In this study, active cobalt-based catalysts are reported for the solvent-free aerobic epoxidation of 1-decene as a non-noble metal, alternative to the conventionally used gold catalyst. No sacrificial reductant is applied and air is used as primary oxidant at ambient pressure. The influence of ...

Ionic liquids and deep eutectic solvents have aroused interest as alternative solvents for separation processes due to their favourable properties. For instance, deep eutectic solvents are usually biodegradable, non-toxic, low cost and also share some properties with ionic liquids, such as their...

CuFe2O4 samples have been successfully prepared by hydrothermal/solvothermal method under various solvents. The structural, morphological, optical and infrared radiation properties have been systemically investigated by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission el...

During the past decade, ionic liquids (ILs) have attracted increasing attention as efficient, novel solvents for dissolving cellulose. In this study, 1-butyl-3-methylimdazolium methylphosphonate ([C4C1im][(OMe)(H)PO2]) was used in the dissolution of cotton cellulose and the role of 1-methylimida...

SummaryTen cardiovascular drugs, having diverse pharmacological action, were screened for possible antimicrobial property against known eight sensitive bacteria, belonging to Gram positive and Gram negative types. Although five drugs failed to show antimicrobial activity and three had moderate a...

An accurate, simple, reproducible and sensitive HPLC method for the determination of ceterizine hydrochloride (CTZH) and paracetamol (PARA) has been developed and validated. The separation of CTZH, PARA and Nimesulide (the internal standard) was achieved on a CLC C18 (5 μ, 25cm×4.6 mm i.d) col...

The fate of 10-(1-methyl-3-pyrrolidyl methyl) phenothiazine hydrochloride (methdilazine) in the organism was studied in mice, rats, and guinea pigs. It was absorbed rather slowly from the stomach and very rapidly from the small intestine. Approximately one-fourth of an oral or subcutaneous dose ...

Four simple, selective, accurate and reproducible procedures are described for the assay of methdilazine in bulk form and in formulations. One titrimetric and three spectrophotometric methods are based on the oxidation of the drug with potassium iodate, and determination of either excess iodate ...

According to previous studies reporting the anesthetic/analgesic action of oral topical doxepin administration, this study evaluated a model of buccal permeation to determine the depth of delivery of doxepin into excised porcine buccal mucosa following topical application of a saturated aqueous ...

Histamine is an excitatory neurotransmitter in central nervous system. It plays an important role in the regulation of the sleep-wake cycle. Antidepressant with sleep-promoting effects, for example, doxepin, promotes sleep not through a sedative action but through resynchronisation of circadian ...

A high-performance liquid chromatographic method for the determination of (Z)- and (E)-doxepin hydrochloride isomers was developed. The analysis employs a column packed with spherical silica microparticles (5-6 μm), and a mobile phase of acetonitrile-chloro-form-diethylamine (750:250:0.2) permi...

Two simple, precise, and accurate extractive spectrophotometric methods have been developed for the determination of doxepin hydrochloride in pharmaceutical preparations. The methods are based on the formation of ion association complexes of doxepin with titanium (IV) and iron (III) thiocyanate ...

A selective, sensitive and rugged liquid chromatography–tandem mass spectrometry (LC–MS/MS) assay has been developed for the simultaneous determination of doxepin (Dox) and its pharmacologically active metabolite, nordoxepin (NDox) in human plasma. The analytes and their internal standards (IS...

Charge transfer complexes of the doxepin with π – acceptors such as 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ), tetracyanoquinodimethane (TCNQ) and p-chloranilic acid (p-CA) have been studied spectrophotometrically. The stoichiometry of the reactions was studied by Job's method of co...

The binding of doxepin hydrochloride (DH) to bovine serum albumin (BSA) was investigated by spectroscopic (fluorescence, UV–vis absorption and circular dichroism) techniques. The binding parameters have been evaluated by fluorescence quenching method. The thermodynamic parameters, ΔH°, ΔS° ...

A simple and sensitive spectrofluorimetric method has been developed for the determination of doxepin hydrochloride in pharmaceutical preparations. It is based on the formation of ion-pair complex between doxepin and alizarin red S at pH 3.09. The ion pair complex was extracted in dichloromethan...

New estrogen receptor α (ERα) antagonists – 3,20-dihydroxy-19-norpregna-1,3,5(10)-trienes containing an additional carbocyclic ring D′ at the 16α,17α positions – were synthesized. The effects of the new compounds on the MCF-7 breast cancer cells and ERα activation were investigated. All ...

BackgroundPlasmodium falciparum Dihydrofolate reductase (Pf-DHFR) is an essential enzyme in the folate pathway and is an important target for antimalarial drug discovery. In this study a modern approach has been undertaken to identify new hits of thiazole-1,3,5-triazine derivatives as antimalari...

Amino groups have been introduced into the phenylene rings comprising poly (phenylene ether sulphone) (PES) chains by performing nitration/reduction procedures on preformed PES and by using an aminated dichloride as a comonomer to achieve direct synthesis of aminated PES by polycondensation. It ...

Novel pyrazoles and isoxazoles were synthesized from the reaction of the carbanions of 1-aryl-2-(phenylsulphonyl)-ethanone with different hydrazonyl halides and 1-aryl-2-bromo-2-hydroximinoethanone in ethanol, respectively. Reactions were carried out under silent and ultrasonic conditions. In ge...