The measurement of the fluorescence emitted by flavones and flavonols in situ on thin-layer chromatography plates can be improved by dipping the developed plates in appropriate solutions. The effect of different substances on the intensity and stability of the fluorescence of 14 flavone and 26 f...

Two new tetracopper(II) complexes bridged by N-benzoate-N′-[3-(diethylamino)propyl]oxamide (H3bdpox), and ended with 4,4′-dimethyl-2,2′-bipyridine (Me2bpy) or 2,2′-bipyridine (bpy), namely [Cu4(bdpox)2(Me2bpy)2](pic)2 (1) and [Cu4(bdpox)2(bpy)2](pic)2·2H2O (2) (where pic denotes the picrate...

The effect of cyclodextrin (CD) complexation on the fluorescence properties of ethyl-4′-dimethylaminobenzoate (EDMAB) was studied. The complex exhibited dual fluorescence whereas no TICT fluorescence was observed in aqueous solution without α-CD. At lower concentrations of α-CD, the TICT emis...

Antibiotic resistance among clinically significant bacterial pathogens is becoming a prevalent threat to public health, and new antibacterial agents with novel mechanisms of action hence are in an urgent need. Utilizing computational docking method and structure-based optimization strategy, we r...

A simple and efficient Rh(III)-catalyzed C-H activation and tandem intramolecular cyclization for the synthesis of isocoumarins has been developed. The protocol uses easily available primary benzamides and cyclic 2-diazo-1,3-diketones as starting materials. This reaction proceeds via C-C and C-O...

The UV photolysis of 2′-chloro-4-R-benzanilides in acetonitrile solution under nitrogen atmosphere leads to the formation of intramolecular photocyclization products (9-R-phenanthridin-6(5)-one, 20–30%), along with the minor photoreduction, photo-Fries, and intramolecular photosubstitution pro...

N1-Phenyl-3,5-dinitro-N4,N4-di-n-propylsulfanilamide (1) and N1-phenyl-3,5-dinitro-N4,N4-di-n-butylsulfanilamide (2) show potent in vitro antimitotic activity against kinetoplastid parasites but display poor in vivo activity. Seventeen new dinitroaniline sulfonamide and eleven new benzamide anal...

A new series of N-(2-hydroxy-4(or 5)-nitro/aminophenyl)benzamide and phenylacetamide derivatives (1a–1n, 2a–2n) were synthesized and evaluated for antibacterial and antifungal activities against Staphylococcus aureus, Bacillus subtilis, Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichi...

2-(Cyclohexylamino)-2-oxo-1-(pyridin-2-yl)ethyl benzoate has been synthesized and characterized by elemental analysis, FT-IR, 1H NMR and 13C NMR. Geometrical structures, vibrational frequencies, 1H and 13C chemical shift values, molecular electrostatic potential maps and several thermodynamic pa...

Herein we present the development of a powerful CE–UV method able to detect and quantify an important number of phenolic acids in 13 varieties of avocado fruits at 2 ripening stages. All the variables involved in CE separation were exhaustively optimized and the best results were obtained with ...

Isocyanide-based MCRs (IMCRs) involving for the first time the biological and pharmaceutical active indoleacetic acids are studied. In particular, the catalytic behavior of 2-acetyl-indoleacetic acid in the Ugi three-component reaction with TosMIC is emphasized. The reaction was optimized, revea...

An increased number of sulfate-reducing bacteria is often isolated from faeces of patients with gastrointestinal diseases, which can be the cause of the development of bowel inflammation. Frequent use of antibiotics causes the resistance of intestinal microorganisms and ineffective treatment of ...

A series of 20 novel 1-(4-sulfamylphenyl)-3-trifluoromethyl-5-indolyl pyrazolines were designed, synthesized, and screened in vitro for anti-inflammatory activity. These compounds were designed for evaluation as dual inhibitors of cyclooxygenases (COX-1 and COX-2) and lipoxygenases (LOX-5, LOX-1...

A series of novel 4-thiazolidinone and indolin-2-one hybrid derivatives 5a–5s and 10a–10s have been designed and synthesized and their cytotoxic activities were evaluated in vitro against three human cancer cell lines including HT-29 (human colon cancer), H460 (human lung cancer), MDA-MB-231 (...

Intermedine and lycopsamine are diastereoisomers containing vicinal glycol groups of different configuration. The difference in the degree to which they complex with borate is the basis of two procedures for their separation from mixtures on a preparative scale. In the first, the mixture dissolv...

The total syntheses of (−)-indicine N-oxide, the enantiomer of natural indicine N-oxide and intermedine N-oxide have been achieved.

The corrosion behavior of ISO AlMg2 (AA5052) was studied at the microscale using the Electrochemical Microcell Technique. The influence of plastic deformation on the corrosion resistance of this alloy was also examined. After polishing, pitting at small copper-enriched precipitates and structura...

NaYF4:Er/Yb/Gd upconversion nanoparticles (UCNP) capped with amino groups were covalently attached to chloro aluminium tetrasulphonated phthalocyanine (ClAlTSPc) and chloro aluminium tetracarboxy phthalocyanine (ClAlTCPc). The conjugates were characterized using different techniques such as infr...

D-pinitol (3-O-methyl-D-chiro-inositol) is a well-known bioactive compound with anti-diabetic and anti-oxidant biological functions. A gas chromatography–mass spectrometry (GC–MS) method was developed for its quantitation in carob syrup, flesh and seed samples originated from Cyprus. The analy...

Alkylmercuric benzoate and chloride formed in the benzoyl peroxide-initiated reaction of dialkylmercury in carbon tetrachloride solutions arise by homolytic displacements. Kinetic isotope effects demonstrate that any alkylmercuri radicals formed in the concurrent reductive elimination to metalli...