A new one-pot synthesis of tetrasubstituted furans by the reaction between unsymmetrical alkynes and esters of carboxylic acids in the presence of EtAlCl2 and Cp2TiCl2 catalyst has been developed. The effect of the unsymmetrical alkyne substituent on the chemoselectivity of the reaction was studied.

Targeting PqsD is a promising novel approach to disrupt bacterial cell-to-cell-communication in Pseudomonas aeruginosa. In search of selective PqsD inhibitors, two series of benzamidobenzoic acids – one published as RNAP inhibitors and the other as PqsD inhibitors – were investigated for inhib...

A five-step synthesis of 4-chloromethyl- and 4-mesyloxymethyl-5-tosyl-1,2,3,4-tetrahydropyrimidin-2-ones has been developed. The reaction of N-[(2-benzoyloxy-1-tosyl)ethyl]urea with sodium enolates of α-tosylketones followed by cyclization–dehydration, and debenzoylation gave 4-hydroxymethyl-5...

New cyanide selective chromogenic chemosensors based on metal-phthalocyanines containing four tosylamino groups were developed. These new receptors have high sensitivity for several anions (AcO−, F−, CN−, NO2−, H2PO4− and OH−) over other anions, such as: Br−, Cl−, NO3− and HSO4−. The experiments...

A copper-mediated direct cyanation of indoles with benzyl cyanide as the cyanide anion surrogate has been achieved. The cascade reaction furnished 3-cyanoindoles under mild reaction conditions in good to excellent yields with various functional groups tolerance.

Tosyl cyanide is activated by titanium(IV) chloride to generate a tolylsulfinyl chloride equivalent, which readily stereo- and regio-specifically adds to certain alkenes to provide β-chlorosulfoxides. These chlorides rapidly hydrolyse on silica gel to provide β-hydroxysulfoxides in stereocontr...

Two separate, rapid, sensitive and selective high-performance liquid chromatographic (HPLC) assays were developed for the determination of 4-amino-5-ethyl-3-thiophenecarboxylic acid methyl ester (I) and its acid metabolite, 4-amino-5-ethyl-3-thiophenecarboxylic acid (II), in plasma and urine. Th...

A variety of amide derivatives of (5,6-dimethoxy-2,3-dihydro-1H-inden-1-yl)acetic acid were synthesized and screened for their analgesic and anti-inflammatory activities. The compounds were found to have longer activity profile exceeding that of indomethacin in carrageenan-induced rat paw edema ...

This paper describes the method development and validation for detection of the chemical warfare agents HN-1 and HN-3 in air using C8 solid-phase extraction disks followed by liquid desorption and analysis by gas chromatography. The method is contrasted to the standard approach which uses solid ...

In this paper, the ability of Pseudomonas monteilii to selectively oxidize aryl sulfides has been investigated. Especially, a toluene-degrading strain, P. monteilii (CCTCC M2013683), was isolated form soil samples that exhibit excellent activity, stereoselectivity and high substrate tolerance to...

ObjectivesThe aim is to demonstrate significant polymerization shrinkage stress reduction in model resins through incorporation of addition–fragmentation chain transfer moieties that promote network stress accommodation by molecular rearrangement. Monomers containing allyl sulfide linkages are ...

A systematic study of the solid-liquid equilibria of the H2O-Co(NO3)2-Ni(NO3)2 ternary system enabled to define the liquidus and the solidus curves of the isotherms at 287.15 K and 313.5 K. Two widespread solid solutions, Co(1-σ)Niσ(NO3)2.6H2O and Ni(1-ω)Coω(NO3)2.6H2O, were observed. They w...

The aim of this contribution was to evaluate whether the sensitivity of the earthworm avoidance test is comparable to that of the earthworm reproduction test (standard test guidelines for both are available). The objective was to determine if relatively simple short-term tests are useful as an i...

A model is presented describing the factors and processes which determine the measured 14C ages of soil calcium carbonate. Pedogenic carbonate forms in isotopic equilium with soil CO2. Carbon dioxide in soils is a mixture of CO2 derived from two biological sources: respiration by living plant ro...

Radiocarbon dating based on geomorphological, archaeological and biological data is widely used in geomorphological studies to reconstruct sequences of climatic variations and coastal evolution during the Holocene. The coastal area of Southern Italy is characterized by aeolian dune belts shaped ...

In calcareous parent material, pedogenic carbonate formation mostly involves dissolution and recrystallization of lithogenic carbonates with CO2 of soil air, leading to a complete exchange of lithogenic carbon with soil-derived carbon. Interest in pedogenic carbonates has increased in recent dec...

This paper describes a technique for measuring the 14C content of carbonate samples by producing C− ions directly in the negative ion sputter source of an accelerator mass spectrometer (AMS) system. This direct analysis of carbonate material eliminates the time and expense of graphite preparatio...

Isotopic compositions of lacustrine carbonates are commonly used for dating and paleoenvironmental reconstructions. Here we use carbonate δ13C and δ18O, clumped (Δ47), and 14C compositions to better understand the carbonate isotope system in closed-basin lakes and trace the paleohydrologic an...

Both N- and T-type calcium ion channels have been implicated in pain transmission and the N-type channel is a well-validated target for the treatment of neuropathic pain. An SAR investigation of a series of substituted aminobenzothiazoles identified a subset of five compounds with comparable act...

Lithospermum (Boraginaceae) belongs to a small group of plant taxa that accumulate biogenic carbonate in their fruits. In this genus, carbonate incrustations form in the cells of the epidermis and sclerenchyma of the pericarp. Fossil Lithospermum fruits (nutlets) with well-preserved calcified ti...