Reaction of 2,3-dihydrofuran with aryl triflate (1) in the presence of a base and a palladium catalyst, generated in situ from Pd(OAc)2 and (R)-BINAP, gave (R)-2-aryl-2,3-dihydrofuran (2) and a small amount of (S)-2-aryl-2,5-dihydrofuran (3). The enantiomeric purity of major product 2 was strong...

The structures and energetics of the dimethylamino substituted cobaltdicarbaboranes (Me2N)2C2Bn–3Hn–3CoCp (n = 8–12) have been investigated by density functional theory. The lowest energy structures are based on the most spherical closo deltahedra in accord with the Wade-Mingos rules. Among t...

α-Phenylated 1,8-bis(dimethylamino)-2-naphthylmethyl carbocations have been shown to rearrange into 4-R-1,1,3-trimethyl-2,3-dihydroperimidinium cations through an intramolecular hydride shift from the 1-NMe2 group.

PurposeThis phase 1b study evaluated oprozomib, an oral proteasome inhibitor, plus pomalidomide-dexamethasone in relapsed/refractory multiple myeloma (RRMM).

Eight novel 2-(2,6-dioxopiperidin-3-yl)phthalimidine EM-12 dithiocarbamates 9 and 10, N-substituted 3-(phthalimidin-2-yl)-2,6-dioxopiperidines 11–14 and 3-substituted 2,6-dioxopiperidines 16and 18were synthesized as tumor necrosis factor-α (TNF-α) synthesis inhibitors. Synthesis involved util...

A series of phenolphthalein-based poly(arylene ether sulfone nitrile)s containing imidazolium groups on the side chains was synthesized to prepare anion exchange membranes (AEMs) for alkaline fuel cells. Strong polar nitrile groups were introduced into the polymer backbone with the intention of ...

A new polyphenylenevinylene (PPV) with alkoxy and sulfone substitutions on every phenylene unit has been synthesized and characterized. This polymer completes a series of sulfone (SF) containing PPVs (SF-PPVs) that are characterized by an increasing content of sulfone-substituted phenylene and a...

In order to enhance the properties of polymer anion-exchange membranes (AEMs), a class of side-chain-type poly (arylene ether sulfone)s containing tri-imidazole cations in pendant phenoxyphenyl spacer (i.e., Im-PES-xx) were designed and prepared by polymer grafting reaction. Based on these imida...

Herein we describe the preparation of novel chiral bisoxazoline ligands with various substituents at the bisoxazoline linkage, for use in the catalytic asymmetric intramolecular cyclopropanation (CAIMCP) of α-diazo-β-keto phenyl-5-hexenyl sulfone to afford a simple, but useful, bicyclo[3.1.0]h...

A series of side-chain type poly(arylene ether sulfone)s (sPAE) bearing pendant 3,5-dimethylphenyl groups are prepared via high temperature polycondensation reaction of 4,4’-biphenol, 4,4'-difluorodiphenyl sulfone, and new difluoro aromatic ketone monomer, (2,6-difluorophenyl) [3-[(3,5-dim...

(R)-5-Methylmellein (5-MM), the major ingredient in the fermented mycelia of the medicinal fungus Xylaria nigripes (called Wuling Shen in Chinese)¸ was found to be a selective inhibitor against monoamine oxidase A (MAO-A) and might play an important role in the clinical usage of this edible fung...

A novel synthesis of the human leukocyte common antigen-related (LAR) phosphatase inhibitor, illudalic acid, has been achieved by a route more amenable to structure modifications. A series of simpler analogues of illudalic acid was synthesized and evaluated for potency in inhibiting LAR. The str...

Cothermolytic reactions of trichlorosilane with chlorobenzene and 1,3-butadiene as well as partial thermolysis of HSiCl3 were studied to estimate the importance of SiCl2, compared to SiCl3, in such reactions. It is shown that SiCl2, may be formed at a temperature of 670°C via recombination of S...

The bakers' yeast reduction of (trifluoroacetyl)biphenyl derivatives produces (R)-trifluoromethyl biphenylyl carbinols in high enantioselectivity, whereas the reduction of the same derivatives with Geotrichum candidum acetone powder gives the corresponding (S)-carbinols in excellent yields ...

An efficient synthesis of new type fluorescent amino acids is described. The Fmoc-protected dyes can be prepared in a four-step procedure with ∼30% overall yield from aminofluoresceins and other inexpensive commercially available precursors. The dyes are much more photostable compared to fluore...

In this paper, we describe the design and synthesis of a novel hybrid foldamer, derived from a conformationally constrained aliphatic–aromatic amino acid conjugate that adopts a well-defined, compact, three-dimensional structure, governed by a combined conformational restriction imposed by the ...

Vascular endothelial growth factor (VEGF) stimulates endothelial cells to migrate, proliferate and form new blood vessels. However direct delivery of VEGF has not become clinically adopted as a means of stimulating blood vessel formation and wound healing because of its relatively poor stability...

The standard (po= 0.1 MPa) enthalpies of formation ΔfHmo(cr) at the temperatureT= 298.15 K were determined using static-bomb calorimetry for crystalline 5-methoxybenzofurazan (5MeOBFN), 5-methoxybenzofurazan-1-oxide (5MeOBFNO), 5-methylbenzofurazan-1-oxide (5MeBFNO), and 4-nitrobenzofurazan-1-o...

Dithiocarbaminoacetic acid (TCA) forms very stable, water soluble complexes with a number of metal ions and is a suitable masking agent in complexometry. TCA masks from EDTA and complexometric indicators at pH 2–6 the following elements: bismuth(III), indium(III), thallium(III), cadmium(II), le...

The aldohexose gulose was identified as a constituent of a hydroxyproline-rich glycopeptide derived from the glycoprotein SSG 185. This glycoprotein is part of the extracellular matrix of the green alga Volvox carteri. The gulose residue occupies a terminal position in the corresponding saccharide.