First nucleoside aminooxy acids were synthesized from furanoid sugar phthalimidooxy acids by N-glycosylation with uracil, thymine, N-benzoylcytosine, 6-N-benzoyladenine and 2-N-acetyl-6-O-diphenylcarbamoylguanine. Boc or Fmoc protected uridine aminooxy acid derivatives have also been prepared. A...

The objective of this study was to develop a novel kind of hyaluronic acid-based biomaterials which had the great potentials to be used as dermal fillers or applied in tissue augmentation or filling. A series of sponge-like composites were prepared by cross-linking different amounts of hyaluroni...

Correlation of the efficiency of some dihydrazide derivatives, namely malonic acid (MAD), succinic acid (SAD) and adipic acid (AAD) dihydrazide, against the corrosion of nickel in 1 M sulfuric acid solution is discussed using electrochemical polarization method and quantum chemical calculations ...

Injectable hydrogel allows irregular surgical defects to be completely filled, lessens the risk of implant migration, and minimizes surgical defects due to the solution–gel state transformation. Here, we first propose a method for preparing oxidized hyaluronic acid/adipic acid dihydrazide (oxi-...

The purpose of this investigation was to determine the mechanical properties of films of latexes based on the copolymers butyl acrylate (BA)/methyl methacrylate (MMA)/diacetone acrylamide (DAAM) and BA/MMA/vinyl neo-decanoate (VEOVA-10)/DAAM and the corresponding self-crosslinked copolymers usin...

Promising treatment approaches in repairing tissue defects include implementation of regenerative medicine strategies, particularly delivery of preadipocytes to sites where adipose tissue damage needs to be repaired or where fat needs to be generated. In this study, we suggest that the injectabl...

Adipic acid dihydrazide (ADH) as one of the most widely used homobifunctional linkers in bioconjugate chemistry was used to prepare active forms of originally neutral mannans from the three pathogenic yeasts (Candida albicans, Candida tropicalis, Candida glabrata). A combination of the simple an...

Herein, we describe the successful construction of novel electrospun fibermats from the cross-linkable copolymer poly (acrylamide)-co-poly (diacetone acrylamide) (PAM-co-PDAAM) with the molar ratio of acrylamide and diacetone acrylamide units 8:2 (PAM-co-PDAAM(8:2)) by in situ cross-linking duri...

Adipic acid dihydrazide (ADH) was used to cross-link carboxymethyl chitosan (CMCS) microspheres for Cu2+ removal from aqueous solution. SEM, FTIR, XPS and BET techniques were performed to characterize the ADH cross-linked CMCS (ADH-CMCS) microspheres. The effects on adsorption capacities of pH v...

Two ladder-chain zinc coordination polymers were synthesized in aqueous or N,N-dimethylformamide (DMF) solution by use of adipic acid dihydrazide (adih) precursor: {[Zn2(H2aph)(pim)2]·4H2O}n (pim = pimelate, H2aph = adipic bis(2-picolinylidene)hydrazide) and {[Zn2(adih)3][NO3]4·2DMF}n. X-ray c...

A single crystal of adipic acid dihydrazide, ADH, has been analyzed. Its reaction with Co2+, Ni2+, Cu2+, Zn2+, Cd2+, Hg2+, Ag+, Pd2+ and/or Pt2+ gave homometallic and heterometallic complexes which are characterized by partial elemental analysis, spectra (MS, ESR, 1H NMR, electronic; IR), therma...

Glyphosate, the most commonly used herbicide in the world, can be degraded into more toxic and persistent products such as aminomethylphosphonic acid (AMPA) or non-toxic products such as sarcosine and glycine. In this study, we used liquid chromatography mass spectrometer (LC-MS) to identify gly...

Though applications of TiO2 thin films in environmental pollution remediation are promising, up to date, photocatalytic efficiency is still a challenge. Herein, we report enhanced photocatalytic activity of mesoporous TiO2 thin films towards degradation of organic pollutants in water due to thei...

Two series of complexes with general formula M(n-butoxide)4−x(maltolate)x, where M = Ti or Zr and x = 0–4, were studied as catalyst for transesterification and esterification, in order to obtain methyl esters. The compounds containing different ratios of maltolate and n-butoxide ligands were sy...

The present study indicates EXAFS direct structural data obtained for zirconium ethoxide, iso- and n-propoxide are alike those for zirconium n-butoxide complexes. This is evident for agreement of structural units of abovementioned alkoxides complexes. Our group developed structural model of n-bu...

tert-Butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate ((3R,5S)-CDHH) is a key chiral intermediate for the side chain synthesis of rosuvastatin. In this study, random mutagenesis, site-saturation mutagenesis and combinatorial mutagenesis methods were applied to improve the activity of a synthesized ...

Lodderomyces elongisporus LH703 isolated from soil samples contained three novel aldo–keto reductases (AKRs) (LEAKR 48, LEAKR 49, and LEAKR 50). The three enzymes were cloned, expressed, and purified to homogeneity for characterization. These three AKRs shared

Alcohol dehydrogenases can catalyze the inter-conversion of aldehydes and alcohols. The t-butyl 6-chloro-(3R,5S)-dihydroxyhexanoate is a key chiral intermediate in the synthesis of statin-type drugs such as Crestor (rosuvastatin calcium) and Lipitor (atorvastatin). Herein, a novel alcohol dehydr...

tert-Butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate ((3R,5S)-CDHH) is the key intermediate for synthesis of atorvastatin and rosuvastatin. Carbonyl reductase exhibits excellent activity toward tert-butyl (S)-6-chloro-5-hydroxy-3-oxohexanoate ((S)-CHOH) to synthesize (3R,5S)-CDHH. In this study, a...

While searching for new HIV integrase inhibitors we discovered that some ethyl malonate amides (EMA) are active against this enzyme. Surprisingly, the main function can only very rarely be found among the reported drug candidates. We synthesised a series of compounds in order to establish and an...