A series of bifunctional ligands of the type N,N′-{1, n}-alkanediyl-bis(pyridinyl-2-methanimine) {n = 5, 8, 9, 10, 12}(L1–L5) were synthesized and fully characterized by IR, 1H NMR, and 13C NMR spectroscopy. Binuclear palladium-methylchloride complexes C1–C5 were formed by reacting the ligand...

Structure and thermolysis of NiC2O4·2H2O (I) and Ni(HCO2)2·2H2O (II) were studied for the precipitated powders from the water solutions of precursors. The compound (I) has a disordered structure (C2/c, a=11.7916(5), b= 5.31798(14), c= 9.7806(7) Å, β = 127.014(6)°, V= 489.73(4)Å3) which is de...

An efficient protocol for the preparation of S-(1-chloro-2,2,2-trifluoroethyl)-O-ethyl xanthate is reported. This reagent serves as a versatile precursor of highly functionalized gem-difluoroalkenes through various inter- and intramolecular radical reactions and subsequent reduction with activat...

The reactions of hydroxylamine with 2-amino- and 2-methylamino-2-trifluoromethyl-5,5-dimethyltetrahydro-4-pyrones yield 2-amino- and 2-methylamino-2-trifluoromethyl-5,5-dimethyltetrahydro-4-pyrone oximes, which can be converted to 5-amino- and 5-methylamino-5-trifluoromethyl-3-(2-hydroxy-1,1-dim...

A facile two-step procedure for the synthesis of 6-(trifluoromethyl)-1,4,5,6-tetrahydropyrazolo[3,4-b]pyran derivatives (4) from the reaction of 4-arylidene-3-methyl-1-phenyl-5-pyrazolones (1) with ethyl trifluoroacetoacetate (2), a versatile fluorinated building-block, was presented. Furthermor...

Some thermodynamic and physicochemical properties of N-alkyl-pyridinium bis((trifluoromethyl)sulfonyl)imide ([CnPY][NTF2], n = 4, 6, 8) ionic liquids (ILs) were investigated through inverse gas chromatography at temperatures from 333.15 K to 373.15 K. A total of 23 solvents were used to compute ...

Densities (ρ), speeds of sound (u) and refractive index (nD) for the binary mixture of 1-Butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide [Bmim] [NTf2] with N-Vinyl-2-pyrrolidinone (NVP) over the entire range of composition and at temperatures ranging from 298.15 K to 323.15 K at 0.1...

The iron(II), cobalt(II) and chromium(III) chlorides, [2-{(2,4,6-Me3C6H2)NCMe}-8-{N(2,4,6-Me3C6H2)}C9H8N]MCln (n = 2, M = Fe LFeCl2, Co LCoCl2; n = 3, M = Cr LCrCl3), each bearing the same N,N,N-bis(imino)trihydroquinoline chelating ligand, have been employed as precatalysts for ethylene polymer...

N-Aryl-N′,N″-di(pyridin-2-yl)- and N-aryl-N′,N″-bis(6-methylpyridin-2-yl)guanidines (1–4 and 5–7) were isolated in 75%–81% yields. Reactions of Pd(OAc)2 with guanidines 2–7 carried out separately in toluene at 60 °C for 3 h afforded 8–13 respectively in 69%–80% yields. Compounds 1–13...

Dimeric alkylammonium salts – gemini surfactants – due to their unusual very low critical micelle concentration and minimal inhibitory concentration are subject to intensive research as surface active and antimicrobial compounds. Thanks to the presence of two positively charged nitrogen atoms ...

The synthesis and characterization of ten new palladium(II) amine bis(phenolate) complexes is reported. Solution and single-crystal X-ray diffraction studies reveal the presence of both κ2-N,N and κ3-N,N,O binding modes in these square planar complexes. For complexes with sterically less deman...

An asymmetric intramolecular Heck reaction that involves the dynamic kinetic resolution of an atropisomer as the substrate furnished a product in high yield with high enantioselectivity. DFT calculations (Spartan'10, B3LYP/6-31G*) confirmed that the reaction proceeded via atropisomerization...

Ketotifen, a benzocycloheptathiophene, possesses asthma-prophylactic and antiallergic activities in a number of in vitro and in vivo systems: prevention of cutaneous and lung anaphylaxis in the rat and guinea pig: inhibition of dermal and bronchial antigen challenges in man; inhibition of mediat...

Synthesis of five-, six-, seven-, eight-, and nine-membered cyclic α-hydrazino acids from a common starting material ‘diethylmalonate’ with 26, 16, 34, 13.5, and 13.33% overall yields is described. Sequential allylation or homoallylation and electrophilic amination followed by cyclization gav...

Two new methods to ensure selective alkylation of the N4 of 2-piperazinecarboxylic acid to give 4-(3-phosphonopropyl)-2-piperazinecarboxylic acid (CPP, 1) are reported. CPP can be conveniently prepared using a copper chelate to selectively protect the N1 position during alkylation. A second proc...

A facile direct [3+3] approach for the conversion of α,β-unsaturated carbonyls to multi-substituted benzenes using allylic phosphonium ylide reagents has been developed. The substituents and their positions on the benzene ring are controllable and predictable by the choice of an appropriate co...

A rapid, sensitive and simple method was developed for the quantitation of the plasma concentration of N4-[2,6-dimethoxy-4-methyl-5-[(3-trifluoromethyl)phenoxy] -8-quinolinyl]-1,4-pentanediamine, a new antimalarial active against Plasmodium vivax. N4-(5-Hexoxy-6-methoxy-4-methyl-8-quinolinyl)-1,...

Soluble fluoro-polyimides have been synthesized by reacting of a fluorine-containing aromatic diamine, 1,3-bis(4-amino-2-trifluoromethylphenoxy) benzene(diamine 3), with aromatic dianhydrides to yield poly(amic acid)s which were then cyclized to yield polyimide by either thermal or chemical imid...

The most selective β1-adrenoceptor ligand known at this moment is (S)-1-[2-((carbamoyl-4-hydroxy) phenoxy)ethylamino]-3-[4-(1-methyl-4-trifluoromethyl-2-imidazolyl)phenoxy]-2-propanol (CGP 26505), the S-isomer of CGP 20712A. We prepared the racemic 11C analogue by methylation with [11C]CH3I of ...

Polymers with bulky substituents are of pronounced interest in membrane based separation applications. In this direction, the present work reports the synthesis and characterization of a series pendant di-tert-butyl and trifluorometyl groups containing new poly(ether imide)s (PEIs). The PEIs wer...