By using cyclic voltammetry (CV), sunset yellow film was electrodeposited on the surface of carbon paste electrode by electropolymerization technique to obtain the poly (Sunset yellow) modified carbon paste electrode (CPE). The fabricated poly (Sunset yellow) modified CPE showed excellent electr...

PFAAs have emerged as persistent organic pollutants (POPs) in a variety of environmental matrixes and biota, posing potential hazards for wildlife and humans. Diet has been considered as an important source for human exposure to PFAAs and seafood accounts for a relatively large proportion in hum...

Reconstructing the Plio-Pleistocene sedimentary history of the Yellow Sea, is important for understanding the long-term influence of the Yellow River (Huanghe) and/or Yangtze River (Changjiang) on the Asian marginal seas and to further constrain any links between river development, regional pale...

A copper(I)-NHC-catalyzed annulation of 5-membered cyclic enols of furan, thiophene and indene family with 3-aryl-2H-azirines has been developed to provide a rapid access to furo[3,4-b]pyrrole, thieno[3,4-b]pyrrole, indeno[1,2-b]pyrrole derivatives. The reaction proceeds via a copper-initiated N...

Class I phosphoinositide 3-kinases (PI3Ks), particularly PI3Kγ, have become attractive drug targets for inflammatory and autoimmune disorders such as rheumatoid arthritis. Herein, we describe the synthesis and the structure–activity relationships (SAR) of a series of 2-amino-5-oxadiazolyl thia...

The effect of water properties on solid acid catalysis using TiO2 as the catalyst in sub- and supercritical water was elucidated using the reactions of 1-octene and 2-octanol as models. Kinetic data for these reactions at 290–410 °C and 25 MPa were analyzed, and relationships between reaction ...

Functionalization of the catalytic loop of 10–23 DNAzyme with an amino group was performed by incorporation of 7-(3-aminopropyl)-8-aza-7-deaza-2′-deoxyadenosine in different single positions. Among the nine modified positions in the catalytic loop, A9 is the unique position with positive contr...

A novel reversed Hoogsteen mode is observed for the base-pairing of 8-amino-2′-deoxyadenosine with 2′-deoxythymidine in low dielectric solvent. The results may have important significance for designing novel DNA duplexes and triplexes incorporating 8-amino-dA.

Solid phase synthesis of modified oligonucleotide 5 containing 8-amino(2-aminoethyl)-2′-deoxyadenosine unit is reported using trifluoroacetyl as a C8-side chain amino protector.

At the sites of inflammation, hypohalous acids, such as hypochlorous acid and hypobromous acid (HOBr), are produced by myeloperoxidase. These hypohalous acids rapidly react with the primary amino groups to produce haloamines, which are relatively stable and can diffuse long distances and cross t...

Debromination of 8-bromo-2′-deoxyguanosine was accomplished in high yield under neutral conditions in aqueous methanol by irradiating with visible light in the presence of methylene blue as a sensitizer and triethylamine as an electron donor. The method can be extended for the debromination of ...

The synthesis of 6-benzyloxycarbonyl-1-oxa-6-azaspiro[4.5]decan-2-one (17) and 6-benzyloxycarbonyl-1,6-diazaspiro[4.5]decan-2-one (18) from the D,L-pipecolic acid derivative 10, is described. The synthesis of (±)-6-benzyl-3-methyl-1,6-diazaspiro[4.5]dec-3-ene-2,7-dione (29), the spiro structura...

Various novel 5-(monosubstituted amino)-2-deoxo-2-phenyl-5-deazaflavins derivatives have been synthesized by direct coupling of 5-deazaflavins and N-alkyl or aryl amines. The antitumor activities against human tumor cell lines CCRF-HSB-2 and KB cells have been investigated in vitro and many comp...

2-Aryl-3-arylamino-4,4,4-trifluoro-2-butenenitriles were obtained as hydrates from 3-oxo-2-aryl-4,4,4-trifluorobutyronitriles and anilines and their structure and heterocyclizations studied. Cyclization with polyphosphoric acid gave poor yields of 3-aryl-2-trifluoromethyl-4-quinolones, but they ...

AimNovel heterocycle 3-cyano 6,9-dimethyl 4-imino 2-methylthio 4H pyrimido [2,1-b] [1,3] benzothiazole 3 has been prepared by using 2-amino 4,7-dimethtyl benzothiazole 1 and bis-methylthio methylene malononitrile 2.

A series of oxazolo[4,5-g]quinazolin-2(1H)-one derivatives employing Erlotinib as lead compound were synthesized and evaluated for their EGFR inhibition activity. These compounds having variation at the 1 and 8-position, included ether and esters hydrophilic side-chain and aromatic head fragment...

In this article, the scintillation properties of 3-(p-toluidino)-5-phenyl-1-p-tolyl-1H-pyrrol-2(5H)-one as a Lactam is studied. m-xylene, cyclohexan, and ethanol are used as solutions, whilst, Anteracene and Naphthalene are used as secondary solvents. The influence of solvent on the scintillatio...

A peptide-like self-immolative molecular clip is required for release of active drugs from prodrugs by endopeptidases. Upon cleavage from the carrier, this clip must collapse and release the drug rapidly. A series of aminoacyl-5,5-dimethylthiaproline (Aaa-Dmt) N-(2-(4-nitrophenyl)ethyl)amides we...

The difficulty of obtaining the sulfoxides of the numerous phenothiazine derivatives now in use in medicine has limited their value in forensic chemistry as a satisfactory means of identifying these important drugs. In this paper is described a relatively simple and efficient method for oxidizin...

In a search of new efficient herbicides of natural origin, four derivatives were prepared from labdane-8α,15-diol (1) and 15-O-acetyl-8α-hydroxy labdane (2) isolated from Croton ciliatoglanduliferus. Their inhibitory activity on photosynthetic electron transport on fresh, broken spinach chloro...