The molybdenum(VI) and tungsten(VI) complexes [MO2(L)] (M = Mo (1), W (2), H2L = bis(2-hydroxy-3,5-di-tert-butybenzyl)morpholinylethylamine) were synthesized and the complexes were used to catalyze oxotransfer reactions, viz. sulfoxidation, epoxidation and benzoin oxidation. For comparison, the ...

Two new oxido-vanadium(V) complexes, [VO(L1)(EtO)] (1) and [VO(L2)(2-BuO)] (2) [H2L1 = 2-{(5-chloro-2-hydroxyphenyl)iminomethyl}phenol and H2L2 = 4-bromo-2-{(2-hydroxy-5-methylphenyl] iminomethyl}phenol], have been prepared by the reaction of VO(acac)2 with the ONO tridentate salicylidene Schiff...

The oxido-pincer ligand pydotH2 (2,6-bis(1-hydroxy-1-o-tolyl-ethyl-η2O,O′)pyridine) forms two different CuII containing complexes when prepared from anhydrous CuCl2. A combination of EPR spectroscopy and EXAFS allowed to structurally characterise the light-green dimer of the formula [(pydotH2)...

Optically pure (S)-ethyl 3-hydroxy 4,4,4-trifluorobutanoate was prepared using the biocatalyst Candida parapsilosis ATCC 7330 by deracemisation of the racemic alcohol ester in high optical purity (96%) and yield (65%) and by asymmetric reduction from its prochiral ketone (ee up to 84% and yield ...

The oxygen atom of oximes acts as a reactive nucleophile in the iridium-catalyzed allylic substitution of unsymmetrical substrates to give the branched oxime ethers. Among several chiral ligands evaluated, the iridium complex of pybox ligand having phenyl group catalyzed the allylic substitution...

A series of novel O-(Carboalkoxy)methyl oxime ether derivatives of 3-alkyl and 3,5-dialkyl-1-methyl-2,6-diphenylpiperidin-4-ones were synthesized and characterized through FT-IR, Mass, 1H NMR, 13C NMR, 1H1H COSY, 1H13C COSY and NOESY spectral techniques. The stereocontrolled formation of E-isome...

Starting from quinuclidinyl oxime 1 identified by preliminary screening, a series of azacycles-containing oxime derivatives was synthesized. Their mPTP blocking activities were evaluated by a JC-1 assay, measuring the change of mitochondrial membrane potential. The inhibitory activity of nine co...

AimIn a search for new cardiovascular drug candidates, a series of novel oxime ethers derived from a natural isochroman-4-one were synthesized.

Three oxime ether derivatives, (E)-3-methoxy-4-(prop-2-ynyloxy)-benzaldehyde-O-prop-2-ynyl-oxime (C14H13NO3) (2), benzophenone-O-prop-2-ynyl-oxime (C16H13NO) (3) and (E)-2-chloro-6-methylquinoline-3-carbaldehyde-O-prop-2-ynyl-oxime (C14H11ClN2O) (4), have been synthesized and their crystal struc...

The importance of the oxygen atom in the C3 ether side chain of a carbocyclic influenza neuraminidase inhibitor 3 was investigated by replacement of the C3 ether oxygen atom of 3 with either a sulfur atom (compound 4) or a carbon atom (compound 5). The regio- and stereospecific syntheses of both...

The first successful method for the introduction of nitrogenous functionality at C-3 of the shikimate nucleus has been developed and has allowed the synthesis of (−)-3(R)-amino-4(R),5(R)-dihydroxy-1-cyclohexene-1-carboxylic acid [the 3(R)-amino analogue of (−)-shikimic acid] in seven steps from ...

(−)-3(R)-Amino-4(R),5(R)-dihydroxy-1-cyclohexene-1-carboxylic acid (the 3(R)-amino analogue of (−)-shikimic acid) has been synthesised from (−)-shikimic acid in seven steps.

Liquid-liquid equilibria (LLE) phase diagrams have been determined for the systems: 2-ethoxy-benzenamine + octane, or +decane, or +dodecane, or +tetradecane and for 4-ethoxy-benzenamine + heptane, or +octane. The experimental method used is based on the observation, by mean of a laser scattering...

Treatment of urea or carbamate derived benzomorpholines with lithium diisopropylamide generates N-vinyl ureas or N-vinyl carbamates by elimination of a phenoxide anion, cleaving the benzomorpholine ring. Simultaneous formation of a carbanion α to a stabilising aryl or nitrile group allows migra...

New 1,3,4-trisubstituted pyrazole derivatives were synthesized and evaluated for their antiplasmodial activity. Compounds 4b, 4c, 7a and 7d were the most potent antiplasmodial agents against P. berghei with percent of suppression ranging from 90 to 100%. They were also screened for their in vitr...

Six series of 4-(benzo[c][1,2,5]thiadiazol-5-yl)-3(5)-(6-methylpyridin-2-yl)- pyrazoles 18a–d, 19a–d, 22a–d and 3(5)-(6-methylpyridin-2-yl)-4-(thieno[3,2,-c]- pyridin-2-yl)pyrazoles 20a–d, 21a–d, 23c, 23d have been synthesized and evaluated for their activin receptor-like kinase 5 (ALK5) an...

Two types of carboxylic acid functionalized fullerence derivatives, 4-(2-ethylhexyloxy)-[6,6]-phenyl C61-butyric acid (p-EHO-PCBA) and bis-4-(2-ethylhexyloxy)-[6,6]-phenyl C61-butyric acid (bis-p-EHO-PCBA), were synthesized and investigated as an interfacial layer for inverted polymer solar cell...

A series of phenoxybutanoic acid derivatives were synthesized and tested for their antagonistic activity on the contraction of the rat thoracic aortic ring induced by endothelin-1. Preliminary screening results showed that 6e and 6g with benzoheterocycles demonstrated significant antagonistic ac...

Ab initio and DFT calculations have been performed on a complex of 1,2,5-thiadiazole with formic acid. Fifteen local minima of the complex are found using the MP2/6-31G method. In the ten planar structures, 1,2,5-thiadiazole and formic acid connect by two non-covalent bonds, such as OH···N, C...

Three novel uracil-based morpholine nucleosides each containing three different orthogonally reactive functional groups, namely, amino, carboxy and acetylene ones, were synthesized. The obtained monomers are intended for the synthesis of labeled nucleotide, nucleic acid or peptide mimics.