7c with an IC50 va...
Solvent effects on the absorption and emission spectra of organic compounds have been widely observed. It is usually found that the positions, intensities and shapes of its bands are usually modified by these solvents. The solvent effects on intramolecular charge transfer (ICT) process have been...
Analogues of the hexapeptide angiotensin IV (Ang IV, Val1-Tyr2-Ile3-His4-Pro5-Phe6) encompassing a 4-hydroxydiphenylmethane scaffold replacing Tyr2 and a phenylacetic or benzoic acid moiety replacing His4-Pro5-Phe6 have been synthesized and evaluated in biological assays. The analogues inhibited...
Organopalladium complexes derived from 2-(bromomethyl)benzenemethanol, 2- bromo- and iodobenzenemethanols and 2-iodobenzeneethanol are efficient catalysts for the reaction of carbon monoxide and arylmethyl halides leading to arylacetic acids and esters.
A highly sensitive and rapid liquid chromatographic method for the determination of free and total phenylacetic and p- and m-hydroxyphenylacetic acids in human urine is described. After extraction of urine with diethyl ether, these acids and phenylpropionic acid (internal standard) are converted...
A major part of modern analytical problem solving deals with the trace level determination of organic compounds and contaminants in biomedical, food and environmental samples. In the analysis of these samples chromatographic techniques play a predominant role. Unfortunately, however, even the co...
Benzyl halides are efficiently carbonylated to phenylacetic acids in the presence of a catalytic amount of the dimer of chloro(1,5-cyclooctadiene)rhodium(I) in formic acid. Under these reaction conditions, sensitive functionalities such as esters and nitriles are tolerated and the phenylacetic a...
A new preparation of 4-(BOC-aminoacyloxymethyl)phenylacetic acids 1, consisting of an esterification of the corresponding BOC-amino acids 2 with 4-(bromomethyl)phenethyl alcohol 3, followed by a Collins oxidation and an oxidation with sodium chlorite is described. The overall yields range from 5...
Lithiation of 6-methyl-2-(trimethylsilylamino)pyridine (APyTMSH) occurs smoothly in tetrahydrofuran (thf) affording [Li(APyTMS)(thf)]2 (1). Treatment of anhydrous lanthanoid chlorides (LnCl3, Ln=Gd, Er) with 1.5 equivalents of (1) yields the solvent-free homoleptic tris–amido complexes [Ln(APyT...
Treatment of 2-picoline with BunLi in THF affords its corresponding 2-picolyl lithium salt in a high yield. The insertion of benzonitrile into the LiC bond of 2-picolyl lithium followed by acidic hydrolysis yields the corresponding β-pyridyl ketone (1), and diketone compounds (2) is obtained fr...
Hexamethyldisilazane and 1,1,1-trimethyl-N,N-bis(trimethylsilyl) stannaneamine aminate pentafluoropyridine, octafluorotoluene, pentafluorobenzonitrile, pentafluoronitrobenzene and pentafluorobenzene sulphonyl fluoride in the presence of caesium fluoride with formation of the corresponding perflu...
Publisher Summary2-(Thienyl)silane, 5-methyl- and 5-chloro-2-thienylsilane are prepared in 77–87% yield from the corresponding thienyltrichlorosilyl compounds and lithium aluminium hydride in diethyl ether. Phenylvinyl-(2-thienyl)silane is prepared by reduction of phenyl vinyl(2-thienyl)chloros...
This study demonstrates that tin porphyrin (SnP) loading on a silica substrate (SnP/silica) markedly accelerates the degradation of Microcystins (MCs) under visible light irradiation, despite a reduction of photosensitized singlet oxygen (1O2) production. A comparative study using Rose Bengal, S...
This chapter discusses organotin compounds, and their extensive use in organic synthesis is briefly outlined. After an account of spectroscopic methods and the reactions by which the tin-carbon bond can be formed, the different types of organotin compounds, and their various derivatives are disc...
Developments in the Main Group 1, 2, 13–15 and Groups 11 and 12 alkyl metal or metalloid chemistry of CH(SiMe3)(2-pyridyl) (= r) and C(SiMe3)2(2-pyridyl) (= R) is reviewed along with observations on the closely related ligands, CH(SiMe3)(6-methyl-2-pyridyl) (= rMe) and C(SiMe3)2(6-methyl-2-pyri...
Starting from a 1,2-O-isopropylidene-α-d-xylofuranose derivative, a non-toxic free-radical approach for the synthesis of (+)-muscarine is reported. To this end, a stereoselective allylation reaction at the anomeric position of a respective xylofuranose derivative was employed as a new synthetic...
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