ATP functions as an energy source in all living things and it also plays key roles in a variety of important biological processes. Moreover, low levels of ATP are indicators of cardiovascular disease, Parkinson’s disease and ischemia. As a result, the development of fluorescent probes that dete...

1,2-bis-(N’-benzoylthioureido)cyclohexane (BTCH), C22H24N4O2S2, was successfully synthesized, characterized by infrared and NMR spectroscopic techniques and supported by X-ray structural studies. The compound was tested for the fabrication of a potentiometric sensor for Hg2+ metal ions. The sen...

A three series of thioureas, monothiourea type I (4a–g), 1,4-bisthiourea type II (5a–h) and 1,3-bisthiourea type III (6a–h) were synthesized. Their aromatase inhibitory activities have been evaluated. Interestingly, eight thiourea derivatives (4e, 5f–h, 6d, 6f–h) exhibited the aromatase inh...

Two PVC membrane ion selective electrodes for Pb(II) ion based on two bis-thioureas: 1,3-bis(N′-benzoylthioureido)benzene and 1,3-bis(N′-furoylthioureido)benzene as ionophores, are reported. A first membrane formulated using 1,3-bis(N′-benzoylthioureido)benzene as carrier exhibited a Nernstia...

Treatment of 3-phenyl-1,3-thiazolidin-4-one derivative 1 with phenylisothiocyanate in DMF, in the presence of potassium hydroxide, at room temperature gave the non-isolable potassium salt 2. The in-situ reaction of 2 with differently substituted N-aryl hydrazonoyl chlorides 3, 7a–d and 14a–d a...

The cyclization of 1,3-bis(trimethylsilyloxy)-1,3-butadienes with 3-oxo-bis(methylthio)ketenacetals afforded 3-(methylthio)phenols containing an acyl or ester substituent located at position 2. The cyclization of free 1,3-dicarbonyl dianions with 3-oxo-bis(methylthio)ketenacetals resulted in the...

Sonogashira cross-coupling of 2-chloro-3-iodopyridines with buta-1,3-diynes gave products of only iodine substitution; in the case of 2-bromo-3-iodopyridine either 2-bromo-3-(buta-1,3-diynyl)- or 2,3-bis(buta-1,3-diynyl)pyridines were obtained depending on the reaction conditions.

The synthesis and characterization of a series dipalladium(I) complexes of formulae [Pd{1-[2′-(methoxycarbonyl)phenyl]-3-[4′-X-phenyl]triazenide}]2 [X = F (4), Cl (5), Br (6)] are reported. The crystal structure of complex 4 was determined by X-ray diffraction studies. The previously reported ...

Phthalate diesters (phthalates), esters of p-hydroxybenzoic acid (parabens), and bisphenol A diglycidyl ether (BADGE) are used in personal care products, food packages, household products, or pharmaceuticals. These compounds possess endocrine-disrupting potentials and have been reported to occur...

In this research article, a highly simplified approach for the synthesis of nickel palladium bimetallic nanoparticles (Ni-PdNPs) is discussed. The synthesis method is of high novelty as it excludes involvement of any hazardous chemical and complicated laboratory set up. It is well known that gen...

A fast double-flow microfluidic based liquid phase microextraction (DF-µLPME) combined with a HPLC-UV procedure using diode array detection has been developed for the determination of the four most widely used parabens: Ethyl 4-hydroxybenzoate (EtP), Propyl 4-hydroxybenzoate (PrP), Butyl 4-hydr...

The occurrence and distribution of 13 target compounds, including eight parabens, four chlorinated parabens and p-hydroxybenzoic acid (PHBA), were detected in surface water samples at 35 sampling sites in the Beijing River system, China. The surface water samples were collected from the main riv...

An efficient method for the determination of eight parabens in human breast tumor (n = 102) and peripheral adipose tissue samples (n = 87) was successfully developed. After a precipitation procedure (acetonitrile-water-15% (w/v) zinc sulfate solution) was applied to finely-chopped tissue samples...

Crystal structures exist for human, but not rodent, estrogen receptor-α ligand-binding domain (ERα-LBD). Consequently, rodent studies involving binding of compounds to ERα-LBD are limited in their molecular-level interpretation and extrapolation to humans. Because the sequences of rodent and ...

A novel supramolecular solvent (SUPRAS) based on hexafluoroisopropanol (HFIP)/Brij-35 was proposed for liquid-phase microextraction (LPME) of parabens in water samples, pharmaceuticals and personal care products. Brij-35 is a cost-effective and non-toxic non-ionic surfactant, but it has a high c...

BackgroundBiobank serum samples from longitudinal mother-child cohorts have been used to estimate prenatal exposures to endocrine disrupting chemicals (EDCs). However, the knowledge about variations in serum concentrations of non-persistent chemicals during pregnancy is limited.

This work describes a new, fast and sensitive method for the simultaneous determination of seven paraben residues including methyl paraben (MPB), ethyl paraben (EPB), propyl paraben (PPB), isopropyl paraben (iPPB), butyl paraben (BPB), isobutyl paraben (iBPB) and benzyl paraben (BzPB) in human w...

The syntheses are reported for the first time of α-l-IdopA2SO3-(1→3)-β-d-GalpNAc4SO3-(1→4)-α-l-IdopA2SO3-(1→OMe), its disulfated analogue α-l-IdopA2SO3-(1→3)-β-d-GalpNAc-(1→4)-α-l-IdopA2SO3-(1→OMe), and of β-d-GalpNAc4SO3-(1→4)-α-l-IdopA2SO3-(1→3)-β-d-GalpNAc4SO3-(1→OMe), which...

Chondroitin O-methyl ester was depolymerized by chondroitin AC lyase (EC 4.2.2.5) from Flavobacterium heparinum. The major product isolated from the depolymerization reaction was found to be methyl α-l-threo-hex-4-enopyranosyluronate-(1→4)-2-acetamido-2-deoxy-α,β-d-galactopyranoside.

A methyl ester of hyaluronan in which the carboxyl groups were fully esterified was prepared using trimethylsilyl diazomethane. This derivative, while not depolymerized by hyaluronan lyases or hyaluronan hydrolases, was a substrate for both chondroitin ACI lyase (EC 4.2.2.5) from Flavobacterium ...