The equilibrium vapor pressures, pe, of the ionic liquid tetraoctylphosphonium bis(2-ethylhexyl)phosphate ([P8888][DEHP]) over the temperature range 409–495 K were determined for the first time using mass loss Knudsen effusion. The pe versus temperature relationship compares well to 1-methyl-3-...

In this study, the possibility of tri-n-decylamine (TDA) was investigated as the extractant in extractive lactic acid fermentation with a recombinant yeast being used. Extractive fermentation with TDA did not provide high l-lactic acid production relative to fermentation without extraction. Thro...

Preincubation of human neutrophils with 1-oleoyl-2-acetylglycerol (OAG) enhances subsequent f-Met-Leu-Phe (fMLP)-stimulated arachidonate mobilization. We have recently demonstrated that preincubation of neutrophils with OAG also reverses inhibition of A23187 stimulated [3H]arachidonate mobilizat...

In order to elucidate the possible role in glomerulosa cells of diacylglycerol released by angiotensin II we have studied the action of a synthetic diacylglycerol, sn-1,2-dioctanoyl-glycerol (DiC8), on aldosterone production and potassium permeability in bovine adrenal cells. DiC8 elicited an in...

In the present study, we investigated the effects of different diacylglycerols in comparison with phorbol 12-myristate 13-acetate (PMA) on eicosanoid-independent phospholipase A2 (PLA2) activation in human platelets and neutrophils. Eicosanoid-independent PLA2 activation was measured under condi...

The reaction products of triethylaluminium with water at a molar ratio of 21 were studied. By means of gel permeation chromatography it was found that raw tetraethyldialuminoxane consists of etnyloligoaluminoxanes, a tetraethyldialuminoxane trimer and triethylaluminium. The isolated pure tetraet...

The binary phase behavior of pure 1,3-dimyristoyl-2-stearoyl-sn-glycerol (MSM) and 1,2-dimyristoyl-3-stearoyl-sn-glycerol (MMS) was investigated in terms of polymorphism, melting and crystallization behavior, SFC, hardness and microstructure. Samples were crystallized at cooling rates of 3.0 and...

New gold(I) complexes containing two 1-[2-(diethylamino)ethyl]imidazolydene ligands have been synthesized and characterized. The X-ray structures of two key compounds are presented. All complexes have been tested for their antiproliferative activities in prostate cancer cell line PC-3. Lipophili...

Publisher SummaryThis chapter presents the nomenclature, physical properties, synthesis, and methods of analysis of sodium valproate and valproic acid. Sodium valproate is sodium 2-propylpentanoate. It is also known as sodium dipropylacetic acid, sodium 2-propylvalerate, sodium dipropylacetate, ...

This work presents the development, validation and application of four simple and direct spectrophotometric methods for determination of sodium valproate (VP) through charge transfer complexation reactions. The first method is based on the reaction of the drug with p-chloranilic acid (p-CA) in a...

The reaction of disiamylborane with myrcene (7-methyl-3-methylene-1,6-octadiene) occurs selectively to place the boron atom at the 1-position. Oxidation of the resulting organoborane with alkaline hydrogen peroxide yields myrcenol (7-methyl-3-methylene-6-octen-1-ol) identified by infrared and nu...

Glutamate, the main excitatory neurotransmitter in the vertebrate Central Nervous System, is involved in almost every aspect of brain physiology, and its signaling properties are severely affected in most neurodegenerative diseases. This neurotransmitter has to be efficiently removed from the sy...

Schöllkopf's auxiliary 16 was added to bis-lactim iodide 21 to give 1,2-bis[(3S,6R)-3,6-dihydro-2,5-dimethoxy-3-isopropylpyrazin-6-yl]ethane22 in 50% d.e. Dimer 22 was separated from its diastereoisomer 23 and deprotected using 6M HCl to afford homochiral (2R,5R)-2,5-diaminohexan-1,6-dioic ...

This paper deals with the kinetic study of bulk free radical polymerization of styrene initiated with the commercial bifunctional initiator 2,5-dimethyl-2,5-bis(2-ethyl hexanoyl peroxy)hexane (Lupersol 256). The polymerization kinetics is investigated by DSC measurement for temperatures between ...

An efficient approach to 1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidyl]-3-ethyl-1,3-dihydro-benzimidazol-2-one (J-113397) Figure 1, Scheme 1, the first non-peptide ORL-1 receptor antagonist described in literature, is outlined. After construction of the piperidine framework through D...

A new class of sparingly soluble NCN palladium(II) pincer complexes of the type (NˆCˆN)PdBr: [Methyl(NˆCˆN)PdBr], C26H25N4PdBr (14), [Tosyl(NˆCˆN)PdBr], C38H33N4O4S2PdBr (15), [Benzyl(NˆCˆN)PdBr], C38H33N4PdBr (16) and [Pentyl(NˆCˆN)PdBr], C34H41N4PdBr (17) [(NˆCˆN) = 5-tert-butyl-1,3-bis-(N-sub...

A new chiral synthesis of the ORL-1 antagonist 1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one (2, J-113397) was developed. J-113397 has a Ke = 0.85 nM in an ORL-1 calcium mobilization assay and is 89-, 887-, and 227-fold selective for the O...

ABSTRACTThe interindividual pharmacokinetic variability of the α4β1 integrin antagonist 4-[1-[3-Chloro-4-[N′-(2-methylphenyl)ureido]phenylacetyl]-(4S)-fluoro-(2S)-pyrrolidine-2-yl]methoxybenzoic acid (D01-4582) was observed in beagles. The involvement of albumin genetic polymorphism in this v...

A convenient, one-step method has been developed for the synthesis of N,N′-bis(4′-aminophenyl)-1,4-quinonenediimine and its derivatives from the oxidation of p-phenyl-enediamine in the presence of aniline or substituted anilines in an acidic aqueous medium. These diimine compounds can be readi...

Owing to high chemical and thermal stability, ionic character, low nucleophilicity and peculiar solubility, cobalt bis(dicarbollide) anion occupies a unique position among the metallacarboranes. Derivatives of cobalt bis(dicarbollide) find applications in different areas such as in the treatment...