In this work, benzyl butyrate was synthesized for the first time via biotechnological esterification of benzyl alcohol and butyric acid in a solvent-free system (SFS). The synthesis was maximized in batch reactors, considering a low substrates molar ratio of 1:1. Novozym 435, a well-known commer...

The reaction of perfluoroketene dithioacetal with lithium dienediolates of carboxylic acids proceeds at the ω position probably through an addition to the π system followed by elimination of the vinylic fluoride. The preparative value of this reaction depends strongly on the reaction and work-...

tert-Butylation of naphthalene is a potential technology to produce 2,6-di-tert-butylnaphthalene (2,6-DTBN), which is a valuable raw material for the synthesis of polyethylene naphthalate (PEN). Alkaline, acid and combined alkaline-acid treatments were adopted to regulate the porosity and acidit...

The finding in a previous study from this laboratory that homogentisic acid inhibits protein synthesis in microsomal systems from mammalian tissues led to the present investigation on the possible mechanism of this inhibition. It was determined that homogentisic acid inhibits the transfer of ami...

A large fraction of the known human metabolome belong to organic acids. However, comprehensive profiling of the organic acid sub-metabolome is a major analytical challenge. In this work, we report an improved method for detecting organic acid metabolites. This method is based on the use of liqui...

Horse-radish peroxidase catalyzes the oxidation of homogentisic acid in the presence of sulfhydryl compounds to form products similar to those obtained by the spontaneous reaction of benzoquinoneacetic acid with sulfhydryl agents. Other heme proteins, such as catalase, cytochrome c, hemoglobin a...

The metabolic disorder, alkaptonuria, is distinguished by elevated serum levels of 2,5-dihydroxyphenylacetic acid (homogentisic acid), pigmentation of cartilage and connective tissue and, ultimately, the development of inflammatory arthritis. Oxygen radical generation during homogentisic acid au...

Ochronotic pigmentation of connective tissues occurs in individuals with alcaptonuria. An enzyme system, termed homogentisic acid polyphenol oxidase, has been identified in mammalian skin and cartilage which catalyzes the oxidation of homogentisic acid to an “ochronotic-like” pigment. Benzoqui...

The chloro and bromo compounds of cobalt, copper and zinc with 3-methyl-3-phenyl-pyndine were prepared in ethanolic solution from which solid compounds were isolated. The suggested structure for the cobalt and zinc compounds is tetrahedral, while for the copper compounds it is tetragonal. The te...

We report the application of four novel tetraphenyl silicon derivatives as host materials in phosphorescent organic light-emitting diodes (PHOLEDs). The novel derivatives are; 3-(4-((4-(dibenzo[b,d]thiophen-4-yl)phenyl)diphenylsilyl)- phenyl)pyridine (DBTSiPy3), 4-(4- ((4-(dibenzo[b,d]thiophen-4...

New pyrazoles and pyrazolo[3,4-b] pyridines were synthesized and their structure was confirmed by elemental analyses as well as IR, 1H NMR, 13C NMR, and mass spectral data. All the newly synthesized derivatives were evaluated in vitro for inhibitory activity against COX-1 and COX-2 enzymes and t...

The oxidation of the tri(o-tolyl)phospine complex of the doubly cyloplatinated 2,6-di(4-fluorophenyl)pyridine ligand with the electrophilic oxidant iodobenzenedichloride was studied. Three products were formed in the ratio 15:15:70, and all were identified. The simple cis-dichloro platinum(IV) c...

The aim of this work is the electrochemical synthesis of a new type of material possessing the properties of organic conductive polymers along with those of organometallic complexes, for their use in asymmetric heterogeneous catalysis. The synthesis of (S,S)-5,5′-bis-[3-(3-methyl-pentyl)-thioph...

A series of C2-symmetrical bis[(E)-2-(4-pyridyl)ethenyl]arenes has been synthesised via two-fold PO-activated olefinations. 1,4-Benzene, 1,4-naphthalene, 9,10-anthracene and 2,2′-diphenyl were used as central units. These fluorescent compounds were freely soluble in common solvents. The absorpt...

[1,2,3]Triazolo[4,5-h][1,6]naphthyridines and [1,3]oxazolo[5,4-h][1,6]naphthyridines were synthesized with the aim to investigate their photocytotoxic activity. Upon irradiation, oxazolo-naphtapyridines induced light-dependent cell death at nanomolar/low micromolar concentrations (EC50 0.01–6.5...

1-(Dimethylamino)-1-phenyl-1-silacyclohexane 1, was synthesized, and its molecular structure and conformational properties studied by gas-phase electron diffraction (GED), low temperature 13C NMR spectroscopy and quantum-chemical calculations. The predominance of the 1-Phax conformer (1-Pheq:1-P...

A catalytic photometric method was developed for the determination of sub-nanogram levels of cobalt. The method is based on the catalytic effect of cobalt(II) on the oxidative coupling of 3-methyl-2-benzothiazolinone hydrazone with N-ethyl-N-(2-hydroxy-3-sulfopropyl)-3,5-dimethoxyaniline (DAOS) ...

Several new copper(II) complexes (4–6) with N-dimethoxyphenyl-3,5-tBu2-salicylaldimine ligands abbreviated as N-R-3,5-DTBS, where R = 2,4-dimethoxyphenyl (1), 2,5-dimethoxyphenyl (2) and 3,5-dimethoxyphenyl (3) have been prepared and their spectroscopic (IR, 1H NMR, UV/Vis, ESR), magnetic and r...

1,2-Indanediones are a new class of fluorogenic reagents for amino acid visualization. In order to better understand the mechanism of formation of the resulting fluorescent products, we have examined the reactions of 1,2-indanediones with amino compounds. Treatment of 1,2-indanedione with 3,5-di...

Solid-state high-power heat output at a relatively low temperature is a core problem for photo thermal batteries (PTB) films because of the fundamental contradiction between fast heat release and low-rate isomerization. To overcome this problem, imidazole-containing azoheteroarene (i-Azo-h) is i...